Rbmxl2 RNA binding motif protein, X-linked-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rbmxl2provided by MGI
Official Full Name: RNA binding motif protein, X-linked-like 2provided by MGI
Primary source: MGI:MGI:1923822
See related: Ensembl:ENSMUSG00000073894 AllianceGenome:MGI:1923822
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hnrnpg-t; 1700012H05Rik
Summary: Predicted to be involved in positive regulation of mRNA splicing, via spliceosome. Predicted to be part of spliceosomal complex. Is expressed in central nervous system and sensory organ. Orthologous to several human genes including RBMXL2 (RBMX like 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 7 E3; 7 56.1 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (106808652..106810123)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (107209445..107210916)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rbmxl2 retrogene has been conserved across mammals as part of a splicing control mechanism that is fundamentally important to germ cell biology.
Title: An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning.
Haploinsufficiency of hnRNPGT results in abnormal sperm production in the mouse.
Title: Haploinsufficiency of the germ cell-specific nuclear RNA binding protein hnRNP G-T prevents functional spermatogenesis in the mouse.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rbmxl2 (e-PCR), detects polymorphism
- UniSTS:479143

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of spliceosomal complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RNA-binding motif protein, X-linked-like-2

Names: testes-specific heterogenous nuclear ribonucleoprotein G-T

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029660.2 → NP_083936.1 RNA-binding motif protein, X-linked-like-2

See identical proteins and their annotated locations for NP_083936.1

Status: PROVISIONAL

Source sequence(s)

AK005907

Consensus CDS

CCDS21689.1

UniProtKB/TrEMBL

Q9DAE2

Related

ENSMUSP00000095739.2, ENSMUST00000098135.2

Conserved Domains (3) summary

COG0724
Location:9 → 81

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12382
Location:7 → 86

RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

pfam08081
Location:170 → 214

RBM1CTR; RBM1CTR (NUC064) family