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Ttf2 transcription termination factor, RNA polymerase II [ Mus musculus (house mouse) ]

Gene ID: 74044, updated on 11-Apr-2024

Summary

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Official Symbol
Ttf2provided by MGI
Official Full Name
transcription termination factor, RNA polymerase IIprovided by MGI
Primary source
MGI:MGI:1921294
See related
Ensembl:ENSMUSG00000033222 AllianceGenome:MGI:1921294
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
8030447N19; 4632434F22Rik
Summary
Predicted to enable ATP-dependent activity, acting on DNA. Predicted to act upstream of or within DNA-templated transcription, termination; RNA splicing; and mRNA processing. Predicted to be located in cytosol. Predicted to be part of spliceosomal complex. Is expressed in olfactory cortex ventricular layer and telencephalon ventricular layer. Orthologous to human TTF2 (transcription termination factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.9), limb E14.5 (RPKM 4.1) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F2.2; 3 43.86 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (100846176..100877016, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (100938860..100969700, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E232 Neighboring gene predicted gene, 40108 Neighboring gene tripartite motif-containing 45 Neighboring gene STARR-positive B cell enhancer ABC_E2678 Neighboring gene CD101 antigen Neighboring gene STARR-seq mESC enhancer starr_08505 Neighboring gene prostaglandin F2 receptor negative regulator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cytochrome P450 2E1-dependent oxidant stress and upregulation of anti-oxidant defense in liver cells. Cederbaum AI. J Gastroenterol Hepatol, 2006 Oct. PMID 16958665
  2. Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice. Penha-Gonçalves C, et al. Diabetes, 2003 Jun. PMID 12765969
  3. Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain-dependent manner. Tiozzo C, et al. Endocr Relat Cancer, 2012 Apr. PMID 22167068, Free PMC Article
  4. An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Pardo M, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362542, Free PMC Article
  5. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent activity, acting on DNA ISO
Inferred from Sequence Orthology
more info
  
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA-templated transcription termination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription termination factor 2
Names
RNA polymerase II termination factor
transcription release factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013026.2 → NP_001013044.2  transcription termination factor 2

    See identical proteins and their annotated locations for NP_001013044.2

    Status: VALIDATED

    Source sequence(s)
    AK087352, BC087733, BC096625
    Consensus CDS
    CCDS17679.1
    UniProtKB/Swiss-Prot
    Q4V9Y7, Q5M924, Q5NC05
    Related
    ENSMUSP00000076208.6, ENSMUST00000076941.12
    Conserved Domains (5) summary
    cd00046
    Location:566 → 744
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:549 → 909
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:966 → 1082
    Helicase_C; Helicase conserved C-terminal domain
    pfam06839
    Location:4 → 44
    zf-GRF; GRF zinc finger
    pfam10243
    Location:132 → 464
    MIP-T3; Microtubule-binding protein MIP-T3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    100846176..100877016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163360.1 → XP_036019253.1  transcription termination factor 2 isoform X2

    Conserved Domains (4) summary
    PHA03169
    Location:149 → 325
    PHA03169; hypothetical protein; Provisional
    COG0553
    Location:546 → 1133
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18072
    Location:543 → 793
    DEXHc_TTF2; DEAH-box helicase domain of TTF2
    pfam06839
    Location:4 → 44
    zf-GRF; GRF zinc finger

  2. XM_036163359.1 → XP_036019252.1  transcription termination factor 2 isoform X1

    Conserved Domains (3) summary
    COG0553
    Location:566 → 1153
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18072
    Location:563 → 813
    DEXHc_TTF2; DEAH-box helicase domain of TTF2
    pfam06839
    Location:4 → 44
    zf-GRF; GRF zinc finger

  3. XM_036163361.1 → XP_036019254.1  transcription termination factor 2 isoform X3

    Conserved Domains (3) summary
    COG0553
    Location:566 → 1107
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18072
    Location:563 → 813
    DEXHc_TTF2; DEAH-box helicase domain of TTF2
    pfam06839
    Location:4 → 44
    zf-GRF; GRF zinc finger

RNA

  1. XR_375588.3 RNA Sequence

  2. XR_004941407.1 RNA Sequence

  3. XR_004941408.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5NC05.2 GenPept UniProtKB/Swiss-Prot:Q5NC05

Gene LinkOut

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