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Osbpl10 oxysterol binding protein-like 10 [ Mus musculus (house mouse) ]

Gene ID: 74486, updated on 11-Apr-2024

Summary

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Official Symbol
Osbpl10provided by MGI
Official Full Name
oxysterol binding protein-like 10provided by MGI
Primary source
MGI:MGI:1921736
See related
Ensembl:ENSMUSG00000040875 AllianceGenome:MGI:1921736
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OPR-10; ORP-10; 4933433D06Rik; C820004B04Rik
Summary
Predicted to enable cholesterol binding activity; phosphatidylserine binding activity; and sterol transporter activity. Predicted to act upstream of or within lipid metabolic process and lipid transport. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in cytosol; intracellular membrane-bounded organelle; and membrane. Is expressed in several structures, including genitourinary system; heart; immune system; lung; and nervous system. Orthologous to human OSBPL10 (oxysterol binding protein like 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 17.5), small intestine adult (RPKM 2.8) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F3; 9 66.84 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (114807531..115062341)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (114978485..115233273)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30448 Neighboring gene STARR-positive B cell enhancer ABC_E6808 Neighboring gene glycerol-3-phosphate dehydrogenase 1-like Neighboring gene ribosomal protein S27, retrogene Neighboring gene STARR-seq mESC enhancer starr_25396 Neighboring gene STARR-seq mESC enhancer starr_25397 Neighboring gene STARR-positive B cell enhancer mm9_chr9:114953001-114953302 Neighboring gene predicted gene 4665 Neighboring gene predicted gene, 53513 Neighboring gene predicted gene, 26962 Neighboring gene STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae) Neighboring gene stathmin 1, related sequence 1 Neighboring gene STARR-positive B cell enhancer mm9_chr9:115217576-115217877 Neighboring gene STARR-positive B cell enhancer ABC_E1395 Neighboring gene RIKEN cDNA 4930428G15 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An oxysterol-binding protein family identified in the mouse. Anniss AM, et al. DNA Cell Biol, 2002 Aug. PMID 12215260
  2. The Vertebrate Genome Annotation browser 10 years on. Harrow JL, et al. Nucleic Acids Res, 2014 Jan. PMID 24316575, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
oxysterol-binding protein-related protein 10
Names
OSBP-related protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_148958.3 → NP_683761.2  oxysterol-binding protein-related protein 10

    Status: VALIDATED

    Source sequence(s)
    AC157586, AC160132, AC162179
    Consensus CDS
    CCDS40796.2
    UniProtKB/Swiss-Prot
    Q8R2T7, S4R1M9
    Related
    ENSMUSP00000138287.2, ENSMUST00000183104.8
    Conserved Domains (3) summary
    cd13291
    Location:79 → 185
    PH_ORP10_ORP11; Human Oxysterol binding protein (OSBP) related proteins 10 and 11 (ORP10 and ORP11) Pleckstrin homology (PH) domain
    pfam01237
    Location:404 → 764
    Oxysterol_BP; Oxysterol-binding protein
    pfam10428
    Location:179 → 318
    SOG2; RAM signalling pathway protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    114807531..115062341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512377.4 → XP_006512440.1  oxysterol-binding protein-related protein 10 isoform X8

    Conserved Domains (1) summary
    cd13291
    Location:79 → 185
    PH_ORP10_ORP11; Human Oxysterol binding protein (OSBP) related proteins 10 and 11 (ORP10 and ORP11) Pleckstrin homology (PH) domain

  2. XM_006512371.4 → XP_006512434.1  oxysterol-binding protein-related protein 10 isoform X2

    Conserved Domains (2) summary
    cd13291
    Location:79 → 181
    PH_ORP10_ORP11; Human Oxysterol binding protein (OSBP) related proteins 10 and 11 (ORP10 and ORP11) Pleckstrin homology (PH) domain
    pfam01237
    Location:340 → 700
    Oxysterol_BP; Oxysterol-binding protein

  3. XM_011243052.4 → XP_011241354.1  oxysterol-binding protein-related protein 10 isoform X3

    UniProtKB/TrEMBL
    A0A0R4J0F9
    Conserved Domains (2) summary
    pfam01237
    Location:310 → 670
    Oxysterol_BP; Oxysterol-binding protein
    cl17171
    Location:2 → 91
    PH-like; Pleckstrin homology-like domain

  4. XM_006512372.4 → XP_006512435.1  oxysterol-binding protein-related protein 10 isoform X4

    See identical proteins and their annotated locations for XP_006512435.1

    UniProtKB/TrEMBL
    A0A0R4J0F9, S4R296
    Conserved Domains (2) summary
    pfam01237
    Location:265 → 625
    Oxysterol_BP; Oxysterol-binding protein
    cl17171
    Location:1 → 46
    PH-like; Pleckstrin homology-like domain

  5. XM_006512373.5 → XP_006512436.1  oxysterol-binding protein-related protein 10 isoform X4

    See identical proteins and their annotated locations for XP_006512436.1

    UniProtKB/TrEMBL
    A0A0R4J0F9, S4R296
    Related
    ENSMUSP00000138552.2, ENSMUST00000182384.8
    Conserved Domains (2) summary
    pfam01237
    Location:265 → 625
    Oxysterol_BP; Oxysterol-binding protein
    cl17171
    Location:1 → 46
    PH-like; Pleckstrin homology-like domain

  6. XM_011243051.4 → XP_011241353.1  oxysterol-binding protein-related protein 10 isoform X1

    UniProtKB/TrEMBL
    A0A0R4J0F9
    Conserved Domains (2) summary
    pfam01237
    Location:346 → 706
    Oxysterol_BP; Oxysterol-binding protein
    cl17171
    Location:37 → 127
    PH-like; Pleckstrin homology-like domain

  7. XM_006512374.3 → XP_006512437.1  oxysterol-binding protein-related protein 10 isoform X5

    UniProtKB/TrEMBL
    A0A0R4J0F9
    Conserved Domains (1) summary
    pfam01237
    Location:264 → 624
    Oxysterol_BP; Oxysterol-binding protein

  8. XM_036155361.1 → XP_036011254.1  oxysterol-binding protein-related protein 10 isoform X6

    UniProtKB/TrEMBL
    A0A0R4J0F9
    Conserved Domains (1) summary
    pfam01237
    Location:200 → 560
    Oxysterol_BP; Oxysterol-binding protein

  9. XM_006512376.5 → XP_006512439.1  oxysterol-binding protein-related protein 10 isoform X7

    Conserved Domains (1) summary
    pfam01237
    Location:118 → 478
    Oxysterol_BP; Oxysterol-binding protein

RNA

  1. XR_003948042.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_176901.2: Suppressed sequence

    Description
    NM_176901.2: This RefSeq was removed because the transcript is partial.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
S4R1M9.1 GenPept UniProtKB/Swiss-Prot:S4R1M9

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