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Rmi1 RecQ mediated genome instability 1 [ Mus musculus (house mouse) ]

Gene ID: 74386, updated on 9-May-2024

Summary

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Official Symbol
Rmi1provided by MGI
Official Full Name
RecQ mediated genome instability 1provided by MGI
Primary source
MGI:MGI:1921636
See related
Ensembl:ENSMUSG00000035367 AllianceGenome:MGI:1921636
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4932432N11Rik
Summary
Predicted to enable nucleotide binding activity. Acts upstream of or within glucose homeostasis; reduction of food intake in response to dietary excess; and response to glucose. Predicted to be located in nucleoplasm. Predicted to be part of RecQ family helicase-topoisomerase III complex. Predicted to be active in nuclear body. Orthologous to human RMI1 (RecQ mediated genome instability 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.8), CNS E14 (RPKM 10.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 B1; 13 31.05 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (58550062..58558963)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (58402248..58411149)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene Q-nucleotide N-glycosylase 1 Neighboring gene heterogeneous nuclear ribonucleoprotein K Neighboring gene microRNA 7-1 Neighboring gene STARR-positive B cell enhancer ABC_E8893 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:58504005-58504114 Neighboring gene STARR-seq mESC enhancer starr_34681 Neighboring gene STARR-positive B cell enhancer ABC_E11546 Neighboring gene predicted gene, 33875 Neighboring gene predicted gene, 47918 Neighboring gene STARR-seq mESC enhancer starr_34684 Neighboring gene predicted gene, 40966

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Glucose regulates RMI1 expression through the E2F pathways in adipose cells. Suwa A, et al. Endocrine, 2011 Aug. PMID 21432623
  2. RMI1 attenuates tumor development and is essential for early embryonic survival. Chen H, et al. Mol Carcinog, 2011 Feb. PMID 21229605, Free PMC Article
  3. RMI1 deficiency in mice protects from diet and genetic-induced obesity. Suwa A, et al. FEBS J, 2010 Feb. PMID 20050919
  4. Genome instability and embryonic developmental defects in RMI1 deficient mice. Guiraldelli MF, et al. DNA Repair (Amst), 2013 Oct. PMID 23900276, Free PMC Article
  5. Role of replication protein A in double holliday junction dissolution mediated by the BLM-Topo IIIα-RMI1-RMI2 protein complex. Xue X, et al. J Biol Chem, 2013 May 17. PMID 23543748, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results demonstrate the importance of RMI1 in maintaining genome integrity and normal embryonic development
    Title: Genome instability and embryonic developmental defects in RMI1 deficient mice.
  2. Glucose regulates RMI1 expression through the E2F pathways in adipose cells.
    Title: Glucose regulates RMI1 expression through the E2F pathways in adipose cells.
  3. These results demonstrated a dual-role of RMI1 in embryonic development and tumor suppression.
    Title: RMI1 attenuates tumor development and is essential for early embryonic survival.
  4. results suggest that the regulation of energy balance by RMI1 is attributable to the regulation of food intake and E2F8 expression in adipose tissue.
    Title: RMI1 deficiency in mice protects from diet and genetic-induced obesity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within reduction of food intake in response to dietary excess IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in resolution of DNA recombination intermediates ISO
Inferred from Sequence Orthology
more info
  
involved_in resolution of meiotic recombination intermediates IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to dietary excess IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to glucose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RecQ family helicase-topoisomerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RecQ family helicase-topoisomerase III complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
recQ-mediated genome instability protein 1
Names
RMI1, RecQ mediated genome instability 1, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168248.2 → NP_001161720.1  recQ-mediated genome instability protein 1

    See identical proteins and their annotated locations for NP_001161720.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC154437
    Consensus CDS
    CCDS26571.1
    UniProtKB/Swiss-Prot
    Q8C560, Q8CI20, Q9D4G9
    Related
    ENSMUSP00000153621.2, ENSMUST00000225815.2
    Conserved Domains (2) summary
    pfam08585
    Location:14 → 204
    RMI1_N; RecQ mediated genome instability protein
    pfam16099
    Location:480 → 610
    RMI1_C; Recq-mediated genome instability protein 1, C-terminal OB-fold

  2. NM_028904.4 → NP_083180.3  recQ-mediated genome instability protein 1

    See identical proteins and their annotated locations for NP_083180.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC154437
    Consensus CDS
    CCDS26571.1
    UniProtKB/Swiss-Prot
    Q8C560, Q8CI20, Q9D4G9
    Related
    ENSMUSP00000041035.9, ENSMUST00000042450.10
    Conserved Domains (2) summary
    pfam08585
    Location:14 → 204
    RMI1_N; RecQ mediated genome instability protein
    pfam16099
    Location:480 → 610
    RMI1_C; Recq-mediated genome instability protein 1, C-terminal OB-fold

RNA

  1. NR_031761.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC154437, AK079457

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    58550062..58558963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517420.5 → XP_006517483.1  recQ-mediated genome instability protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006517483.1

    UniProtKB/Swiss-Prot
    Q8C560, Q8CI20, Q9D4G9
    Related
    ENSMUSP00000153050.2, ENSMUST00000224479.2
    Conserved Domains (2) summary
    pfam08585
    Location:14 → 204
    RMI1_N; RecQ mediated genome instability protein
    pfam16099
    Location:480 → 610
    RMI1_C; Recq-mediated genome instability protein 1, C-terminal OB-fold

  2. XM_036158198.1 → XP_036014091.1  recQ-mediated genome instability protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8C560, Q8CI20, Q9D4G9
    Conserved Domains (2) summary
    pfam08585
    Location:14 → 204
    RMI1_N; RecQ mediated genome instability protein
    pfam16099
    Location:480 → 610
    RMI1_C; Recq-mediated genome instability protein 1, C-terminal OB-fold
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D4G9.1 GenPept UniProtKB/Swiss-Prot:Q9D4G9

Gene LinkOut

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