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Tgm5 transglutaminase 5 [ Mus musculus (house mouse) ]

Gene ID: 74176, updated on 30-Apr-2024

Summary

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Official Symbol
Tgm5provided by MGI
Official Full Name
transglutaminase 5provided by MGI
Primary source
MGI:MGI:1921426
See related
Ensembl:ENSMUSG00000053675 AllianceGenome:MGI:1921426
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TGx; TGMX; TGase-5; 2310007C07Rik
Summary
Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in peptide cross-linking. Predicted to be located in cytoplasm. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in peeling skin syndrome. Orthologous to human TGM5 (transglutaminase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 1.0), cerebellum adult (RPKM 0.8) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E5; 2 60.37 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120876591..120916322, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121046111..121085841, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cyclin D-type binding-protein 1 Neighboring gene erythrocyte membrane protein band 4.2 Neighboring gene STARR-seq mESC enhancer starr_05521 Neighboring gene WW domain binding protein 2 pseudogene Neighboring gene transglutaminase 7 Neighboring gene predicted gene, 23858

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Knocking-in the R142C mutation in transglutaminase 1 disrupts the stratum corneum barrier and postnatal survival of mice. Nakagawa N, et al. J Dermatol Sci, 2012 Mar. PMID 22258055
  2. Two Ancient Gene Families Are Critical for Maintenance of the Mammalian Skin Barrier in Postnatal Life. Cangkrama M, et al. J Invest Dermatol, 2016 Jul. PMID 26975724
  3. Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z. Grenard P, et al. J Biol Chem, 2001 Aug 31. PMID 11390390
  4. ZFP750 affects the cutaneous barrier through regulating lipid metabolism. Butera A, et al. Sci Adv, 2023 Apr 28. PMID 37115925, Free PMC Article
  5. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC143848, MGC143849

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-glutamine gamma-glutamyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptide cross-linking IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein-glutamine gamma-glutamyltransferase 5
NP_001349653.1
NP_083075.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362724.2 → NP_001349653.1  protein-glutamine gamma-glutamyltransferase 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL844548
    Conserved Domains (2) summary
    smart00460
    Location:57 → 134
    TGc; Transglutaminase/protease-like homologues
    pfam00927
    Location:390 → 487
    Transglut_C; Transglutaminase family, C-terminal ig like domain

  2. NM_028799.4 → NP_083075.1  protein-glutamine gamma-glutamyltransferase 5 isoform 1

    See identical proteins and their annotated locations for NP_083075.1

    Status: VALIDATED

    Source sequence(s)
    AL844548
    Consensus CDS
    CCDS16632.1
    UniProtKB/Swiss-Prot
    A2AQ62, Q3V1F9, Q9D7I9
    UniProtKB/TrEMBL
    Q14B90, Q14B91
    Related
    ENSMUSP00000028721.8, ENSMUST00000028721.8
    Conserved Domains (3) summary
    smart00460
    Location:275 → 368
    TGc; Transglutaminase/protease-like homologues
    pfam00868
    Location:11 → 126
    Transglut_N; Transglutaminase family
    pfam00927
    Location:624 → 721
    Transglut_C; Transglutaminase family, C-terminal ig like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    120876591..120916322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D7I9.3 GenPept UniProtKB/Swiss-Prot:Q9D7I9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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