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Zbtb43 zinc finger and BTB domain containing 43 [ Mus musculus (house mouse) ]

Gene ID: 71834, updated on 12-May-2024

Summary

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Official Symbol
Zbtb43provided by MGI
Official Full Name
zinc finger and BTB domain containing 43provided by MGI
Primary source
MGI:MGI:1919084
See related
Ensembl:ENSMUSG00000026788 AllianceGenome:MGI:1919084
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp297b; mKIAA0414; 1700010E06Rik
Summary
Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human ZBTB43 (zinc finger and BTB domain containing 43). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 5.6), CNS E18 (RPKM 5.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zbtb43 in Genome Data Viewer
Location:
2 B; 2 22.46 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (33340299..33358592, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (33450287..33468581, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Ral GEF with PH domain and SH3 binding motif 1 Neighboring gene angiopoietin-like 2 Neighboring gene STARR-seq mESC enhancer starr_04235 Neighboring gene STARR-seq mESC enhancer starr_04237 Neighboring gene zinc finger and BTB domain containing 34 Neighboring gene STARR-seq mESC enhancer starr_04239 Neighboring gene STARR-seq mESC enhancer starr_04240 Neighboring gene STARR-seq mESC enhancer starr_04241 Neighboring gene predicted gene 13536 Neighboring gene STARR-seq mESC enhancer starr_04242 Neighboring gene predicted gene 13530 Neighboring gene predicted gene, 33642

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Z-DNA is remodelled by ZBTB43 in prospermatogonia to safeguard the germline genome and epigenome. Meng Y, et al. Nat Cell Biol, 2022 Jul. PMID 35787683, Free PMC Article
  2. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
  3. An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Pardo M, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362542, Free PMC Article
  4. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase III general transcription initiation factor binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 43
Names
ortholog of zinc finger protein 297B ZNF297B
zinc finger protein 297B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025594.1 → NP_001020765.1  zinc finger and BTB domain-containing protein 43 isoform b

    See identical proteins and their annotated locations for NP_001020765.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 4, and 5 all encode the same isoform (b).
    Source sequence(s)
    AL929212, BC043117
    Consensus CDS
    CCDS15943.1
    UniProtKB/Swiss-Prot
    Q9DAI4
    UniProtKB/TrEMBL
    Q3UGQ6
    Related
    ENSMUSP00000028125.6, ENSMUST00000028125.12
    Conserved Domains (3) summary
    sd00017
    Location:376 → 394
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18227
    Location:8 → 128
    BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)
    pfam13465
    Location:414 → 437
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001355610.1 → NP_001342539.1  zinc finger and BTB domain-containing protein 43 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 3 both encode the same isoform (a).
    Source sequence(s)
    AL929212, DV650463
    Consensus CDS
    CCDS15942.1
    UniProtKB/TrEMBL
    G3X9N4, Q3UGQ6
    Conserved Domains (3) summary
    sd00017
    Location:413 → 431
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:60 → 160
    BTB; BTB/POZ domain
    pfam13465
    Location:451 → 474
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001355611.1 → NP_001342540.1  zinc finger and BTB domain-containing protein 43 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 4, and 5 all encode the same isoform (b).
    Source sequence(s)
    AL929212
    Consensus CDS
    CCDS15943.1
    UniProtKB/Swiss-Prot
    Q9DAI4
    UniProtKB/TrEMBL
    Q3UGQ6
    Conserved Domains (3) summary
    sd00017
    Location:376 → 394
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18227
    Location:8 → 128
    BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)
    pfam13465
    Location:414 → 437
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001355612.1 → NP_001342541.1  zinc finger and BTB domain-containing protein 43 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 4, and 5 all encode the same isoform (b).
    Source sequence(s)
    AL929212, CV676247
    Consensus CDS
    CCDS15943.1
    UniProtKB/Swiss-Prot
    Q9DAI4
    UniProtKB/TrEMBL
    Q3UGQ6
    Conserved Domains (3) summary
    sd00017
    Location:376 → 394
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18227
    Location:8 → 128
    BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)
    pfam13465
    Location:414 → 437
    zf-H2C2_2; Zinc-finger double domain

  5. NM_027947.2 → NP_082223.2  zinc finger and BTB domain-containing protein 43 isoform a

    See identical proteins and their annotated locations for NP_082223.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1 and 3 both encode the same isoform (a).
    Source sequence(s)
    AK005818, AL929212, BC043117
    Consensus CDS
    CCDS15942.1
    UniProtKB/TrEMBL
    G3X9N4, Q3UGQ6
    Related
    ENSMUSP00000108781.3, ENSMUST00000113156.2
    Conserved Domains (3) summary
    sd00017
    Location:413 → 431
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:60 → 160
    BTB; BTB/POZ domain
    pfam13465
    Location:451 → 474
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    33340299..33358592 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498349.4 → XP_006498412.1  zinc finger and BTB domain-containing protein 43 isoform X1

    See identical proteins and their annotated locations for XP_006498412.1

    UniProtKB/Swiss-Prot
    Q9DAI4
    UniProtKB/TrEMBL
    Q3UGQ6
    Conserved Domains (3) summary
    sd00017
    Location:376 → 394
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18227
    Location:8 → 128
    BTB_POZ_ZBTB43; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43)
    pfam13465
    Location:414 → 437
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DAI4.2 GenPept UniProtKB/Swiss-Prot:Q9DAI4

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