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Ankrd42 ankyrin repeat domain 42 [ Mus musculus (house mouse) ]

Gene ID: 73845, updated on 5-Mar-2024

Summary

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Official Symbol
Ankrd42provided by MGI
Official Full Name
ankyrin repeat domain 42provided by MGI
Primary source
MGI:MGI:1921095
See related
Ensembl:ENSMUSG00000041343 AllianceGenome:MGI:1921095
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ikbn; 4931426M20; 4933417L02Rik
Summary
Enables NF-kappaB binding activity. Acts upstream of or within positive regulation of NF-kappaB transcription factor activity and positive regulation of cytokine production involved in inflammatory response. Located in nucleus. Orthologous to human ANKRD42 (ankyrin repeat domain 42). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 35.0), CNS E18 (RPKM 2.4) and 2 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 E1; 7 51.52 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (92230922..92286348, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (92584183..92637142, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene discs large MAGUK scaffold protein 2 Neighboring gene predicted gene, 53382 Neighboring gene STARR-seq mESC enhancer starr_19525 Neighboring gene predicted gene, 31491 Neighboring gene STARR-positive B cell enhancer ABC_E6571 Neighboring gene STARR-positive B cell enhancer ABC_E291 Neighboring gene STARR-seq mESC enhancer starr_19528 Neighboring gene coiled-coil domain containing 90B Neighboring gene predicted gene, 26944 Neighboring gene pantothenate kinase 1 pseudogene Neighboring gene PCF11 cleavage and polyadenylation factor subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IkappaBeta, a nuclear IkappaB protein, positively regulates the NF-kappaB-mediated expression of proinflammatory cytokines. Yamauchi S, et al. Proc Natl Acad Sci U S A, 2010 Jun 29. PMID 20547855, Free PMC Article
  2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IkappaBeta regulates the NF-kappaB-mediated transcription of a wide variety of proinflammatory genes, playing a crucial role in the regulation of innate immune responses.
    Title: IkappaBeta, a nuclear IkappaB protein, positively regulates the NF-kappaB-mediated expression of proinflammatory cytokines.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NF-kappaB binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NF-kappaB binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001407912.1 → NP_001394841.1  ankyrin repeat domain-containing protein 42 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC104921, AC158144
    UniProtKB/Swiss-Prot
    Q3V096, Q8BX55, Q8BZT3, Q8C0T6, Q8C0X5
    Related
    ENSMUSP00000061208.8, ENSMUST00000056106.14

  2. NM_001407913.1 → NP_001394842.1  ankyrin repeat domain-containing protein 42 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC104921, AC158144

  3. NM_001407914.1 → NP_001394843.1  ankyrin repeat domain-containing protein 42 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC104921, AC158144

  4. NM_028665.5 → NP_082941.2  ankyrin repeat domain-containing protein 42 isoform 1

    See identical proteins and their annotated locations for NP_082941.2

    Status: VALIDATED

    Source sequence(s)
    AC104921, AC158144
    Consensus CDS
    CCDS52310.1
    UniProtKB/TrEMBL
    A0A0R4J1P5
    Related
    ENSMUSP00000113767.2, ENSMUST00000118157.8
    Conserved Domains (4) summary
    cd00204
    Location:93 → 212
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:64 → 156
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:159 → 212
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:59 → 90
    ANK; ANK repeat [structural motif]

RNA

  1. NR_176432.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104921, AC158144
    Related
    ENSMUST00000126305.8

  2. NR_176433.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC104921, AC158144

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    92230922..92286348 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508232.5 → XP_006508295.1  ankyrin repeat domain-containing protein 42 isoform X2

    Conserved Domains (4) summary
    PHA03095
    Location:17 → 288
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:59 → 90
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:64 → 156
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:269 → 318
    Ank_4; Ankyrin repeats (many copies)

  2. XM_036153478.1 → XP_036009371.1  ankyrin repeat domain-containing protein 42 isoform X3

    UniProtKB/TrEMBL
    B7ZNV8
    Related
    ENSMUSP00000147057.2, ENSMUST00000207131.2
    Conserved Domains (4) summary
    PHA03095
    Location:17 → 288
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:59 → 90
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:269 → 318
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:64 → 156
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_017312337.3 → XP_017167826.1  ankyrin repeat domain-containing protein 42 isoform X4

    Conserved Domains (4) summary
    PLN03192
    Location:133 → 193
    PLN03192; Voltage-dependent potassium channel; Provisional
    sd00045
    Location:59 → 90
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:64 → 156
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:28 → 80
    Ank_4; Ankyrin repeats (many copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V096.1 GenPept UniProtKB/Swiss-Prot:Q3V096

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