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Ttc39c tetratricopeptide repeat domain 39C [ Mus musculus (house mouse) ]

Gene ID: 72747, updated on 5-Mar-2024

Summary

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Official Symbol
Ttc39cprovided by MGI
Official Full Name
tetratricopeptide repeat domain 39Cprovided by MGI
Primary source
MGI:MGI:1919997
See related
Ensembl:ENSMUSG00000024424 AllianceGenome:MGI:1919997
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700008N02Rik; 2810439F02Rik
Summary
Predicted to be involved in cilium assembly and otolith morphogenesis. Is expressed in adrenal medulla; clavicle; naris; nervous system; and seminiferous cord. Orthologous to human TTC39C (tetratricopeptide repeat domain 39C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 14.3), testis adult (RPKM 14.1) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 A1; 18 6.71 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (12716168..12872461)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (12583103..12739404)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene laminin, alpha 3 Neighboring gene STARR-positive B cell enhancer ABC_E8704 Neighboring gene predicted gene, 36232 Neighboring gene STARR-seq mESC enhancer starr_43837 Neighboring gene predicted gene 29200 Neighboring gene STARR-seq mESC enhancer starr_43839 Neighboring gene STARR-seq mESC enhancer starr_43841 Neighboring gene STARR-seq mESC enhancer starr_43842 Neighboring gene predicted gene, 41668 Neighboring gene microRNA 1948 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene oxysterol binding protein-like 1A Neighboring gene calcium binding tyrosine phosphorylation regulated Neighboring gene predicted gene, 52343

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ttc39c is upregulated during skeletal muscle atrophy and modulates ERK1/2 MAP kinase and hedgehog signaling. Hayes CS, et al. J Cell Physiol, 2019 Dec. PMID 31188487
  2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in otolith morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
tetratricopeptide repeat protein 39C
Names
TPR repeat protein 39C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028341.5 → NP_082617.2  tetratricopeptide repeat protein 39C

    See identical proteins and their annotated locations for NP_082617.2

    Status: VALIDATED

    Source sequence(s)
    AC102055, AC139027
    Consensus CDS
    CCDS29065.1
    UniProtKB/Swiss-Prot
    Q8VE09, Q9CYV6
    UniProtKB/TrEMBL
    A0A3Q4EGC9
    Related
    ENSMUSP00000157144.2, ENSMUST00000234966.2
    Conserved Domains (1) summary
    pfam10300
    Location:31 → 495
    DUF3808; Protein of unknown function (DUF3808)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    12716168..12872461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250614.2 → XP_030106474.1  tetratricopeptide repeat protein 39C isoform X1

    UniProtKB/Swiss-Prot
    Q8VE09, Q9CYV6
    UniProtKB/TrEMBL
    E9PV21, G3X8X1
    Related
    ENSMUSP00000133127.2, ENSMUST00000169401.8
    Conserved Domains (1) summary
    pfam10300
    Location:1 → 437
    DUF3808; Protein of unknown function (DUF3808)

  2. XM_030250615.2 → XP_030106475.1  tetratricopeptide repeat protein 39C isoform X2

    Conserved Domains (1) summary
    pfam10300
    Location:1 → 181
    DUF3808; Protein of unknown function (DUF3808)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VE09.2 GenPept UniProtKB/Swiss-Prot:Q8VE09

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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