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Upp2 uridine phosphorylase 2 [ Mus musculus (house mouse) ]

Gene ID: 76654, updated on 5-Mar-2024

Summary

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Official Symbol
Upp2provided by MGI
Official Full Name
uridine phosphorylase 2provided by MGI
Primary source
MGI:MGI:1923904
See related
Ensembl:ENSMUSG00000026839 AllianceGenome:MGI:1923904
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UP2; UPASE2; UDRPASE2; 1700124F02Rik
Summary
Enables uridine phosphorylase activity. Involved in CMP catabolic process; UMP catabolic process; and uridine catabolic process. Located in cytosol. Is expressed in adrenal gland and gland. Orthologous to human UPP2 (uridine phosphorylase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 6.5), liver E18 (RPKM 2.0) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 C1.1; 2 33.16 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (58456329..58685858)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (58566317..58795846)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene activin A receptor, type IC Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3377 Neighboring gene predicted gene, 50616 Neighboring gene STARR-seq mESC enhancer starr_04543 Neighboring gene VISTA enhancer mm1599 Neighboring gene activin A receptor, type 1 Neighboring gene STARR-seq mESC enhancer starr_04549 Neighboring gene STARR-seq mESC enhancer starr_04550 Neighboring gene STARR-seq mESC enhancer starr_04553 Neighboring gene STARR-seq mESC enhancer starr_04555 Neighboring gene STARR-seq mESC enhancer starr_04557 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_04559 Neighboring gene coiled-coil domain containing 148 Neighboring gene STARR-seq mESC enhancer starr_04561 Neighboring gene STARR-positive B cell enhancer mm9_chr2:58998596-58998897 Neighboring gene predicted gene, 54155 Neighboring gene STARR-seq mESC enhancer starr_04563 Neighboring gene plakophilin 4 Neighboring gene STARR-seq mESC enhancer starr_04569

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors. Zhang Y, et al. Mol Endocrinol, 2004 Apr. PMID 14715930
  2. Identification of a novel human uridine phosphorylase. Johansson M. Biochem Biophys Res Commun, 2003 Jul 18. PMID 12849978
  3. A novel structural mechanism for redox regulation of uridine phosphorylase 2 activity. Roosild TP, et al. J Struct Biol, 2011 Nov. PMID 21855639, Free PMC Article
  4. A wild derived quantitative trait locus on mouse chromosome 2 prevents obesity. Mollah MB, et al. BMC Genet, 2010 Sep 23. PMID 20860848, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of BMAL1-Regulated circadian genes in mouse liver and their potential association with hepatocellular carcinoma: Gys2 and Upp2 as promising candidates.
    Title: Identification of BMAL1-Regulated circadian genes in mouse liver and their potential association with hepatocellular carcinoma: Gys2 and Upp2 as promising candidates.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables deoxyuridine phosphorylase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables pentosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables uridine phosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables uridine phosphorylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables uridine phosphorylase activity ISO
Inferred from Sequence Orthology
more info
  
enables uridine phosphorylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in CMP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in UMP catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dCMP catabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in nucleoside metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in uridine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in uridine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in uridine catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in type III intermediate filament ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
uridine phosphorylase 2
Names
L-UrdPase
liver-specific uridine phosphorylase
NP_001276588.1
NP_001276589.1
NP_083968.1
XP_006498469.1
XP_006498470.1
XP_006498472.1
XP_006498473.1
XP_011237507.1
XP_011237508.1
XP_011237509.1
XP_017174811.1
XP_030108053.1
XP_036018568.1
XP_036018569.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289659.1 → NP_001276588.1  uridine phosphorylase 2 isoform 1

    See identical proteins and their annotated locations for NP_001276588.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK149444, AL844163, AW112009, BY133124
    Consensus CDS
    CCDS79797.1
    UniProtKB/TrEMBL
    A0A2R8VHC9, Q8R093
    Related
    ENSMUSP00000060437.7, ENSMUST00000059102.13
    Conserved Domains (1) summary
    cl00303
    Location:47 → 332
    PNP_UDP_1; Phosphorylase superfamily

  2. NM_001289660.1 → NP_001276589.1  uridine phosphorylase 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate 5' and 3' terminal exons, initiates translation at an alternate start codon and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes variant 2, which is shorter and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AK044005, AL844163, AW123722, CJ130127
    Consensus CDS
    CCDS71055.1
    UniProtKB/TrEMBL
    A2APN2, Q8BLN7
    Related
    ENSMUSP00000071474.6, ENSMUST00000071543.12
    Conserved Domains (1) summary
    cl00303
    Location:67 → 308
    PNP_UDP_1; Phosphorylase superfamily

  3. NM_029692.3 → NP_083968.1  uridine phosphorylase 2 isoform 3

    See identical proteins and their annotated locations for NP_083968.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 3, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AK149444, AL844163, AW112009, BY133124
    Consensus CDS
    CCDS16051.1
    UniProtKB/Swiss-Prot
    Q8CGR7
    UniProtKB/TrEMBL
    A0A2R8VHC9, Q3UEN1
    Related
    ENSMUSP00000099816.4, ENSMUST00000102755.4
    Conserved Domains (1) summary
    cd17763
    Location:37 → 311
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    58456329..58685858
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498407.5 → XP_006498470.1  uridine phosphorylase 2 isoform X4

    UniProtKB/TrEMBL
    Q8BLN7
    Conserved Domains (1) summary
    cd17763
    Location:75 → 349
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

  2. XM_036162676.1 → XP_036018569.1  uridine phosphorylase 2 isoform X5

    UniProtKB/Swiss-Prot
    Q8CGR7
    UniProtKB/TrEMBL
    A0A2R8VHC9, Q3UEN1
    Conserved Domains (1) summary
    cd17763
    Location:37 → 311
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

  3. XM_006498406.4 → XP_006498469.1  uridine phosphorylase 2 isoform X3

    See identical proteins and their annotated locations for XP_006498469.1

    UniProtKB/TrEMBL
    Q8BLN7
    Conserved Domains (1) summary
    cd17763
    Location:91 → 365
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

  4. XM_017319322.3 → XP_017174811.1  uridine phosphorylase 2 isoform X6

    Conserved Domains (1) summary
    cl00303
    Location:158 → 189
    PNP_UDP_1; Phosphorylase superfamily

  5. XM_030252193.1 → XP_030108053.1  uridine phosphorylase 2 isoform X5

    UniProtKB/Swiss-Prot
    Q8CGR7
    UniProtKB/TrEMBL
    A0A2R8VHC9, Q3UEN1
    Conserved Domains (1) summary
    cd17763
    Location:37 → 311
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

  6. XM_011239207.2 → XP_011237509.1  uridine phosphorylase 2 isoform X3

    See identical proteins and their annotated locations for XP_011237509.1

    UniProtKB/TrEMBL
    Q8BLN7
    Conserved Domains (1) summary
    cd17763
    Location:91 → 365
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

  7. XM_011239205.3 → XP_011237507.1  uridine phosphorylase 2 isoform X1

    Conserved Domains (1) summary
    cd17763
    Location:166 → 399
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

  8. XM_011239206.4 → XP_011237508.1  uridine phosphorylase 2 isoform X2

    Conserved Domains (1) summary
    cd17763
    Location:166 → 399
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

  9. XM_036162675.1 → XP_036018568.1  uridine phosphorylase 2 isoform X5

    UniProtKB/Swiss-Prot
    Q8CGR7
    UniProtKB/TrEMBL
    A0A2R8VHC9, Q3UEN1
    Conserved Domains (1) summary
    cd17763
    Location:37 → 311
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

  10. XM_006498409.4 → XP_006498472.1  uridine phosphorylase 2 isoform X5

    See identical proteins and their annotated locations for XP_006498472.1

    UniProtKB/Swiss-Prot
    Q8CGR7
    UniProtKB/TrEMBL
    A0A2R8VHC9, Q3UEN1
    Conserved Domains (1) summary
    cd17763
    Location:37 → 311
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

  11. XM_006498410.5 → XP_006498473.1  uridine phosphorylase 2 isoform X5

    See identical proteins and their annotated locations for XP_006498473.1

    UniProtKB/Swiss-Prot
    Q8CGR7
    UniProtKB/TrEMBL
    A0A2R8VHC9, Q3UEN1
    Conserved Domains (1) summary
    cd17763
    Location:37 → 311
    UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

RNA

  1. XR_003953741.1 RNA Sequence

  2. XR_003953739.1 RNA Sequence

  3. XR_003953740.2 RNA Sequence

  4. XR_866022.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CGR7.1 GenPept UniProtKB/Swiss-Prot:Q8CGR7

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