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Ndor1 NADPH dependent diflavin oxidoreductase 1 [ Mus musculus (house mouse) ]

Gene ID: 78797, updated on 4-Jun-2024

Summary

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Official Symbol
Ndor1provided by MGI
Official Full Name
NADPH dependent diflavin oxidoreductase 1provided by MGI
Primary source
MGI:MGI:1926047
See related
Ensembl:ENSMUSG00000006471 Ensembl:ENSMUSG00000115074 AllianceGenome:MGI:1926047
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NR1; Ndor; Ubc-cre; 4930447P04Rik; Tg(UBC-cre/ERT2)1Ejb
Summary
Predicted to enable several functions, including NADPH-hemoprotein reductase activity; nucleotide binding activity; and oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor. Predicted to be involved in cell death; cellular response to menadione; and electron transport chain. Predicted to be located in cytoplasm; intermediate filament cytoskeleton; and nucleoplasm. Predicted to be active in cytosol. Orthologous to human NDOR1 (NADPH dependent diflavin oxidoreductase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 16.6), spleen adult (RPKM 13.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ndor1 in Genome Data Viewer
Location:
2 A3; 2 17.1 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25134825..25145458, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25244813..25255509, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cysteine rich tail 1 Neighboring gene ring finger protein 208 Neighboring gene transmembrane protein 203 Neighboring gene STARR-positive B cell enhancer ABC_E805 Neighboring gene taperin Neighboring gene SS nuclear autoantigen 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Multicolor fate mapping of Langerhans cell homeostasis. Ghigo C, et al. J Exp Med, 2013 Aug 26. PMID 23940255, Free PMC Article
  2. Generation of a tamoxifen inducible SMN mouse for temporal SMN replacement. Bebee TW, et al. Genesis, 2011 Dec. PMID 21538807
  3. Allelic contribution of Nrxn1α to autism-relevant behavioral phenotypes in mice. Xu B, et al. PLoS Genet, 2023 Feb. PMID 36848371, Free PMC Article
  4. Evidence of shared transcriptomic dysregulation of HNRNPU-related disorder between human organoids and embryonic mice. Ressler AK, et al. iScience, 2023 Jan 20. PMID 36594023, Free PMC Article
  5. The nuclear factor of activated T cells 5 (NFAT5) contributes to the renal corticomedullary differences in gene expression. Chernyakov D, et al. Sci Rep, 2022 Nov 24. PMID 36433977, Free PMC Article

See all (472) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FAD binding ISO
Inferred from Sequence Orthology
more info
  
enables FMN binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables FMN binding ISO
Inferred from Sequence Orthology
more info
  
enables NADP binding ISO
Inferred from Sequence Orthology
more info
  
enables NADPH binding ISO
Inferred from Sequence Orthology
more info
  
enables NADPH-hemoprotein reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables electron transfer activity ISO
Inferred from Sequence Orthology
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in electron transport chain ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NADPH-dependent diflavin oxidoreductase 1
Names
NADPH-dependent FMN and FAD-containing oxidoreductase
Tg(UBC-cre)1Ejb
Tg(UBC-cre/ESR1)1Ejb
NP_001075945.1
NP_001239470.1
NP_001239471.1
XP_006498504.1
XP_006498505.1
XP_006498506.1
XP_006498507.1
XP_006498508.1
XP_006498509.1
XP_006498510.1
XP_006498511.1
XP_006498513.1
XP_006498514.1
XP_006498515.1
XP_006498518.1
XP_030108111.1
XP_030108112.1
XP_030108113.1
XP_036018619.1
XP_036018620.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082476.2 → NP_001075945.1  NADPH-dependent diflavin oxidoreductase 1 isoform 1

    See identical proteins and their annotated locations for NP_001075945.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AK019617, AL732309
    Consensus CDS
    CCDS38069.1
    UniProtKB/Swiss-Prot
    A2AI05, Q3TQZ6, Q80WC5
    Related
    ENSMUSP00000109989.3, ENSMUST00000114349.9
    Conserved Domains (3) summary
    COG0369
    Location:6 → 597
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    pfam00258
    Location:8 → 145
    Flavodoxin_1; Flavodoxin
    cl06868
    Location:212 → 597
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

  2. NM_001252541.1 → NP_001239470.1  NADPH-dependent diflavin oxidoreductase 1 isoform 2

    See identical proteins and their annotated locations for NP_001239470.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK163207, AL732309
    Consensus CDS
    CCDS57157.1
    UniProtKB/Swiss-Prot
    A2AI05
    Related
    ENSMUSP00000097903.4, ENSMUST00000100329.10
    Conserved Domains (3) summary
    COG0369
    Location:6 → 530
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    pfam00258
    Location:8 → 123
    Flavodoxin_1; Flavodoxin
    cl06868
    Location:145 → 530
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

  3. NM_001252542.1 → NP_001239471.1  NADPH-dependent diflavin oxidoreductase 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTRs and has multiple differences in the coding region, one of which results in a translational frameshift, compared to variant 1. The encoded isoform (3) is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK143124, AL732309
    Consensus CDS
    CCDS89442.1
    UniProtKB/TrEMBL
    A0A2I3BQN1
    Related
    ENSMUSP00000154261.2, ENSMUST00000228052.2
    Conserved Domains (3) summary
    COG0369
    Location:1 → 450
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    pfam00258
    Location:1 → 76
    Flavodoxin_1; Flavodoxin
    cl06868
    Location:143 → 450
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    25134825..25145458 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498446.5 → XP_006498509.1  NADPH-dependent diflavin oxidoreductase 1 isoform X5

    Conserved Domains (1) summary
    COG0369
    Location:6 → 519
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

  2. XM_036162726.1 → XP_036018619.1  NADPH-dependent diflavin oxidoreductase 1 isoform X11

    Conserved Domains (1) summary
    COG0369
    Location:6 → 551
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

  3. XM_006498455.5 → XP_006498518.1  NADPH-dependent diflavin oxidoreductase 1 isoform X14

    Conserved Domains (1) summary
    COG0369
    Location:98 → 570
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

  4. XM_006498441.5 → XP_006498504.1  NADPH-dependent diflavin oxidoreductase 1 isoform X1

    Conserved Domains (1) summary
    COG0369
    Location:98 → 570
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

  5. XM_006498451.5 → XP_006498514.1  NADPH-dependent diflavin oxidoreductase 1 isoform X8

    See identical proteins and their annotated locations for XP_006498514.1

    Conserved Domains (1) summary
    COG0369
    Location:98 → 570
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

  6. XM_006498450.5 → XP_006498513.1  NADPH-dependent diflavin oxidoreductase 1 isoform X8

    See identical proteins and their annotated locations for XP_006498513.1

    Conserved Domains (1) summary
    COG0369
    Location:98 → 570
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

  7. XM_006498447.5 → XP_006498510.1  NADPH-dependent diflavin oxidoreductase 1 isoform X6

    Conserved Domains (1) summary
    COG0369
    Location:98 → 602
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

  8. XM_006498445.5 → XP_006498508.1  NADPH-dependent diflavin oxidoreductase 1 isoform X4

    See identical proteins and their annotated locations for XP_006498508.1

    Conserved Domains (1) summary
    COG0369
    Location:98 → 602
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

  9. XM_006498444.5 → XP_006498507.1  NADPH-dependent diflavin oxidoreductase 1 isoform X4

    See identical proteins and their annotated locations for XP_006498507.1

    Conserved Domains (1) summary
    COG0369
    Location:98 → 602
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

  10. XM_006498452.4 → XP_006498515.1  NADPH-dependent diflavin oxidoreductase 1 isoform X10

    Conserved Domains (2) summary
    pfam00258
    Location:1 → 76
    Flavodoxin_1
    cl06868
    Location:143 → 450
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

  11. XM_030252252.2 → XP_030108112.1  NADPH-dependent diflavin oxidoreductase 1 isoform X13

    Conserved Domains (1) summary
    cl06868
    Location:59 → 366
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

  12. XM_006498448.5 → XP_006498511.1  NADPH-dependent diflavin oxidoreductase 1 isoform X7

    Conserved Domains (1) summary
    COG0369
    Location:25 → 497
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

  13. XM_030252253.2 → XP_030108113.1  NADPH-dependent diflavin oxidoreductase 1 isoform X13

    Conserved Domains (1) summary
    cl06868
    Location:59 → 366
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

  14. XM_006498442.5 → XP_006498505.1  NADPH-dependent diflavin oxidoreductase 1 isoform X2

    Conserved Domains (1) summary
    COG0369
    Location:98 → 570
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

  15. XM_036162727.1 → XP_036018620.1  NADPH-dependent diflavin oxidoreductase 1 isoform X12

    Conserved Domains (2) summary
    pfam00258
    Location:1 → 76
    Flavodoxin_1
    cl06868
    Location:143 → 528
    FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

  16. XM_006498443.5 → XP_006498506.1  NADPH-dependent diflavin oxidoreductase 1 isoform X3

    Conserved Domains (1) summary
    COG0369
    Location:98 → 648
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

  17. XM_030252251.2 → XP_030108111.1  NADPH-dependent diflavin oxidoreductase 1 isoform X9

    Conserved Domains (1) summary
    COG0369
    Location:25 → 575
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

RNA

  1. XR_004940781.1 RNA Sequence

  2. XR_004940780.1 RNA Sequence

  3. XR_004940779.1 RNA Sequence

  4. XR_004940778.1 RNA Sequence

  5. XR_004940777.1 RNA Sequence

  6. XR_374139.5 RNA Sequence

  7. XR_374138.5 RNA Sequence

  8. XR_003953749.2 RNA Sequence

  9. XR_866029.4 RNA Sequence

  10. XR_866028.4 RNA Sequence

  11. XR_374141.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178239.2: Suppressed sequence

    Description
    NM_178239.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AI05.1 GenPept UniProtKB/Swiss-Prot:A2AI05

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