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Anks4b ankyrin repeat and sterile alpha motif domain containing 4B [ Mus musculus (house mouse) ]

Gene ID: 72074, updated on 4-Jan-2025

Summary

Official Symbol
Anks4bprovided by MGI
Official Full Name
ankyrin repeat and sterile alpha motif domain containing 4Bprovided by MGI
Primary source
MGI:MGI:1919324
See related
Ensembl:ENSMUSG00000030909 AllianceGenome:MGI:1919324
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Harp; 2010013E14Rik
Summary
Acts upstream of or within response to endoplasmic reticulum stress. Located in several cellular components, including brush border; endoplasmic reticulum membrane; and microvillus. Is expressed in alimentary system; cochlea epithelium; genitourinary system; liver; and lung epithelium. Orthologous to human ANKS4B (ankyrin repeat and sterile alpha motif domain containing 4B). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in large intestine adult (RPKM 15.4), liver adult (RPKM 8.9) and 8 other tissues See more
Orthologs
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Genomic context

See Anks4b in Genome Data Viewer
Location:
7 F2; 7 64.45 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (119773081..119782939)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (120173858..120183716)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zona pellucida glycoprotein 2 Neighboring gene RIKEN cDNA 4930505K13 gene Neighboring gene STARR-seq mESC enhancer starr_20043 Neighboring gene crystallin, mu Neighboring gene ATP-binding cassette, sub-family A member 14 Neighboring gene STARR-seq mESC enhancer starr_20044 Neighboring gene STARR-seq mESC enhancer starr_20045 Neighboring gene STARR-seq mESC enhancer starr_20046

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

General gene information

Clone Names

  • MGC144693, MGC144694

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in brush border assembly  
involved_in brush border assembly  
involved_in brush border assembly  
involved_in cell differentiation  
involved_in protein localization to microvillus  
involved_in protein localization to microvillus  
involved_in protein-containing complex assembly  
involved_in protein-containing complex assembly  
acts_upstream_of_or_within response to endoplasmic reticulum stress PubMed 
Component Evidence Code Pubs
located_in brush border PubMed 
located_in brush border  
located_in endoplasmic reticulum membrane PubMed 
located_in microvillus PubMed 
located_in microvillus  
located_in plasma membrane PubMed 

General protein information

Preferred Names
ankyrin repeat and SAM domain-containing protein 4B
Names
harmonin-interacting ankyrin repeat-containing protein
harmonin-interacting ankyrin-repeat containing

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028085.2NP_082361.2  ankyrin repeat and SAM domain-containing protein 4B

    See identical proteins and their annotated locations for NP_082361.2

    Status: VALIDATED

    Source sequence(s)
    AI956809, AK008229, BC118013, BY106969
    Consensus CDS
    CCDS21793.1
    UniProtKB/Swiss-Prot
    Q148R3, Q8K3X6, Q9D8A5
    Related
    ENSMUSP00000033201.6, ENSMUST00000033201.7
    Conserved Domains (5) summary
    cd09587
    Location:350416
    SAM_HARP; SAM domain of HARP subfamily
    smart00454
    Location:357410
    SAM; Sterile alpha motif
    cd00204
    Location:3117
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:695
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:329
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    119773081..119782939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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