Cnot10 CCR4-NOT transcription complex, subunit 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cnot10provided by MGI
Official Full Name: CCR4-NOT transcription complex, subunit 10provided by MGI
Primary source: MGI:MGI:1926143
See related: Ensembl:ENSMUSG00000056167 AllianceGenome:MGI:1926143
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2600001P13Rik
Summary: Predicted to be involved in mRNA catabolic process and negative regulation of translation. Predicted to act upstream of or within gene silencing by RNA and regulation of translation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of CCR4-NOT complex. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and white fat. Orthologous to human CNOT10 (CCR4-NOT transcription complex subunit 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in limb E14.5 (RPKM 25.5), CNS E11.5 (RPKM 22.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F3; 9 64.72 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (114414942..114469289, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (114585874..114640220, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNF219 interacts with CCR4-NOT in regulating stem cell differentiation.
Title: RNF219 interacts with CCR4-NOT in regulating stem cell differentiation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in mRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CCR4-NOT complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CCR4-NOT complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CCR4-NOT transcription complex subunit 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153585.5 → NP_705813.2 CCR4-NOT transcription complex subunit 10

See identical proteins and their annotated locations for NP_705813.2

Status: VALIDATED

Source sequence(s)

AK029103, CA537067, CX222096

Consensus CDS

CCDS40794.1

UniProtKB/Swiss-Prot

Q05CH8, Q3TSS4, Q3UDS5, Q80VN2, Q8BH15, Q8CI74

Related

ENSMUSP00000064840.7, ENSMUST00000070117.8

Conserved Domains (2) summary

COG0457
Location:59 → 274

TPR; Tetratricopeptide (TPR) repeat [General function prediction only]

sd00006
Location:296 → 321

TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

114414942..114469289 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155411.1 → XP_036011304.1 CCR4-NOT transcription complex subunit 10 isoform X4

Conserved Domains (1) summary

sd00006
Location:296 → 321

TPR; TPR repeat [structural motif]
XM_030244727.2 → XP_030100587.1 CCR4-NOT transcription complex subunit 10 isoform X3

Conserved Domains (1) summary

sd00006
Location:296 → 321

TPR; TPR repeat [structural motif]
XM_006512399.4 → XP_006512462.1 CCR4-NOT transcription complex subunit 10 isoform X1

See identical proteins and their annotated locations for XP_006512462.1

UniProtKB/Swiss-Prot

Q8BH15

Conserved Domains (1) summary

sd00006
Location:296 → 321

TPR; TPR repeat [structural motif]
XM_017313699.2 → XP_017169188.1 CCR4-NOT transcription complex subunit 10 isoform X2

Conserved Domains (1) summary

sd00006
Location:296 → 321

TPR; TPR repeat [structural motif]