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HPP1 hyperpigmentation, progressive, 1 [ Homo sapiens (human) ]

Gene ID: 780897, updated on 2-Oct-2019

Summary

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Gene symbol
HPP1
Gene description
hyperpigmentation, progressive, 1
Primary source
MIM:145250
Gene type
unknown
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPP; MUH; FPH1

Genomic context

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Location:
19pter-p13.1

Bibliography

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Related articles in PubMed

  1. Methylated free-circulating HPP1 DNA is an early response marker in patients with metastatic colorectal cancer. Herbst A, et al. Int J Cancer, 2017 May 1. PMID 28124380
  2. The Tumor Suppressive Effects of HPP1 Are Mediated Through JAK-STAT-Interferon Signaling Pathways. Hernandez JM, et al. DNA Cell Biol, 2015 Aug. PMID 26061044, Free PMC Article
  3. Linkage of a locus determining familial progressive hyperpigmentation (FPH) to chromosome 19p13.1-pter in a Chinese family. Zhang C, et al. Eur J Dermatol, 2006 May-Jun. PMID 16709486
  4. Circulating cell-free methylated DNA and lactate dehydrogenase release in colorectal cancer. Philipp AB, et al. BMC Cancer, 2014 Apr 8. PMID 24708595, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Detection of HPP1 mfcDNA can be used as a prognostic marker and an early marker for response (as early as 3-4 weeks after start of treatment compared with radiological staging after 12 or 24 weeks) to identify patients who will likely benefit from a combination chemotherapy with bevacizumab
    Title: Methylated free-circulating HPP1 DNA is an early response marker in patients with metastatic colorectal cancer.
  2. HPP1 tumor suppressive effects are mediated through JAK-STAT-Interferon pathways.
    Title: The Tumor Suppressive Effects of HPP1 Are Mediated Through JAK-STAT-Interferon Signaling Pathways.
  3. We were able to provide evidence that methylation of HLTF and especially HPP1 detected in serum is strongly correlated with cell death in CRC using LDH as surrogate marker
    Title: Circulating cell-free methylated DNA and lactate dehydrogenase release in colorectal cancer.
Submit: New GeneRIF Correction

Phenotypes

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hyperpigmentation, progressive, 1

General gene information

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Other Names

  • familial progressive hyperpigmentation 1

Property

  • phenotype only

Gene LinkOut

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Molecular Biology Databases