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Mib2 mindbomb E3 ubiquitin protein ligase 2 [ Mus musculus (house mouse) ]

Gene ID: 76580, updated on 12-May-2024

Summary

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Official Symbol
Mib2provided by MGI
Official Full Name
mindbomb E3 ubiquitin protein ligase 2provided by MGI
Primary source
MGI:MGI:2679684
See related
Ensembl:ENSMUSG00000029060 AllianceGenome:MGI:2679684
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
skd; Zzank1; 2210008I11Rik
Summary
Enables ubiquitin protein ligase activity. Acts upstream of or within protein ubiquitination. Located in early endosome. Part of ubiquitin ligase complex. Is expressed in several structures, including 4th ventricle choroid plexus; genitourinary system; gut; hair follicle; and hemolymphoid system gland. Orthologous to human MIB2 (MIB E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 36.2), adrenal adult (RPKM 23.1) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Mib2 in Genome Data Viewer
Location:
4 E2; 4 86.86 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155738925..155753711, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155654468..155669254, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member E2 Neighboring gene predicted gene 16023 Neighboring gene cyclin dependent kinase 11B Neighboring gene matrix metallopeptidase 23 Neighboring gene STARR-seq mESC enhancer starr_12269 Neighboring gene STARR-seq mESC enhancer starr_12270 Neighboring gene STARR-seq mESC enhancer starr_12271 Neighboring gene STARR-positive B cell enhancer ABC_E6297 Neighboring gene fibronectin type III domain containing 10 Neighboring gene STARR-seq mESC enhancer starr_12272 Neighboring gene Ssu72 RNA polymerase II CTD phosphatase homolog (yeast) Neighboring gene predicted gene, 22573

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mind Bomb-2 Regulates Hippocampus-dependent Memory Formation and Synaptic Plasticity. Kim S, et al. Korean J Physiol Pharmacol, 2015 Nov. PMID 26557018, Free PMC Article
  2. PD-L1 translocation to the plasma membrane enables tumor immune evasion through MIB2 ubiquitination. Yu X, et al. J Clin Invest, 2023 Feb 1. PMID 36719382, Free PMC Article
  3. Participation of Mind Bomb-2 in Sevoflurane Anesthesia Induces Cognitive Impairment in Aged Mice via Modulating Ferroptosis. Zhao L, et al. ACS Chem Neurosci, 2021 Jul 7. PMID 34121396
  4. Targeted disruption of Mib2 causes exencephaly with a variable penetrance. Wu JI, et al. Genesis, 2007 Nov. PMID 17987667
  5. Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2. Li R, et al. Nat Commun, 2023 Apr 8. PMID 37031213, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PD-L1 translocation to the plasma membrane enables tumor immune evasion through MIB2 ubiquitination.
    Title: PD-L1 translocation to the plasma membrane enables tumor immune evasion through MIB2 ubiquitination.
  2. identify MIB2 as a novel component of the activated BCL10 signaling complex and a missing link in the BCL10-dependent NF-kappaB signaling pathway.
    Title: The E3 ubiquitin ligase mind bomb-2 (MIB2) protein controls B-cell CLL/lymphoma 10 (BCL10)-dependent NF-κB activation.
  3. created a targeted mutation of Mib2 and show that its phenotype is a variable penetrance, failure to close the cranial neural tube
    Title: Targeted disruption of Mib2 causes exencephaly with a variable penetrance.
  4. Mib2 has functional similarities to Mib1, but might have distinct roles in Notch signaling as an E3 ubiquitin ligase
    Title: Mind bomb-2 is an E3 ligase for Notch ligand.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase MIB2
Names
RING-type E3 ubiquitin transferase MIB2
dyslike
dystrophin-like protein
mind bomb-2
mindbomb homolog 2
skeletrophin
zinc finger, ZZ type with ankyrin repeat domain 1
NP_001243036.1
NP_001243037.2
NP_001356090.1
NP_001356091.1
NP_001356092.1
NP_001356093.1
NP_001356094.1
NP_001356095.1
NP_001356096.1
NP_001356097.1
NP_660106.2
XP_006539310.1
XP_006539312.1
XP_006539314.1
XP_006539317.1
XP_006539318.1
XP_011248655.1
XP_017175926.1
XP_030109739.1
XP_030109740.1
XP_030109741.1
XP_030109742.1
XP_030109743.1
XP_036020422.1
XP_036020423.1
XP_036020424.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256107.1 → NP_001243036.1  E3 ubiquitin-protein ligase MIB2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variant 4, encodes isoform 1.
    Source sequence(s)
    AI837194, AK147940, AK159611, CJ076202
    UniProtKB/Swiss-Prot
    A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
    Conserved Domains (9) summary
    PLN03192
    Location:424 → 488
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:457 → 708
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:89 → 133
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:461 → 491
    ANK; ANK repeat [structural motif]
    cd00162
    Location:909 → 941
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd16726
    Location:829 → 865
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    pfam06701
    Location:160 → 224
    MIB_HERC2; Mib_herc2
    pfam18346
    Location:324 → 388
    SH3_15; Mind bomb SH3 repeat domain
    cl17238
    Location:908 → 953
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. NM_001256108.2 → NP_001243037.2  E3 ubiquitin-protein ligase MIB2 isoform 2

    See identical proteins and their annotated locations for NP_001243037.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1. Variants 2, 3, 5, and 6 all encode the same isoform (2).
    Source sequence(s)
    AI837194, AK147940, AK159611, CJ076202
    Consensus CDS
    CCDS19035.1
    UniProtKB/Swiss-Prot
    A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
    Conserved Domains (7) summary
    PLN03192
    Location:392 → 456
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:425 → 676
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:89 → 133
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:429 → 459
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:160 → 224
    MIB_HERC2; Mib_herc2
    cd16726
    Location:797 → 833
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    cl17238
    Location:876 → 921
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. NM_001369161.1 → NP_001356090.1  E3 ubiquitin-protein ligase MIB2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variant 1, encodes isoform 1.
    Source sequence(s)
    AL627405
    UniProtKB/Swiss-Prot
    A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
    Conserved Domains (9) summary
    PLN03192
    Location:424 → 488
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:457 → 708
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:89 → 133
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:461 → 491
    ANK; ANK repeat [structural motif]
    cd00162
    Location:909 → 941
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd16726
    Location:829 → 865
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    pfam06701
    Location:160 → 224
    MIB_HERC2; Mib_herc2
    pfam18346
    Location:324 → 388
    SH3_15; Mind bomb SH3 repeat domain
    cl17238
    Location:908 → 953
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  4. NM_001369162.1 → NP_001356091.1  E3 ubiquitin-protein ligase MIB2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 2, 3, and 6, encodes isoform 2.
    Source sequence(s)
    AL627405
    Consensus CDS
    CCDS19035.1
    UniProtKB/Swiss-Prot
    A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
    Conserved Domains (7) summary
    PLN03192
    Location:392 → 456
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:425 → 676
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:89 → 133
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:429 → 459
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:160 → 224
    MIB_HERC2; Mib_herc2
    cd16726
    Location:797 → 833
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    cl17238
    Location:876 → 921
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  5. NM_001369163.1 → NP_001356092.1  E3 ubiquitin-protein ligase MIB2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 2, 3, and 5, encodes isoform 2.
    Source sequence(s)
    AL627405
    Consensus CDS
    CCDS19035.1
    UniProtKB/Swiss-Prot
    A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
    Conserved Domains (7) summary
    PLN03192
    Location:392 → 456
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:425 → 676
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:89 → 133
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:429 → 459
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:160 → 224
    MIB_HERC2; Mib_herc2
    cd16726
    Location:797 → 833
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    cl17238
    Location:876 → 921
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  6. NM_001369164.1 → NP_001356093.1  E3 ubiquitin-protein ligase MIB2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 8, encodes the longest isoform (3).
    Source sequence(s)
    AL627405
    UniProtKB/Swiss-Prot
    A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
    Conserved Domains (9) summary
    PLN03192
    Location:428 → 492
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:461 → 712
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:89 → 133
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:465 → 495
    ANK; ANK repeat [structural motif]
    cd00162
    Location:913 → 945
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd16726
    Location:833 → 869
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    pfam06701
    Location:160 → 224
    MIB_HERC2; Mib_herc2
    pfam18346
    Location:328 → 392
    SH3_15; Mind bomb SH3 repeat domain
    cl17238
    Location:912 → 957
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  7. NM_001369165.1 → NP_001356094.1  E3 ubiquitin-protein ligase MIB2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variant 7, encodes the longest isoform (3).
    Source sequence(s)
    AL627405
    UniProtKB/Swiss-Prot
    A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
    Conserved Domains (9) summary
    PLN03192
    Location:428 → 492
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:461 → 712
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:89 → 133
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:465 → 495
    ANK; ANK repeat [structural motif]
    cd00162
    Location:913 → 945
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd16726
    Location:833 → 869
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    pfam06701
    Location:160 → 224
    MIB_HERC2; Mib_herc2
    pfam18346
    Location:328 → 392
    SH3_15; Mind bomb SH3 repeat domain
    cl17238
    Location:912 → 957
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  8. NM_001369166.1 → NP_001356095.1  E3 ubiquitin-protein ligase MIB2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL627405
    UniProtKB/Swiss-Prot
    A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
    Conserved Domains (8) summary
    PLN03192
    Location:323 → 387
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:356 → 607
    PHA03095; ankyrin-like protein; Provisional
    pfam10921
    Location:154 → 232
    DUF2710; Protein of unknown function (DUF2710)
    sd00045
    Location:360 → 390
    ANK; ANK repeat [structural motif]
    cl00295
    Location:1 → 32
    ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
    pfam06701
    Location:59 → 123
    MIB_HERC2; Mib_herc2
    cd16726
    Location:728 → 764
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    cl17238
    Location:807 → 852
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  9. NM_001369167.1 → NP_001356096.1  E3 ubiquitin-protein ligase MIB2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL627405
    UniProtKB/Swiss-Prot
    A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
    Conserved Domains (5) summary
    PLN03192
    Location:428 → 492
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:461 → 712
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:89 → 133
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:465 → 495
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:160 → 224
    MIB_HERC2; Mib_herc2

  10. NM_001369168.1 → NP_001356097.1  E3 ubiquitin-protein ligase MIB2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL627405
    Conserved Domains (5) summary
    PLN03192
    Location:392 → 456
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:425 → 676
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:89 → 133
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:429 → 459
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:160 → 224
    MIB_HERC2; Mib_herc2

  11. NM_145124.3 → NP_660106.2  E3 ubiquitin-protein ligase MIB2 isoform 2

    See identical proteins and their annotated locations for NP_660106.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1. Variants 2, 3, 5, and 6 all encode the same isoform (2).
    Source sequence(s)
    AI837194, AK147940, AK159611, CJ076202
    Consensus CDS
    CCDS19035.1
    UniProtKB/Swiss-Prot
    A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
    Related
    ENSMUSP00000099465.4, ENSMUST00000103176.10
    Conserved Domains (7) summary
    PLN03192
    Location:392 → 456
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:425 → 676
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:89 → 133
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:429 → 459
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:160 → 224
    MIB_HERC2; Mib_herc2
    cd16726
    Location:797 → 833
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    cl17238
    Location:876 → 921
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    155738925..155753711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253881.1 → XP_030109741.1  E3 ubiquitin-protein ligase MIB2 isoform X5

    UniProtKB/Swiss-Prot
    A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
    UniProtKB/TrEMBL
    B2RUG2
    Conserved Domains (8) summary
    PLN03192
    Location:417 → 481
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:450 → 701
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:89 → 133
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:454 → 484
    ANK; ANK repeat [structural motif]
    cd16726
    Location:822 → 858
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    pfam06701
    Location:160 → 224
    MIB_HERC2; Mib_herc2
    pfam18346
    Location:292 → 356
    SH3_15; Mind bomb SH3 repeat domain
    cl17238
    Location:901 → 946
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_030253880.1 → XP_030109740.1  E3 ubiquitin-protein ligase MIB2 isoform X2

    UniProtKB/Swiss-Prot
    A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
    Conserved Domains (9) summary
    PLN03192
    Location:449 → 513
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:482 → 733
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:89 → 133
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:486 → 516
    ANK; ANK repeat [structural motif]
    cd00162
    Location:934 → 966
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd16726
    Location:854 → 890
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    pfam06701
    Location:160 → 224
    MIB_HERC2; Mib_herc2
    pfam18346
    Location:324 → 388
    SH3_15; Mind bomb SH3 repeat domain
    cl17238
    Location:933 → 978
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. XM_006539247.2 → XP_006539310.1  E3 ubiquitin-protein ligase MIB2 isoform X1

    See identical proteins and their annotated locations for XP_006539310.1

    UniProtKB/Swiss-Prot
    A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
    Conserved Domains (9) summary
    PLN03192
    Location:453 → 517
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:486 → 737
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:89 → 133
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:490 → 520
    ANK; ANK repeat [structural motif]
    cd00162
    Location:938 → 970
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd16726
    Location:858 → 894
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    pfam06701
    Location:160 → 224
    MIB_HERC2; Mib_herc2
    pfam18346
    Location:328 → 392
    SH3_15; Mind bomb SH3 repeat domain
    cl17238
    Location:937 → 982
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  4. XM_030253883.1 → XP_030109743.1  E3 ubiquitin-protein ligase MIB2 isoform X9

    UniProtKB/Swiss-Prot
    A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
    Conserved Domains (9) summary
    PLN03192
    Location:291 → 355
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:324 → 575
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:328 → 358
    ANK; ANK repeat [structural motif]
    cl00295
    Location:1 → 32
    ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
    cd00162
    Location:776 → 808
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd16726
    Location:696 → 732
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    pfam06701
    Location:59 → 123
    MIB_HERC2; Mib_herc2
    pfam18346
    Location:191 → 255
    SH3_15; Mind bomb SH3 repeat domain
    cl17238
    Location:775 → 820
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  5. XM_036164531.1 → XP_036020424.1  E3 ubiquitin-protein ligase MIB2 isoform X7

    UniProtKB/Swiss-Prot
    A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
    Conserved Domains (9) summary
    PLN03192
    Location:316 → 380
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:349 → 600
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:353 → 383
    ANK; ANK repeat [structural motif]
    cd00162
    Location:801 → 833
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd16726
    Location:721 → 757
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    pfam06701
    Location:59 → 123
    MIB_HERC2; Mib_herc2
    pfam18346
    Location:191 → 255
    SH3_15; Mind bomb SH3 repeat domain
    cl00295
    Location:1 → 32
    ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
    cl17238
    Location:800 → 845
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  6. XM_006539255.2 → XP_006539318.1  E3 ubiquitin-protein ligase MIB2 isoform X6

    UniProtKB/Swiss-Prot
    A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
    Conserved Domains (9) summary
    PLN03192
    Location:352 → 416
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:385 → 636
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:389 → 419
    ANK; ANK repeat [structural motif]
    cl00295
    Location:1 → 32
    ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
    cd00162
    Location:837 → 869
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd16726
    Location:757 → 793
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    pfam06701
    Location:59 → 123
    MIB_HERC2; Mib_herc2
    pfam18346
    Location:227 → 291
    SH3_15; Mind bomb SH3 repeat domain
    cl17238
    Location:836 → 881
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  7. XM_030253882.1 → XP_030109742.1  E3 ubiquitin-protein ligase MIB2 isoform X5

    UniProtKB/Swiss-Prot
    A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
    UniProtKB/TrEMBL
    B2RUG2
    Conserved Domains (8) summary
    PLN03192
    Location:417 → 481
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:450 → 701
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:89 → 133
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:454 → 484
    ANK; ANK repeat [structural motif]
    cd16726
    Location:822 → 858
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    pfam06701
    Location:160 → 224
    MIB_HERC2; Mib_herc2
    pfam18346
    Location:292 → 356
    SH3_15; Mind bomb SH3 repeat domain
    cl17238
    Location:901 → 946
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  8. XM_036164530.1 → XP_036020423.1  E3 ubiquitin-protein ligase MIB2 isoform X4

    UniProtKB/Swiss-Prot
    A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
    Conserved Domains (9) summary
    PLN03192
    Location:424 → 488
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:457 → 708
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:89 → 133
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:461 → 491
    ANK; ANK repeat [structural motif]
    cd00162
    Location:909 → 941
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd16726
    Location:829 → 865
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    pfam06701
    Location:160 → 224
    MIB_HERC2; Mib_herc2
    pfam18346
    Location:324 → 388
    SH3_15; Mind bomb SH3 repeat domain
    cl17238
    Location:908 → 953
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  9. XM_036164529.1 → XP_036020422.1  E3 ubiquitin-protein ligase MIB2 isoform X3

    UniProtKB/Swiss-Prot
    A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
    Conserved Domains (9) summary
    PLN03192
    Location:428 → 492
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:461 → 712
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:89 → 133
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:465 → 495
    ANK; ANK repeat [structural motif]
    cd00162
    Location:913 → 945
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd16726
    Location:833 → 869
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    pfam06701
    Location:160 → 224
    MIB_HERC2; Mib_herc2
    pfam18346
    Location:328 → 392
    SH3_15; Mind bomb SH3 repeat domain
    cl17238
    Location:912 → 957
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  10. XM_030253879.1 → XP_030109739.1  E3 ubiquitin-protein ligase MIB2 isoform X1

    UniProtKB/Swiss-Prot
    A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
    Conserved Domains (9) summary
    PLN03192
    Location:453 → 517
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:486 → 737
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:89 → 133
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:490 → 520
    ANK; ANK repeat [structural motif]
    cd00162
    Location:938 → 970
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd16726
    Location:858 → 894
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    pfam06701
    Location:160 → 224
    MIB_HERC2; Mib_herc2
    pfam18346
    Location:328 → 392
    SH3_15; Mind bomb SH3 repeat domain
    cl17238
    Location:937 → 982
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  11. XM_006539251.4 → XP_006539314.1  E3 ubiquitin-protein ligase MIB2 isoform X1

    See identical proteins and their annotated locations for XP_006539314.1

    UniProtKB/Swiss-Prot
    A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
    Conserved Domains (9) summary
    PLN03192
    Location:453 → 517
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:486 → 737
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:89 → 133
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:490 → 520
    ANK; ANK repeat [structural motif]
    cd00162
    Location:938 → 970
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd16726
    Location:858 → 894
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    pfam06701
    Location:160 → 224
    MIB_HERC2; Mib_herc2
    pfam18346
    Location:328 → 392
    SH3_15; Mind bomb SH3 repeat domain
    cl17238
    Location:937 → 982
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  12. XM_006539254.3 → XP_006539317.1  E3 ubiquitin-protein ligase MIB2 isoform X1

    See identical proteins and their annotated locations for XP_006539317.1

    UniProtKB/Swiss-Prot
    A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
    Conserved Domains (9) summary
    PLN03192
    Location:453 → 517
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:486 → 737
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:89 → 133
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:490 → 520
    ANK; ANK repeat [structural motif]
    cd00162
    Location:938 → 970
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd16726
    Location:858 → 894
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    pfam06701
    Location:160 → 224
    MIB_HERC2; Mib_herc2
    pfam18346
    Location:328 → 392
    SH3_15; Mind bomb SH3 repeat domain
    cl17238
    Location:937 → 982
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  13. XM_006539249.4 → XP_006539312.1  E3 ubiquitin-protein ligase MIB2 isoform X1

    See identical proteins and their annotated locations for XP_006539312.1

    UniProtKB/Swiss-Prot
    A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
    Related
    ENSMUST00000151843.8
    Conserved Domains (9) summary
    PLN03192
    Location:453 → 517
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:486 → 737
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:89 → 133
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:490 → 520
    ANK; ANK repeat [structural motif]
    cd00162
    Location:938 → 970
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd16726
    Location:858 → 894
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    pfam06701
    Location:160 → 224
    MIB_HERC2; Mib_herc2
    pfam18346
    Location:328 → 392
    SH3_15; Mind bomb SH3 repeat domain
    cl17238
    Location:937 → 982
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  14. XM_011250353.2 → XP_011248655.1  E3 ubiquitin-protein ligase MIB2 isoform X10

    Conserved Domains (7) summary
    PLN03192
    Location:161 → 225
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:194 → 445
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:198 → 228
    ANK; ANK repeat [structural motif]
    cd00162
    Location:646 → 678
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    cd16726
    Location:566 → 602
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    pfam18346
    Location:36 → 100
    SH3_15; Mind bomb SH3 repeat domain
    cl17238
    Location:645 → 690
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  15. XM_017320437.1 → XP_017175926.1  E3 ubiquitin-protein ligase MIB2 isoform X8

    UniProtKB/Swiss-Prot
    A2A9P9, Q52QU8, Q6PEF6, Q8C1N7, Q8R516, Q8VIB4
    Conserved Domains (6) summary
    PLN03192
    Location:453 → 517
    PLN03192; Voltage-dependent potassium channel; Provisional
    PHA03095
    Location:486 → 737
    PHA03095; ankyrin-like protein; Provisional
    cd02339
    Location:89 → 133
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:490 → 520
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:160 → 224
    MIB_HERC2; Mib_herc2
    pfam18346
    Location:328 → 392
    SH3_15; Mind bomb SH3 repeat domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001256110.1: Suppressed sequence

    Description
    NM_001256110.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R516.2 GenPept UniProtKB/Swiss-Prot:Q8R516

Gene LinkOut

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