Acot12 acyl-CoA thioesterase 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acot12provided by MGI
Official Full Name: acyl-CoA thioesterase 12provided by MGI
Primary source: MGI:MGI:1921406
See related: Ensembl:ENSMUSG00000021620 AllianceGenome:MGI:1921406
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cach; CACH-1; mCACH-1; 1300004O04Rik; 4930449F15Rik
Summary: Enables ATP binding activity and acetyl-CoA hydrolase activity. Acts upstream of or within acetyl-CoA metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in alimentary system and liver. Orthologous to human ACOT12 (acyl-CoA thioesterase 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 18.2), kidney adult (RPKM 14.7) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C3; 13 47.43 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (91889635..91934271)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (91741326..91786148)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulated FOXM1 stimulates chondrocyte senescence in Acot12[-/-]Nudt7[-/-] double knockout mice.
Title: Upregulated FOXM1 stimulates chondrocyte senescence in Acot12(-/-)Nudt7(-/-) double knockout mice.
Acyl-CoA thioesterase 12 suppresses YAP-mediated hepatocarcinogenesis by limiting glycerolipid biosynthesis.
Title: Acyl-CoA thioesterase 12 suppresses YAP-mediated hepatocarcinogenesis by limiting glycerolipid biosynthesis.
Loss of Acot12 contributes to NAFLD independent of lipolysis of adipose tissue.
Title: Loss of Acot12 contributes to NAFLD independent of lipolysis of adipose tissue.
possibly involved in fat metabolism. Here it is sequenced and expressed functionally.
Title: Mouse cytosolic acetyl-CoA hydrolase, a novel candidate for a key enzyme involved in fat metabolism: cDNA cloning, sequencing and functional expression.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation

General gene information

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Markers

MT2492 (e-PCR)
- UniSTS:127012

D13Mit193.1 (e-PCR), detects polymorphism
- UniSTS:127013

AV027244 (e-PCR)
- UniSTS:165885

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables acetyl-CoA hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables thiolester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within acetyl-CoA metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in acyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid metabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acetyl-coenzyme A thioesterase

Names: acyl-CoA thioester hydrolase 12; acyl-coenzyme A thioesterase 12; cytoplasmic acetyl-CoA hydrolase 1; cytosolic acetyl-CoA hydrolase

NP_001405606.1

EC 3.1.2.1

NP_083066.1

EC 3.1.2.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418677.1 → NP_001405606.1 acetyl-coenzyme A thioesterase isoform 2

Status: VALIDATED

Source sequence(s)

AC154413
NM_028790.4 → NP_083066.1 acetyl-coenzyme A thioesterase isoform 1

See identical proteins and their annotated locations for NP_083066.1

Status: VALIDATED

Source sequence(s)

AC154413

Consensus CDS

CCDS26678.1

UniProtKB/Swiss-Prot

Q544M5, Q8R108, Q9DBK0

UniProtKB/TrEMBL

A2RSC2

Related

ENSMUSP00000022120.5, ENSMUST00000022120.5

Conserved Domains (2) summary

cd03442
Location:182 → 306

BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

cl14643
Location:312 → 547

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily