U.S. flag

An official website of the United States government

Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 72508, updated on 13-Jan-2025

Summary

Official Symbol
Rps6kb1provided by MGI
Official Full Name
ribosomal protein S6 kinase, polypeptide 1provided by MGI
Primary source
MGI:MGI:1270849
See related
Ensembl:ENSMUSG00000020516 AllianceGenome:MGI:1270849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S6K; S6K1; p70s6k; P70S6K1; p70 S6KA; p70-S6K 1; p70/85s6k; S6K-beta-1; 2610318I15Rik; p70 S6K-alpha
Summary
Enables protein serine/threonine/tyrosine kinase activity. Involved in several processes, including cellular response to type II interferon; long-chain fatty acid import into cell; and negative regulation of TORC2 signaling. Acts upstream of or within several processes, including behavioral fear response; cellular response to dexamethasone stimulus; and negative regulation of signal transduction. Located in mitochondrion. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; early conceptus; leg muscle; reproductive system; and retina nuclear layer. Orthologous to human RPS6KB1 (ribosomal protein S6 kinase B1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.0), limb E14.5 (RPKM 4.8) and 26 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Rps6kb1 in Genome Data Viewer
Location:
11 C; 11 51.82 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (86389695..86435711, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (86498869..86544885, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 185 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5258 Neighboring gene predicted gene, 26439 Neighboring gene STARR-positive B cell enhancer ABC_E5259 Neighboring gene STARR-positive B cell enhancer ABC_E3003 Neighboring gene STARR-seq mESC enhancer starr_30268 Neighboring gene ring finger protein, transmembrane 1 Neighboring gene STARR-seq mESC enhancer starr_30269 Neighboring gene STARR-seq mESC enhancer starr_30270 Neighboring gene STARR-positive B cell enhancer ABC_E3004 Neighboring gene tubulin, delta 1 Neighboring gene predicted gene 9975

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

General gene information

Clone Names

  • 4732464A07Rik

Gene Ontology Provided by MGI

Items 1 - 25 of 40
Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables ATP binding  
enables ATP binding  
enables DNA-dependent protein kinase activity  
enables PDZ domain binding  
enables PDZ domain binding  
enables Rho-dependent protein serine/threonine kinase activity  
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables identical protein binding  
enables identical protein binding  
enables peptide binding  
enables peptide binding  
enables protein binding PubMed 
enables protein kinase activity PubMed 
enables protein kinase activity PubMed 
enables protein kinase activity  
enables protein phosphatase 2A binding  
enables protein phosphatase 2A binding  
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine/tyrosine kinase activity PubMed 
enables protein serine/threonine/tyrosine kinase activity PubMed 
enables ribosomal protein S6 kinase activity  
enables ribosomal protein S6 kinase activity  
Items 1 - 25 of 40
Items 1 - 25 of 66
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle  
involved_in G1/S transition of mitotic cell cycle  
involved_in TOR signaling  
involved_in TOR signaling  
involved_in TORC1 signaling  
acts_upstream_of_or_within TORC1 signaling PubMed 
involved_in apoptotic process  
acts_upstream_of_or_within behavioral fear response PubMed 
involved_in cell migration  
acts_upstream_of_or_within cellular response to dexamethasone stimulus PubMed 
involved_in cellular response to growth factor stimulus  
involved_in cellular response to growth factor stimulus  
involved_in cellular response to insulin stimulus  
acts_upstream_of_or_within cellular response to insulin stimulus PubMed 
involved_in cellular response to nutrient  
involved_in cellular response to nutrient  
acts_upstream_of_or_within cellular response to organic cyclic compound PubMed 
involved_in cellular response to type II interferon PubMed 
involved_in chromatin remodeling  
acts_upstream_of_or_within germ cell development PubMed 
involved_in long-chain fatty acid import into cell PubMed 
involved_in long-term memory  
involved_in modulation of chemical synaptic transmission PubMed 
involved_in modulation of chemical synaptic transmission PubMed 
involved_in negative regulation of TORC2 signaling PubMed 
involved_in negative regulation of apoptotic process PubMed 
involved_in negative regulation of apoptotic process  
involved_in negative regulation of apoptotic process  
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway PubMed 
acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway PubMed 
involved_in negative regulation of insulin receptor signaling pathway  
involved_in peptidyl-serine phosphorylation PubMed 
involved_in peptidyl-serine phosphorylation  
involved_in positive regulation of TORC1 signaling  
involved_in positive regulation of TORC1 signaling  
involved_in positive regulation of mitotic cell cycle  
involved_in positive regulation of mitotic cell cycle  
involved_in positive regulation of skeletal muscle tissue growth  
involved_in positive regulation of skeletal muscle tissue growth  
involved_in positive regulation of smooth muscle cell migration  
involved_in positive regulation of smooth muscle cell migration  
involved_in positive regulation of smooth muscle cell proliferation  
involved_in positive regulation of smooth muscle cell proliferation  
involved_in positive regulation of translation  
involved_in positive regulation of translational initiation  
involved_in positive regulation of translational initiation  
acts_upstream_of_or_within protein phosphorylation PubMed 
acts_upstream_of_or_within protein phosphorylation PubMed 
involved_in regulation of D-glucose import  
involved_in regulation of D-glucose import  
involved_in response to L-leucine  
involved_in response to electrical stimulus involved in regulation of muscle adaptation  
involved_in response to ethanol  
involved_in response to glucagon  
involved_in response to glucose  
involved_in response to insulin  
involved_in response to lipopolysaccharide  
involved_in response to mechanical stimulus  
involved_in response to nutrient levels  
involved_in response to testosterone  
involved_in response to toxic substance  
involved_in response to tumor necrosis factor  
involved_in response to tumor necrosis factor  
involved_in response to xenobiotic stimulus  
involved_in skeletal muscle atrophy  
involved_in skeletal muscle contraction  
Items 1 - 25 of 66
Component Evidence Code Pubs
located_in cell surface  
located_in cell surface  
is_active_in cytoplasm  
located_in cytoplasm  
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
located_in mitochondrial outer membrane  
located_in mitochondrion PubMed 
located_in mitochondrion  
located_in neuron projection  
is_active_in nucleoplasm  
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus  
located_in perinuclear region of cytoplasm  
located_in perinuclear region of cytoplasm  
located_in postsynapse  
is_active_in postsynapse  
is_active_in synapse  

General protein information

Preferred Names
ribosomal protein S6 kinase beta-1
Names
70 kDa ribosomal protein S6 kinase 1
p70 S6 kinase alpha
p70 ribosomal S6 kinase alpha
ribosomal protein S6 kinase I
ribosomal protein S6 kinase, 70kD, polypeptide 1
NP_001107806.1
NP_001350091.1
NP_082535.1
XP_006534378.1
XP_011247577.1
XP_011247578.1
XP_036012907.1
XP_036012908.1
XP_036012909.1
XP_036012910.1
XP_036012911.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114334.2NP_001107806.1  ribosomal protein S6 kinase beta-1 isoform 1

    See identical proteins and their annotated locations for NP_001107806.1

    Status: VALIDATED

    Source sequence(s)
    AK032724, AK135716, AL604063
    Consensus CDS
    CCDS48875.1
    UniProtKB/Swiss-Prot
    Q5SWG1, Q8BSK8, Q8CHX0
    UniProtKB/TrEMBL
    Q3UXD8
    Related
    ENSMUSP00000119715.2, ENSMUST00000154617.8
    Conserved Domains (1) summary
    cd05584
    Location:94416
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
  2. NM_001363162.1NP_001350091.1  ribosomal protein S6 kinase beta-1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL604063
    UniProtKB/TrEMBL
    Q3UXD8
    Conserved Domains (1) summary
    cd05584
    Location:41363
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
  3. NM_028259.4NP_082535.1  ribosomal protein S6 kinase beta-1 isoform 2

    See identical proteins and their annotated locations for NP_082535.1

    Status: VALIDATED

    Source sequence(s)
    AL604063
    Consensus CDS
    CCDS25201.1
    UniProtKB/TrEMBL
    Q8C3J7
    Related
    ENSMUSP00000053188.3, ENSMUST00000058286.9
    Conserved Domains (1) summary
    cl21453
    Location:94195
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    86389695..86435711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157018.1XP_036012911.1  ribosomal protein S6 kinase beta-1 isoform X5

    Conserved Domains (1) summary
    cl21453
    Location:1157
    PKc_like; Protein Kinases, catalytic domain
  2. XM_036157014.1XP_036012907.1  ribosomal protein S6 kinase beta-1 isoform X4

    UniProtKB/TrEMBL
    Q9CST0
    Conserved Domains (1) summary
    cl21453
    Location:1213
    PKc_like; Protein Kinases, catalytic domain
  3. XM_036157016.1XP_036012909.1  ribosomal protein S6 kinase beta-1 isoform X4

    UniProtKB/TrEMBL
    Q9CST0
    Conserved Domains (1) summary
    cl21453
    Location:1213
    PKc_like; Protein Kinases, catalytic domain
  4. XM_036157017.1XP_036012910.1  ribosomal protein S6 kinase beta-1 isoform X4

    UniProtKB/TrEMBL
    Q9CST0
    Conserved Domains (1) summary
    cl21453
    Location:1213
    PKc_like; Protein Kinases, catalytic domain
  5. XM_036157015.1XP_036012908.1  ribosomal protein S6 kinase beta-1 isoform X4

    UniProtKB/TrEMBL
    Q9CST0
    Conserved Domains (1) summary
    cl21453
    Location:1213
    PKc_like; Protein Kinases, catalytic domain
  6. XM_011249275.4XP_011247577.1  ribosomal protein S6 kinase beta-1 isoform X1

    UniProtKB/TrEMBL
    Q3UXD8
    Conserved Domains (1) summary
    cd05584
    Location:94416
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
  7. XM_006534315.5XP_006534378.1  ribosomal protein S6 kinase beta-1 isoform X2

    UniProtKB/TrEMBL
    Q3UXD8
    Conserved Domains (1) summary
    cd05584
    Location:48336
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase
  8. XM_011249276.4XP_011247578.1  ribosomal protein S6 kinase beta-1 isoform X3

    Conserved Domains (1) summary
    cd05584
    Location:94409
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

RNA

  1. XR_004937046.1 RNA Sequence

  2. XR_004937048.1 RNA Sequence

  3. XR_004937047.1 RNA Sequence

  4. XR_001780060.3 RNA Sequence

  5. XR_003949511.2 RNA Sequence

  6. XR_003949513.1 RNA Sequence

  7. XR_879743.4 RNA Sequence

  8. XR_004937043.1 RNA Sequence

  9. XR_004937042.1 RNA Sequence

  10. XR_004937044.1 RNA Sequence

  11. XR_004937045.1 RNA Sequence

External link. Please review our privacy policy.