Amotl1 angiomotin-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Amotl1provided by MGI
Official Full Name: angiomotin-like 1provided by MGI
Primary source: MGI:MGI:1922973
See related: Ensembl:ENSMUSG00000013076 AllianceGenome:MGI:1922973
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: JEAP; mFLJ00155; 2310010G08Rik; 2310067L22Rik; 4932416D09Rik
Summary: Predicted to enable identical protein binding activity. Acts upstream of or within establishment of cell polarity involved in ameboidal cell migration and positive regulation of blood vessel endothelial cell migration. Located in several cellular components, including apical plasma membrane; bicellular tight junction; and lamellipodium. Is expressed in brain and head. Orthologous to human AMOTL1 (angiomotin like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 21.7), mammary gland adult (RPKM 16.7) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A2; 9 4.12 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (14453262..14574408, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (14541966..14662974, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fat4 is not required for the canonical activation of Hippo kinases but it sequesters a partner of Yap1, Amotl1, out of the nucleus.
Title: Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth.
The authors propose that AmotL1 is an essential effector of the N-cadherin mediated endothelial/pericyte junctional complex.
Title: Angiomotin like-1 is a novel component of the N-cadherin complex affecting endothelial/pericyte interaction in normal and tumor angiogenesis.
These results suggested that IFN-gamma exhibits anti-angiogenesis effects by regulating the expression of TNF-alpha-induced AmotL1 via NFkappaB in emphysema lungs.
Title: The role of tumor necrosis factor-α and interferon-γ in regulating angiomotin-like protein 1 expression in lung microvascular endothelial cells.
Amot, Amotl1, and Amotl2 are differentially expressed in uterine cells during the peri-implantation period.
Title: Differential expression of the motin family in the peri-implantation mouse uterus and their hormonal regulation.
Amot and AmotL1 have similar effects on endothelial migration and tight junction formation in vitro. In vivo Amot appears to control the cell polarity and AmotL1 affects the stability of cell-cell junctions.
Title: Angiomotin-like protein 1 controls endothelial polarity and junction stability during sprouting angiogenesis.
Data show that MUPP1 interacts with angiomotin (Amot), JEAP/Amot-like 1 and MASCOT/Amot-like 2, and that all the Amot/JEAP family proteins also interacted with Patj, a close relative of MUPP1.
Title: Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048745 (e-PCR)
- UniSTS:145195

D9Mit61 (e-PCR), detects polymorphism
- UniSTS:131948

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of blood vessel endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of cell polarity involved in ameboidal cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of cell polarity involved in ameboidal cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of epithelial cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hippo signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of blood vessel endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: angiomotin-like protein 1

Names: junction-enriched and -associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081395.1 → NP_001074864.1 angiomotin-like protein 1

See identical proteins and their annotated locations for NP_001074864.1

Status: PROVISIONAL

Source sequence(s)

CT030247, CT485607

Consensus CDS

CCDS40535.1

UniProtKB/Swiss-Prot

B9EKN5, Q571F1, Q9D4H4

Related

ENSMUSP00000013220.7, ENSMUST00000013220.8

Conserved Domains (3) summary

pfam12240
Location:616 → 818

Angiomotin_C; Angiomotin C terminal

cl02475
Location:16 → 51

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

cl12013
Location:478 → 650

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

14453262..14574408 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510666.4 → XP_006510729.1 angiomotin-like protein 1 isoform X2

UniProtKB/TrEMBL

A0A1Y7VM69

Related

ENSMUSP00000152834.2, ENSMUST00000223132.2

Conserved Domains (2) summary

COG1196
Location:486 → 741

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12240
Location:653 → 855

Angiomotin_C; Angiomotin C terminal
XM_036155371.1 → XP_036011264.1 angiomotin-like protein 1 isoform X4

Conserved Domains (2) summary

TIGR02169
Location:358 → 619

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam12240
Location:530 → 736

Angiomotin_C; Angiomotin C terminal
XM_006510667.4 → XP_006510730.1 angiomotin-like protein 1 isoform X1

Conserved Domains (2) summary

COG1196
Location:485 → 740

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12240
Location:652 → 854

Angiomotin_C; Angiomotin C terminal
XM_030244693.2 → XP_030100553.1 angiomotin-like protein 1 isoform X4

Conserved Domains (2) summary

TIGR02169
Location:358 → 619

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam12240
Location:530 → 736

Angiomotin_C; Angiomotin C terminal
XM_006510670.3 → XP_006510733.1 angiomotin-like protein 1 isoform X4

See identical proteins and their annotated locations for XP_006510733.1

UniProtKB/Swiss-Prot

Q9D4H4

Conserved Domains (2) summary

TIGR02169
Location:358 → 619

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam12240
Location:530 → 736

Angiomotin_C; Angiomotin C terminal
XM_006510668.2 → XP_006510731.1 angiomotin-like protein 1 isoform X4

See identical proteins and their annotated locations for XP_006510731.1

UniProtKB/Swiss-Prot

Q9D4H4

Conserved Domains (2) summary

TIGR02169
Location:358 → 619

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam12240
Location:530 → 736

Angiomotin_C; Angiomotin C terminal
XM_030244692.2 → XP_030100552.1 angiomotin-like protein 1 isoform X3

Conserved Domains (3) summary

COG1196
Location:448 → 703

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl02475
Location:16 → 51

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

pfam12240
Location:615 → 817

Angiomotin_C; Angiomotin C terminal
XM_006510669.4 → XP_006510732.1 angiomotin-like protein 1 isoform X4

See identical proteins and their annotated locations for XP_006510732.1

UniProtKB/Swiss-Prot

Q9D4H4

Conserved Domains (2) summary

TIGR02169
Location:358 → 619

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam12240
Location:530 → 736

Angiomotin_C; Angiomotin C terminal