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Tmed5 transmembrane p24 trafficking protein 5 [ Mus musculus (house mouse) ]

Gene ID: 73130, updated on 11-Apr-2024

Summary

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Official Symbol
Tmed5provided by MGI
Official Full Name
transmembrane p24 trafficking protein 5provided by MGI
Primary source
MGI:MGI:1921586
See related
Ensembl:ENSMUSG00000063406 AllianceGenome:MGI:1921586
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p24gamma2; 3110020O18Rik; 4432412D15Rik
Summary
Predicted to be involved in Golgi ribbon formation; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to act upstream of or within protein transport. Predicted to be located in cis-Golgi network and endoplasmic reticulum exit site. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human TMED5 (transmembrane p24 trafficking protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 9.7), placenta adult (RPKM 7.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 52.49 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108269422..108280486, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108121556..108132620, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13900 Neighboring gene ribosomal protein S19, pseudogene 8 Neighboring gene STARR-seq mESC enhancer starr_13901 Neighboring gene STARR-seq mESC enhancer starr_13902 Neighboring gene metal response element binding transcription factor 2 Neighboring gene STARR-seq mESC enhancer starr_13904 Neighboring gene STARR-positive B cell enhancer ABC_E2166 Neighboring gene coiled-coil domain containing 18 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 8190

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Crystallographic analysis of murine p24γ2 Golgi dynamics domain. Nagae M, et al. Proteins, 2017 Apr. PMID 28066915
  2. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crystallographic analysis of murine p24gamma2 Golgi dynamics domain has been reported.
    Title: Crystallographic analysis of murine p24γ2 Golgi dynamics domain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cargo receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in Golgi ribbon formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi ribbon formation ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cis-Golgi network ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum exit site ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane emp24 domain-containing protein 5
Names
p24 family protein gamma-2
transmembrane emp24 protein transport domain containing 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347383.2 → NP_001334312.1  transmembrane emp24 domain-containing protein 5 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC159996
    Consensus CDS
    CCDS84924.1
    UniProtKB/TrEMBL
    D3Z615, Q3V440
    Related
    ENSMUSP00000112612.2, ENSMUST00000117759.2

  2. NM_001361466.1 → NP_001348395.1  transmembrane emp24 domain-containing protein 5 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC159996
    UniProtKB/TrEMBL
    Q3U9T7
    Conserved Domains (1) summary
    pfam01105
    Location:35 → 183
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD

  3. NM_001361467.1 → NP_001348396.1  transmembrane emp24 domain-containing protein 5 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC159996
    UniProtKB/TrEMBL
    D3Z615
    Conserved Domains (1) summary
    pfam01105
    Location:35 → 96
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD

  4. NM_028876.3 → NP_083152.1  transmembrane emp24 domain-containing protein 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_083152.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC159996, AK014490, BB376243, BB764499
    Consensus CDS
    CCDS19508.1
    UniProtKB/Swiss-Prot
    Q3TDS6, Q9CXE7
    UniProtKB/TrEMBL
    A2RS96, Q3U9T7, Q8VCE7
    Related
    ENSMUSP00000002837.5, ENSMUST00000002837.11
    Conserved Domains (1) summary
    pfam01105
    Location:35 → 222
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    108269422..108280486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CXE7.1 GenPept UniProtKB/Swiss-Prot:Q9CXE7

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