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SMAD3 SMAD family member 3 [ Pan troglodytes (chimpanzee) ]

Gene ID: 748161, updated on 3-Apr-2024

Summary

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Official Symbol
SMAD3provided by VGNC
Official Full Name
SMAD family member 3provided by VGNC
Primary source
VGNC:VGNC:1877
Locus tag
CK820_G0008233
See related
Ensembl:ENSPTRG00000007199
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 15
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 16 NC_072414.2 (59059716..59189183)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 15 NC_072413.1 (59034569..59164036)

Chromosome 16 - NC_072414.2Genomic Context describing neighboring genes Neighboring gene mitochondrial proton/calcium exchanger protein-like Neighboring gene uncharacterized LOC104002349 Neighboring gene uncharacterized LOC134808549 Neighboring gene small ribosomal subunit protein eS24-like Neighboring gene alpha and gamma adaptin binding protein Neighboring gene IQ motif containing H Neighboring gene uncharacterized LOC104002350

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables I-SMAD binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in SMAD protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in activin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of heteromeric SMAD protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
mothers against decapentaplegic homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072414.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    59059716..59189183
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001159972.7 → XP_001159972.2  mothers against decapentaplegic homolog 3 isoform X1

    See identical proteins and their annotated locations for XP_001159972.2

    UniProtKB/TrEMBL
    A0A2I3TN10, A0A2J8NR65, A0A6D2WIA6, H2Q9N8
    Related
    ENSPTRP00000012319.2
    Conserved Domains (2) summary
    cd10491
    Location:8 → 132
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:224 → 414
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

  2. XM_054667735.2 → XP_054523710.1  mothers against decapentaplegic homolog 3 isoform X4

  3. XM_054667736.2 → XP_054523711.1  mothers against decapentaplegic homolog 3 isoform X5

  4. XM_003314725.7 → XP_003314773.1  mothers against decapentaplegic homolog 3 isoform X3

    See identical proteins and their annotated locations for XP_003314773.1

    UniProtKB/TrEMBL
    A0A2I3SCV4, A0A2J8NR40
    Conserved Domains (2) summary
    cd10985
    Location:119 → 309
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    cl00055
    Location:1 → 27
    MH1; N-terminal Mad Homology 1 (MH1) domain

  5. XM_003314726.7 → XP_003314774.1  mothers against decapentaplegic homolog 3 isoform X2

    See identical proteins and their annotated locations for XP_003314774.1

    UniProtKB/TrEMBL
    A0A2I3RPL6, A0A2J8NR50, A0A6D2W4H2, K7CGG0
    Related
    ENSPTRP00000063072.1
    Conserved Domains (2) summary
    cd10985
    Location:180 → 370
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    cl00055
    Location:25 → 88
    MH1; N-terminal Mad Homology 1 (MH1) domain
Nucleotide Protein
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