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Eif4enif1 eukaryotic translation initiation factor 4E nuclear import factor 1 [ Mus musculus (house mouse) ]

Gene ID: 74203, updated on 28-Apr-2024

Summary

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Official Symbol
Eif4enif1provided by MGI
Official Full Name
eukaryotic translation initiation factor 4E nuclear import factor 1provided by MGI
Primary source
MGI:MGI:1921453
See related
Ensembl:ENSMUSG00000020454 AllianceGenome:MGI:1921453
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Clast4; D11Ertd166e; 2610509L04Rik; A930019J01Rik
Summary
Enables mRNA binding activity. Acts upstream of or within negative regulation of neuron differentiation; negative regulation of translation; and stem cell population maintenance. Located in P-body; cytosol; and nucleus. Is expressed in several structures, including cerebral cortex; early conceptus; epithelium; metanephros; and ovary. Orthologous to human EIF4ENIF1 (eukaryotic translation initiation factor 4E nuclear import factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 18.2), CNS E11.5 (RPKM 15.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A1; 11 2.24 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3152344..3194588)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3202343..3244588)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Sfi1 homolog, spindle assembly associated (yeast) Neighboring gene elongation factor 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6943 Neighboring gene Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived), pseudogene 2 Neighboring gene predicted gene, 51877 Neighboring gene developmentally regulated GTP binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_28343 Neighboring gene STARR-seq mESC enhancer starr_28345 Neighboring gene POZ (BTB) and AT hook containing zinc finger 1 Neighboring gene predicted gene 12592 Neighboring gene predicted gene 11944

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The P-body protein 4E-T represses translation to regulate the balance between cell genesis and establishment of the postnatal NSC pool. Kolaj A, et al. Cell Rep, 2023 Mar 28. PMID 36924490
  2. Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches. Martínez A, et al. PLoS One, 2015. PMID 25923732, Free PMC Article
  3. Clast4, the murine homologue of human eIF4E-Transporter, is highly expressed in developing oocytes and post-translationally modified at meiotic maturation. Villaescusa JC, et al. Gene, 2006 Feb 15. PMID 16343815
  4. Genome-wide analysis of H4K5 acetylation associated with fear memory in mice. Park CS, et al. BMC Genomics, 2013 Aug 8. PMID 23927422, Free PMC Article
  5. A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis. Amadei G, et al. J Neurosci, 2015 Nov 25. PMID 26609159, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Eif4enif1 haploinsufficiency disrupts oocyte mitochondrial dynamics and leads to subfertility.
    Title: Eif4enif1 haploinsufficiency disrupts oocyte mitochondrial dynamics and leads to subfertility.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear export signal receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in P-body assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_positive_effect miRNA-mediated gene silencing by inhibition of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of neuron differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of neuron differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in P-body ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 4E transporter
Names
4E-T
CD40 ligand-activated specific transcript 4
eIF4E transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166547.1 → NP_001160019.1  eukaryotic translation initiation factor 4E transporter isoform a

    See identical proteins and their annotated locations for NP_001160019.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AK165678, BC033410
    Consensus CDS
    CCDS24354.1
    UniProtKB/Swiss-Prot
    Q8CFW0, Q9CSS3, Q9EST3
    UniProtKB/TrEMBL
    Q8BY82
    Related
    ENSMUSP00000136768.2, ENSMUST00000179770.8
    Conserved Domains (2) summary
    pfam03154
    Location:707 → 934
    Atrophin-1; Atrophin-1 family
    pfam10477
    Location:29 → 710
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

  2. NM_001166548.1 → NP_001160020.1  eukaryotic translation initiation factor 4E transporter isoform b

    See identical proteins and their annotated locations for NP_001160020.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK041598, BC033410, CJ072393
    Consensus CDS
    CCDS48739.1
    UniProtKB/TrEMBL
    Q8BY82
    Related
    ENSMUSP00000020734.5, ENSMUST00000020734.11
    Conserved Domains (2) summary
    pfam03154
    Location:683 → 910
    Atrophin-1; Atrophin-1 family
    pfam10477
    Location:29 → 686
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

  3. NM_001166549.1 → NP_001160021.1  eukaryotic translation initiation factor 4E transporter isoform b

    See identical proteins and their annotated locations for NP_001160021.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    BC033410, BY068596
    Consensus CDS
    CCDS48739.1
    UniProtKB/TrEMBL
    Q8BY82
    Related
    ENSMUSP00000105675.2, ENSMUST00000110048.8
    Conserved Domains (2) summary
    pfam03154
    Location:683 → 910
    Atrophin-1; Atrophin-1 family
    pfam10477
    Location:29 → 686
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

  4. NM_023743.2 → NP_076232.2  eukaryotic translation initiation factor 4E transporter isoform a

    See identical proteins and their annotated locations for NP_076232.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.
    Source sequence(s)
    AL671968, BC033410
    Consensus CDS
    CCDS24354.1
    UniProtKB/Swiss-Prot
    Q8CFW0, Q9CSS3, Q9EST3
    UniProtKB/TrEMBL
    Q8BY82
    Related
    ENSMUSP00000105676.2, ENSMUST00000110049.8
    Conserved Domains (2) summary
    pfam03154
    Location:707 → 934
    Atrophin-1; Atrophin-1 family
    pfam10477
    Location:29 → 710
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    3152344..3194588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514842.5 → XP_006514905.1  eukaryotic translation initiation factor 4E transporter isoform X1

    See identical proteins and their annotated locations for XP_006514905.1

    UniProtKB/Swiss-Prot
    Q8CFW0, Q9CSS3, Q9EST3
    UniProtKB/TrEMBL
    Q8BY82
    Conserved Domains (2) summary
    pfam03154
    Location:707 → 934
    Atrophin-1; Atrophin-1 family
    pfam10477
    Location:29 → 710
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

  2. XM_006514844.4 → XP_006514907.1  eukaryotic translation initiation factor 4E transporter isoform X2

    See identical proteins and their annotated locations for XP_006514907.1

    UniProtKB/TrEMBL
    Q8BY82
    Conserved Domains (2) summary
    pfam03154
    Location:683 → 910
    Atrophin-1; Atrophin-1 family
    pfam10477
    Location:29 → 686
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

  3. XM_006514841.4 → XP_006514904.1  eukaryotic translation initiation factor 4E transporter isoform X1

    See identical proteins and their annotated locations for XP_006514904.1

    UniProtKB/Swiss-Prot
    Q8CFW0, Q9CSS3, Q9EST3
    UniProtKB/TrEMBL
    Q8BY82
    Conserved Domains (2) summary
    pfam03154
    Location:707 → 934
    Atrophin-1; Atrophin-1 family
    pfam10477
    Location:29 → 710
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

  4. XM_017314806.3 → XP_017170295.1  eukaryotic translation initiation factor 4E transporter isoform X2

    UniProtKB/TrEMBL
    Q8BY82
    Conserved Domains (2) summary
    pfam03154
    Location:683 → 910
    Atrophin-1; Atrophin-1 family
    pfam10477
    Location:29 → 686
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

  5. XM_006514843.5 → XP_006514906.1  eukaryotic translation initiation factor 4E transporter isoform X1

    See identical proteins and their annotated locations for XP_006514906.1

    UniProtKB/Swiss-Prot
    Q8CFW0, Q9CSS3, Q9EST3
    UniProtKB/TrEMBL
    Q8BY82
    Conserved Domains (2) summary
    pfam03154
    Location:707 → 934
    Atrophin-1; Atrophin-1 family
    pfam10477
    Location:29 → 710
    EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EST3.2 GenPept UniProtKB/Swiss-Prot:Q9EST3

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