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Sapcd2 suppressor APC domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 72080, updated on 12-May-2024

Summary

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Official Symbol
Sapcd2provided by MGI
Official Full Name
suppressor APC domain containing 2provided by MGI
Primary source
MGI:MGI:1919330
See related
Ensembl:ENSMUSG00000026955 AllianceGenome:MGI:1919330
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ang; 2010317E24Rik; 6030458L21Rik
Summary
Involved in establishment of mitotic spindle orientation; regulation of establishment of planar polarity; and symmetric cell division. Located in apical cortex. Is expressed in several structures, including genitourinary system; liver; lung; nervous system; and neural ectoderm. Orthologous to human SAPCD2 (suppressor APC domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 8.1), limb E14.5 (RPKM 5.4) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Sapcd2 in Genome Data Viewer
Location:
2 A3; 2 17.2 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25261974..25268225)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25372035..25378213)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 46732 Neighboring gene UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E9505 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 2 Neighboring gene neural proliferation, differentiation and control 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ang is a novel gene expressed in early neuroectoderm, but its null mutant exhibits no obvious phenotype. Murata T, et al. Gene Expr Patterns, 2004 Dec. PMID 15567712
  2. Ripply2 is essential for precise somite formation during mouse early development. Chan T, et al. FEBS Lett, 2007 Jun 12. PMID 17531978
  3. SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex. Chiu CWN, et al. Dev Cell, 2016 Jan 11. PMID 26766442
  4. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
  5. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein localization to cell cortex ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of establishment of planar polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in symmetric cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in apical cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical cortex ISO
Inferred from Sequence Orthology
more info
  
located_in apical junction complex ISO
Inferred from Sequence Orthology
more info
  
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
suppressor APC domain-containing protein 2
Names
protein Ang
protein C9orf140 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081085.2 → NP_001074554.1  suppressor APC domain-containing protein 2 isoform a

    See identical proteins and their annotated locations for NP_001074554.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK163973, AK166625, AL732557, CK331200
    Consensus CDS
    CCDS38073.1
    UniProtKB/Swiss-Prot
    Q9D818
    Related
    ENSMUSP00000028329.7, ENSMUST00000028329.13
    Conserved Domains (1) summary
    pfam11414
    Location:258 → 339
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein

  2. NM_001290407.1 → NP_001277336.1  suppressor APC domain-containing protein 2 isoform b

    See identical proteins and their annotated locations for NP_001277336.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AK008577, AK166625, AL732557, CK331200
    Consensus CDS
    CCDS70999.1
    UniProtKB/Swiss-Prot
    A2AJ17, Q3TL89, Q3TP90, Q3TQ24, Q6NS42, Q9D818
    Related
    ENSMUSP00000109932.3, ENSMUST00000114293.9
    Conserved Domains (1) summary
    pfam11414
    Location:224 → 305
    Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    25261974..25268225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498360.5 → XP_006498423.1  suppressor APC domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9D818
    Related
    ENSMUSP00000097898.3, ENSMUST00000100323.3
    Conserved Domains (1) summary
    pfam11414
    Location:224 → 305
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

RNA

  1. XR_004940736.1 RNA Sequence

  2. XR_004940737.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D818.1 GenPept UniProtKB/Swiss-Prot:Q9D818

Gene LinkOut

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