Mboat7 membrane bound O-acyltransferase domain containing 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mboat7provided by MGI
Official Full Name: membrane bound O-acyltransferase domain containing 7provided by MGI
Primary source: MGI:MGI:1924832
See related: Ensembl:ENSMUSG00000035596 AllianceGenome:MGI:1924832
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BB1; Leng4; Lpiat; Lpiat1; LPLAT 7; m-mboa-7; 5730589L02Rik
Summary: Enables O-acyltransferase activity and lysophospholipid acyltransferase activity. Involved in phosphatidylinositol acyl-chain remodeling and regulation of triglyceride metabolic process. Acts upstream of or within layer formation in cerebral cortex; phosphatidylinositol metabolic process; and ventricular system development. Located in membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and respiratory system. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human MBOAT7 (membrane bound O-acyltransferase domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 41.2), ovary adult (RPKM 26.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 2.12 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (3680788..3696188, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (3677789..3693189, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury.
Title: Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury.
LPGAT1/LPLAT7 regulates acyl chain profiles at the sn-1 position of phospholipids in murine skeletal muscles.
Title: LPGAT1/LPLAT7 regulates acyl chain profiles at the sn-1 position of phospholipids in murine skeletal muscles.
MBOAT7-driven lysophosphatidylinositol acylation in adipocytes contributes to systemic glucose homeostasis.
Title: MBOAT7-driven lysophosphatidylinositol acylation in adipocytes contributes to systemic glucose homeostasis.
Loss of hepatic Mboat7 leads to liver fibrosis.
Title: Loss of hepatic Mboat7 leads to liver fibrosis.
The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer.
Title: The ACSL3-LPIAT1 signaling drives prostaglandin synthesis in non-small cell lung cancer.
LPIAT1-deficient RAW264.7 cells showed prolonged oscillations of intracellular calcium.
Title: Lysophosphatidylinositol-acyltransferase-1 is involved in cytosolic Ca(2+) oscillations in macrophages.
These results suggest that LPEAT1/MBOAT1 plays an important role in neurite outgrowth and function.
Title: Lysophosphatidylethanolamine acyltransferase 1/membrane-bound O-acyltransferase 1 regulates morphology and function of P19C6 cell-derived neurons.
LPIAT1 has an essential role in maintaining physiological levels of PtdIns and PtdInsP(2) in the mouse
Title: Lysophosphatidylinositol-acyltransferase-1 (LPIAT1) is required to maintain physiological levels of PtdIns and PtdInsP(2) in the mouse.
Data show that lysophosphatidylinositol acyltransferase 1 (LPIAT1, also known as MBOAT7) plays a crucial role in brain development in mice.
Title: LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice.
Congenital hydrocephalus in Mboat 7 null mice
Title: Congenital hydrocephalus in genetically engineered mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH139374 (e-PCR)
- UniSTS:221460

NoName (e-PCR)
- UniSTS:235587

BF404995 (e-PCR)
- UniSTS:247171

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables O-acyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables lysophospholipid acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophospholipid acyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within layer formation in cerebral cortex	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylcholine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol acyl-chain remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphatidylinositol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondria-associated endoplasmic reticulum membrane contact site	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondria-associated endoplasmic reticulum membrane contact site	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysophospholipid acyltransferase 7

Names: 1-acylglycerophosphatidylinositol O-acyltransferase; bladder and breast carcinoma-overexpressed gene 1 protein; leukocyte receptor cluster (LRC) member 4; lysophosphatidylinositol acyltransferase 1; membrane-bound O-acyltransferase domain-containing protein 7

NP_084210.2

EC 2.3.1.n4

XP_006540495.1

EC 2.3.1.n4

XP_006540496.1

EC 2.3.1.n4

XP_011249044.1

EC 2.3.1.n4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.