Cst11 cystatin 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cst11provided by MGI
Official Full Name: cystatin 11provided by MGI
Primary source: MGI:MGI:1925490
See related: Ensembl:ENSMUSG00000036958 AllianceGenome:MGI:1925490
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CRES2; mCSTE1; 9230101F08Rik
Summary: Predicted to enable cysteine-type endopeptidase inhibitor activity. Predicted to be involved in defense response to Gram-negative bacterium and killing of cells of other organism. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular region. Predicted to be active in several cellular components, including nucleus; sperm flagellum; and sperm head. Is expressed in epididymis. Orthologous to human CST11 (cystatin 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward genital fat pad adult (RPKM 228.3) See more
Orthologs: human all
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Genomic context

Location:: 2 G3; 2 73.54 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (148610538..148613417, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (148768618..148771497, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identification and characterization; investigated the tissue distribution and localization of the corresponding mRNA and examined its regulation in the epididymis by testosterone and/or 17ss-estradiol
Title: Cystatin E1 and E2, new members of male reproductive tract subgroup within cystatin type 2 family.
CRES2 and CRES3 represent new members of a subgroup of cystatin family 2 proteins that likely carry out tissue-specific functions distinct from that of typical cystatins CRES2, CRES3]
Title: Cres2 and Cres3: new members of the cystatin-related epididymal spermatogenic subgroup of family 2 cystatins.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB067629 (e-PCR)
- UniSTS:185504

NoName (e-PCR)
- UniSTS:485298

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in killing of cells of another organism	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in sperm flagellum	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info
is_active_in sperm head	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm head	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cystatin-11

Names: cystatin E1; cystatin-related epididymal spermatogenic protein 2; mCST E1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.