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Pus10 pseudouridylate synthase 10 [ Mus musculus (house mouse) ]

Gene ID: 74467, updated on 12-May-2024

Summary

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Official Symbol
Pus10provided by MGI
Official Full Name
pseudouridylate synthase 10provided by MGI
Primary source
MGI:MGI:1921717
See related
Ensembl:ENSMUSG00000020280 AllianceGenome:MGI:1921717
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc139; 2810013G11Rik; 4933435A13Rik
Summary
Predicted to enable primary miRNA binding activity and tRNA pseudouridine synthase activity. Predicted to be involved in primary miRNA processing and tRNA pseudouridine synthesis. Predicted to act upstream of or within tRNA processing. Predicted to be located in cytoplasm and nucleus. Orthologous to human PUS10 (pseudouridine synthase 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.9), placenta adult (RPKM 5.2) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A3.2; 11 14.34 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (23608588..23682876)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (23658591..23732876)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28917 Neighboring gene selenoprotein K, pseudogene 1 Neighboring gene SANT and BTB domain regulator of CSR Neighboring gene peroxisomal biogenesis factor 13 Neighboring gene STARR-seq mESC enhancer starr_28923 Neighboring gene reticuloendotheliosis oncogene Neighboring gene STARR-seq mESC enhancer starr_28924 Neighboring gene predicted gene, 39612

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
  2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables primary miRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables pseudouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pseudouridine synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA pseudouridine synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA pseudouridine(55) synthase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA modification IEA
Inferred from Electronic Annotation
more info
  
involved_in primary miRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in pseudouridine synthesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA pseudouridine synthesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tRNA pseudouridine synthase Pus10
Names
coiled-coil domain containing 139
coiled-coil domain-containing protein 139
psi55 synthase
putative tRNA pseudouridine synthase Pus10
tRNA pseudouridine 55 synthase
tRNA pseudouridylate synthase
tRNA-uridine isomerase
NP_001028826.1
NP_001388067.1
NP_001388068.1
NP_001388069.1
NP_001388070.1
NP_001388071.1
NP_001388072.1
NP_001388073.1
NP_001388074.1
NP_001388075.1
NP_001388076.1
NP_001388077.1
NP_001388078.1
NP_001388079.1
NP_082580.1
NP_083232.1
XP_006514925.1
XP_006514926.1
XP_006514927.1
XP_006514928.2
XP_006514929.1
XP_030102254.1
XP_030102260.1
XP_036012942.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033654.3 → NP_001028826.1  tRNA pseudouridine synthase Pus10 isoform 1

    See identical proteins and their annotated locations for NP_001028826.1

    Status: VALIDATED

    Source sequence(s)
    AL672049, AL805916, BX255874
    Consensus CDS
    CCDS24479.1
    UniProtKB/Swiss-Prot
    Q3UM90, Q8BSZ4, Q8CDM2, Q9CSI7, Q9D3U0
    Related
    ENSMUSP00000105151.2, ENSMUST00000109525.8
    Conserved Domains (1) summary
    cl28383
    Location:286 → 521
    Pus10; tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis]

  2. NM_001401138.1 → NP_001388067.1  tRNA pseudouridine synthase Pus10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672049, AL805916, BX255874
    UniProtKB/Swiss-Prot
    Q3UM90, Q8BSZ4, Q8CDM2, Q9CSI7, Q9D3U0

  3. NM_001401139.1 → NP_001388068.1  tRNA pseudouridine synthase Pus10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672049, AL805916, BX255874
    UniProtKB/Swiss-Prot
    Q3UM90, Q8BSZ4, Q8CDM2, Q9CSI7, Q9D3U0

  4. NM_001401140.1 → NP_001388069.1  tRNA pseudouridine synthase Pus10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672049, AL805916, BX255874
    UniProtKB/Swiss-Prot
    Q3UM90, Q8BSZ4, Q8CDM2, Q9CSI7, Q9D3U0

  5. NM_001401141.1 → NP_001388070.1  tRNA pseudouridine synthase Pus10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672049, AL805916, BX255874

  6. NM_001401142.1 → NP_001388071.1  tRNA pseudouridine synthase Pus10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL672049, AL805916, BX255874

  7. NM_001401143.1 → NP_001388072.1  tRNA pseudouridine synthase Pus10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL672049, AL805916, BX255874

  8. NM_001401144.1 → NP_001388073.1  tRNA pseudouridine synthase Pus10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL805916, BX255874

  9. NM_001401145.1 → NP_001388074.1  tRNA pseudouridine synthase Pus10 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL805916, BX255874

  10. NM_001401146.1 → NP_001388075.1  tRNA pseudouridine synthase Pus10 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL805916, BX255874

  11. NM_001401147.1 → NP_001388076.1  tRNA pseudouridine synthase Pus10 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL672049, AL805916, BX255874

  12. NM_001401148.1 → NP_001388077.1  tRNA pseudouridine synthase Pus10 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL672049, AL805916, BX255874

  13. NM_001401149.1 → NP_001388078.1  tRNA pseudouridine synthase Pus10 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL805916, BX255874

  14. NM_001401150.1 → NP_001388079.1  tRNA pseudouridine synthase Pus10 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL805916, BX255874

  15. NM_028304.4 → NP_082580.1  tRNA pseudouridine synthase Pus10 isoform 1

    See identical proteins and their annotated locations for NP_082580.1

    Status: VALIDATED

    Source sequence(s)
    AL672049, AL805916, BX255874
    Consensus CDS
    CCDS24479.1
    UniProtKB/Swiss-Prot
    Q3UM90, Q8BSZ4, Q8CDM2, Q9CSI7, Q9D3U0
    Related
    ENSMUSP00000050395.5, ENSMUST00000058163.11
    Conserved Domains (1) summary
    cl28383
    Location:286 → 521
    Pus10; tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis]

  16. NM_028956.5 → NP_083232.1  tRNA pseudouridine synthase Pus10 isoform 1

    See identical proteins and their annotated locations for NP_083232.1

    Status: VALIDATED

    Source sequence(s)
    AL672049, AL805916, BX255874
    Consensus CDS
    CCDS24479.1
    UniProtKB/Swiss-Prot
    Q3UM90, Q8BSZ4, Q8CDM2, Q9CSI7, Q9D3U0
    Related
    ENSMUSP00000020520.5, ENSMUST00000020520.11
    Conserved Domains (1) summary
    cl28383
    Location:286 → 521
    Pus10; tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis]

RNA

  1. NR_156455.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL672049, AL805916, BX255874

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    23608588..23682876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246400.2 → XP_030102260.1  tRNA pseudouridine synthase Pus10 isoform X5

  2. XM_006514865.5 → XP_006514928.2  tRNA pseudouridine synthase Pus10 isoform X1

    Conserved Domains (1) summary
    cl28383
    Location:437 → 685
    Pus10; tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis]

  3. XM_030246394.2 → XP_030102254.1  tRNA pseudouridine synthase Pus10 isoform X2

    Conserved Domains (1) summary
    cl28383
    Location:437 → 684
    Pus10; tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis]

  4. XM_006514862.4 → XP_006514925.1  tRNA pseudouridine synthase Pus10 isoform X3

    See identical proteins and their annotated locations for XP_006514925.1

    Conserved Domains (1) summary
    cl28383
    Location:286 → 534
    Pus10; tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis]

  5. XM_006514864.3 → XP_006514927.1  tRNA pseudouridine synthase Pus10 isoform X3

    See identical proteins and their annotated locations for XP_006514927.1

    Conserved Domains (1) summary
    cl28383
    Location:286 → 534
    Pus10; tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis]

  6. XM_006514863.3 → XP_006514926.1  tRNA pseudouridine synthase Pus10 isoform X3

    See identical proteins and their annotated locations for XP_006514926.1

    Conserved Domains (1) summary
    cl28383
    Location:286 → 534
    Pus10; tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis]

  7. XM_006514866.4 → XP_006514929.1  tRNA pseudouridine synthase Pus10 isoform X3

    See identical proteins and their annotated locations for XP_006514929.1

    Conserved Domains (1) summary
    cl28383
    Location:286 → 534
    Pus10; tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis]

  8. XM_036157049.1 → XP_036012942.1  tRNA pseudouridine synthase Pus10 isoform X7

    Conserved Domains (1) summary
    cl28383
    Location:122 → 357
    Pus10; tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis]

RNA

  1. XR_003949523.2 RNA Sequence

  2. XR_003949522.2 RNA Sequence

  3. XR_003949520.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D3U0.1 GenPept UniProtKB/Swiss-Prot:Q9D3U0

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