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Akr1a1 aldo-keto reductase family 1 member A1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 78959, updated on 2-May-2024

Summary

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Official Symbol
Akr1a1provided by RGD
Official Full Name
aldo-keto reductase family 1 member A1provided by RGD
Primary source
RGD:68346
See related
Ensembl:ENSRNOG00000016727 AllianceGenome:RGD:68346
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Akr1a4
Summary
Enables L-glucuronate reductase activity and glucuronolactone reductase activity. Involved in D-glucuronate catabolic process; L-ascorbic acid biosynthetic process; and cellular detoxification of aldehyde. Predicted to be located in apical plasma membrane. Predicted to be active in cytosol and synapse. Orthologous to human AKR1A1 (aldo-keto reductase family 1 member A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 5068.0), Adrenal (RPKM 1749.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Akr1a1 in Genome Data Viewer
Location:
5q35
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (135329605..135367037, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (130092945..130130277, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (135482068..135498693, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 17 Neighboring gene nuclear autoantigenic sperm protein Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134486971 Neighboring gene peroxiredoxin 1 Neighboring gene metabolism of cobalamin associated C Neighboring gene coiled-coil domain containing 163

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Author Correction: Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury. Zhou HL, et al. Nature, 2019 Jun. PMID 31089212
  2. Identification of a novel glycolysis-related gene signature that can predict the survival of patients with lung adenocarcinoma. Liu C, et al. Cell Cycle, 2019 Mar. PMID 30727821, Free PMC Article
  3. Reductive detoxification of acrolein as a potential role for aldehyde reductase (AKR1A) in mammals. Kurahashi T, et al. Biochem Biophys Res Commun, 2014 Sep 12. PMID 25152401
  4. Identity of a major 3-deoxyglucosone-reducing enzyme with aldehyde reductase in rat liver established by amino acid sequencing and cDNA expression. Takahashi M, et al. Gene, 1993 May 30. PMID 8500767
  5. The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients. Hlaváč V, et al. Medicine (Baltimore), 2014 Dec. PMID 25526449, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-glucuronate reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-glucuronate reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables S-nitrosoglutathione reductase (NADH) activity ISO
Inferred from Sequence Orthology
more info
  
enables S-nitrosoglutathione reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables alcohol dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables aldose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldose reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables all-trans-retinol dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables all-trans-retinol dehydrogenase (NAD+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables allyl-alcohol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucuronolactone reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glucuronolactone reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycerol dehydrogenase [NADP+] activity IEA
Inferred from Electronic Annotation
more info
  
enables methylglyoxal reductase (NADPH) (acetol producing) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in D-glucuronate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within D-glucuronate catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in L-ascorbic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within L-ascorbic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in L-ascorbic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in aldehyde catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within aldehyde catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular detoxification of aldehyde IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular detoxification of aldehyde ISO
Inferred from Sequence Orthology
more info
  
involved_in daunorubicin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in doxorubicin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glucuronate catabolic process to xylulose 5-phosphate ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
aldo-keto reductase family 1 member A1
Names
3-DG-reducing enzyme
alcohol dehydrogenase
aldehyde reductase
glucuronate reductase
glucuronolactone reductase
NP_112262.1
XP_038966744.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031000.3 → NP_112262.1  aldo-keto reductase family 1 member A1

    See identical proteins and their annotated locations for NP_112262.1

    Status: PROVISIONAL

    Source sequence(s)
    D10854
    UniProtKB/Swiss-Prot
    P51635
    UniProtKB/TrEMBL
    A0A8I6AVC9, A6JZ88
    Related
    ENSRNOP00000023072.3, ENSRNOT00000023072.6
    Conserved Domains (1) summary
    cd19106
    Location:8 → 312
    AKR_AKR1A1-4; AKR1A family of aldo-keto reductase (AKR)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    135329605..135367037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110816.2 → XP_038966744.1  aldo-keto reductase family 1 member A1 isoform X1

    UniProtKB/Swiss-Prot
    P51635
    UniProtKB/TrEMBL
    A0A8I6AVC9, A6JZ88
    Related
    ENSRNOP00000092196.1
    Conserved Domains (1) summary
    cd19106
    Location:8 → 312
    AKR_AKR1A1-4; AKR1A family of aldo-keto reductase (AKR)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51635.2 GenPept UniProtKB/Swiss-Prot:P51635

Gene LinkOut

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