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Polr3c polymerase (RNA) III (DNA directed) polypeptide C [ Mus musculus (house mouse) ]

Gene ID: 74414, updated on 9-May-2024

Summary

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Official Symbol
Polr3cprovided by MGI
Official Full Name
polymerase (RNA) III (DNA directed) polypeptide Cprovided by MGI
Primary source
MGI:MGI:1921664
See related
Ensembl:ENSMUSG00000028099 AllianceGenome:MGI:1921664
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RPC3; RPC62; 4933407E01Rik
Summary
Predicted to enable single-stranded DNA binding activity. Predicted to be involved in positive regulation of innate immune response and positive regulation of interferon-beta production. Predicted to act upstream of or within defense response to virus and innate immune response. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase III complex. Orthologous to human POLR3C (RNA polymerase III subunit C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 19.8), testis adult (RPKM 14.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F2.1; 3 41.96 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (96618836..96634803, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (96711520..96727498, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6084 Neighboring gene STARR-seq mESC enhancer starr_08444 Neighboring gene ankyrin repeat domain 35 Neighboring gene protein inhibitor of activated STAT 3 Neighboring gene nudix hydrolase 17 Neighboring gene STARR-positive B cell enhancer ABC_E6085 Neighboring gene predicted gene, 22581 Neighboring gene ring finger protein 115 Neighboring gene CD160 antigen

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genomic variants in an inbred mouse model predict mania-like behaviors. Saul MC, et al. PLoS One, 2018. PMID 29768498, Free PMC Article
  2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Spontaneous (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within defense response to virus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase III complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerase III subunit RPC3
Names
DNA-directed RNA polymerase III subunit C
RNA polymerase III subunit C3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028925.2 → NP_083201.1  DNA-directed RNA polymerase III subunit RPC3

    See identical proteins and their annotated locations for NP_083201.1

    Status: VALIDATED

    Source sequence(s)
    AC112261
    Consensus CDS
    CCDS51010.1
    UniProtKB/Swiss-Prot
    Q8R0I2, Q9D483
    UniProtKB/TrEMBL
    B2RX77
    Related
    ENSMUSP00000029741.3, ENSMUST00000029741.9
    Conserved Domains (2) summary
    pfam05645
    Location:146 → 344
    RNA_pol_Rpc82; RNA polymerase III subunit RPC82
    pfam08221
    Location:7 → 65
    HTH_9; RNA polymerase III subunit RPC82 helix-turn-helix domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    96618836..96634803 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502188.5 → XP_006502251.1  DNA-directed RNA polymerase III subunit RPC3 isoform X2

    Conserved Domains (1) summary
    pfam05645
    Location:62 → 260
    RNA_pol_Rpc82; RNA polymerase III subunit RPC82

  2. XM_030252855.2 → XP_030108715.1  DNA-directed RNA polymerase III subunit RPC3 isoform X2

    Conserved Domains (1) summary
    pfam05645
    Location:62 → 260
    RNA_pol_Rpc82; RNA polymerase III subunit RPC82

  3. XM_006502187.5 → XP_006502250.1  DNA-directed RNA polymerase III subunit RPC3 isoform X1

    See identical proteins and their annotated locations for XP_006502250.1

    UniProtKB/Swiss-Prot
    Q8R0I2, Q9D483
    UniProtKB/TrEMBL
    B2RX77
    Related
    ENSMUSP00000122435.2, ENSMUST00000154679.8
    Conserved Domains (2) summary
    pfam05645
    Location:146 → 344
    RNA_pol_Rpc82; RNA polymerase III subunit RPC82
    pfam08221
    Location:7 → 65
    HTH_9; RNA polymerase III subunit RPC82 helix-turn-helix domain

RNA

  1. XR_867239.4 RNA Sequence

  2. XR_375595.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D483.1 GenPept UniProtKB/Swiss-Prot:Q9D483

Gene LinkOut

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