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Iws1 IWS1, SUPT6 interacting protein [ Mus musculus (house mouse) ]

Gene ID: 73473, updated on 8-May-2024

Summary

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Official Symbol
Iws1provided by MGI
Official Full Name
IWS1, SUPT6 interacting proteinprovided by MGI
Primary source
MGI:MGI:1920723
See related
Ensembl:ENSMUSG00000024384 AllianceGenome:MGI:1920723
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3000008H23; 1700069O15Rik
Summary
Predicted to be involved in several processes, including poly(A)+ mRNA export from nucleus; regulation of histone modification; and regulation of mRNA export from nucleus. Predicted to act upstream of or within RNA splicing; mRNA processing; and mRNA transport. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; immune system; and nervous system. Orthologous to human IWS1 (interacts with SUPT6H, CTD assembly factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.3), whole brain E14.5 (RPKM 5.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Iws1 in Genome Data Viewer
Location:
18 B1; 18 17.92 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (32200377..32237384)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (32067326..32104331)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene myosin VIIB Neighboring gene predicted gene 16344 Neighboring gene STARR-seq mESC enhancer starr_44153 Neighboring gene predicted gene, 35010 Neighboring gene protein C Neighboring gene eukaryotic translation initiation factor pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic ablation of interacting with Spt6 (Iws1) causes early embryonic lethality. Orlacchio A, et al. PLoS One, 2018. PMID 30208029, Free PMC Article
  2. Iws1 and Spt6 Regulate Trimethylation of Histone H3 on Lysine 36 through Akt Signaling and are Essential for Mouse Embryonic Genome Activation. Oqani RK, et al. Sci Rep, 2019 Mar 7. PMID 30846735, Free PMC Article
  3. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  4. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Iws1 and Spt6 Regulate Trimethylation of Histone H3 on Lysine 36 through Akt Signaling and are Essential for Mouse Embryonic Genome Activation.
    Title: Iws1 and Spt6 Regulate Trimethylation of Histone H3 on Lysine 36 through Akt Signaling and are Essential for Mouse Embryonic Genome Activation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription elongation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein IWS1 homolog
Names
IWS1 homolog
IWS1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173441.4 → NP_775617.1  protein IWS1 homolog

    See identical proteins and their annotated locations for NP_775617.1

    Status: VALIDATED

    Source sequence(s)
    AC127347
    Consensus CDS
    CCDS29115.1
    UniProtKB/Swiss-Prot
    Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q8C1D8, Q9D9H4
    Related
    ENSMUSP00000025243.4, ENSMUST00000025243.5
    Conserved Domains (2) summary
    PHA02664
    Location:206 → 317
    PHA02664; hypothetical protein; Provisional
    cl00146
    Location:475 → 739
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    32200377..32237384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526292.5 → XP_006526355.1  protein IWS1 homolog isoform X2

    Conserved Domains (2) summary
    COG5271
    Location:3 → 464
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cl00146
    Location:474 → 738
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

  2. XM_006526291.5 → XP_006526354.1  protein IWS1 homolog isoform X1

    UniProtKB/TrEMBL
    A0A1D5RLV0
    Related
    ENSMUSP00000148514.2, ENSMUST00000212675.2
    Conserved Domains (2) summary
    COG5271
    Location:18 → 462
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    cl00146
    Location:475 → 724
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

RNA

  1. XR_386017.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C1D8.1 GenPept UniProtKB/Swiss-Prot:Q8C1D8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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