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Usp42 ubiquitin specific peptidase 42 [ Mus musculus (house mouse) ]

Gene ID: 76800, updated on 7-May-2024

Summary

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Official Symbol
Usp42provided by MGI
Official Full Name
ubiquitin specific peptidase 42provided by MGI
Primary source
MGI:MGI:1924050
See related
Ensembl:ENSMUSG00000051306 AllianceGenome:MGI:1924050
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D5Ertd591e; 2410140K03Rik; 3110031A07Rik; A630018G05Rik
Summary
Enables thiol-dependent deubiquitinase. Involved in protein deubiquitination. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; eye; lung; testis; and thymus. Orthologous to human USP42 (ubiquitin specific peptidase 42). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 13.7), CNS E11.5 (RPKM 4.9) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Usp42 in Genome Data Viewer
Location:
5 G2; 5 82.5 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (143696077..143741600, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (143710325..143759753, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54311 Neighboring gene cytohesin 3 Neighboring gene predicted gene, 38737 Neighboring gene RIKEN cDNA D130017N08 gene Neighboring gene STARR-positive B cell enhancer ABC_E10364 Neighboring gene STARR-positive B cell enhancer ABC_E2182 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 1 Neighboring gene ankyrin repeat domain 61

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The expression of Usp42 during embryogenesis and spermatogenesis in mouse. Kim YK, et al. Gene Expr Patterns, 2007 Jan. PMID 16904385
  2. Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Pettitt SJ, et al. Nat Methods, 2009 Jul. PMID 19525957, Free PMC Article
  3. Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Adissu HA, et al. Dis Model Mech, 2014 May. PMID 24652767, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 42
Names
deubiquitinating enzyme 42
ubiquitin specific protease 42
ubiquitin thioesterase 42
ubiquitin thiolesterase 42
ubiquitin-specific-processing protease 42
NP_084025.2
XP_006504817.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029749.2 → NP_084025.2  ubiquitin carboxyl-terminal hydrolase 42

    See identical proteins and their annotated locations for NP_084025.2

    Status: VALIDATED

    Source sequence(s)
    AC136746
    Consensus CDS
    CCDS39372.1
    UniProtKB/Swiss-Prot
    B2RQC2
    Related
    ENSMUSP00000053955.6, ENSMUST00000053287.6
    Conserved Domains (3) summary
    cd02661
    Location:109 → 409
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam05642
    Location:723 → 870
    Sporozoite_P67; Sporozoite P67 surface antigen
    pfam05109
    Location:420 → 795
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    143696077..143741600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504754.5 → XP_006504817.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X1

    See identical proteins and their annotated locations for XP_006504817.1

    UniProtKB/Swiss-Prot
    B2RQC2
    Conserved Domains (3) summary
    cd02661
    Location:109 → 409
    Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam05642
    Location:723 → 870
    Sporozoite_P67; Sporozoite P67 surface antigen
    pfam05109
    Location:420 → 795
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RQC2.1 GenPept UniProtKB/Swiss-Prot:B2RQC2

Gene LinkOut

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