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ZNF426 zinc finger protein 426 [ Homo sapiens (human) ]

Gene ID: 79088, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF426provided by HGNC
Official Full Name
zinc finger protein 426provided by HGNC
Primary source
HGNC:HGNC:20725
See related
Ensembl:ENSG00000130818 AllianceGenome:HGNC:20725
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K-RBP
Summary
Kaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in esophagus (RPKM 5.6), ovary (RPKM 2.9) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
19p13.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (9523223..9538645, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (9649415..9664832, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9633899..9649321, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372269 Neighboring gene zinc finger protein 560 Neighboring gene uncharacterized LOC105372268 Neighboring gene actin beta pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:9648627-9649362 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13931 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:9650343-9651542 Neighboring gene ZNF426 divergent transcript Neighboring gene NANOG hESC enhancer GRCh37_chr19:9677059-9677560 Neighboring gene zinc finger protein 121 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:9692318-9693131 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:9693132-9693944 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:9694759-9695570

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The zinc finger DNA-binding domain of K-RBP plays an important role in regulating Kaposi's sarcoma-associated herpesvirus RTA-mediated gene expression. Yang Z, et al. Virology, 2009 Sep 1. PMID 19592062, Free PMC Article
  2. Kaposi's sarcoma-associated herpesvirus transactivator RTA promotes degradation of the repressors to regulate viral lytic replication. Yang Z, et al. J Virol, 2008 Apr. PMID 18216089, Free PMC Article
  3. The transcriptional repressor K-RBP modulates RTA-mediated transactivation and lytic replication of Kaposi's sarcoma-associated herpesvirus. Yang Z, et al. J Virol, 2007 Jun. PMID 17409159, Free PMC Article
  4. Identification of a cellular protein that interacts and synergizes with the RTA (ORF50) protein of Kaposi's sarcoma-associated herpesvirus in transcriptional activation. Wang S, et al. J Virol, 2001 Dec. PMID 11711586, Free PMC Article
  5. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. Chen Y, et al. Mol Cell Proteomics, 2013 Oct. PMID 23824909, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings suggest that the DNA-binding activity of K-RBP plays an important role in repressing viral promoter activity.
    Title: The zinc finger DNA-binding domain of K-RBP plays an important role in regulating Kaposi's sarcoma-associated herpesvirus RTA-mediated gene expression.
  2. It was found that herpesvirus 8 RTA can induce K-RBP degradation through the ubiquitin-proteasome pathway and that two regions in RTA are responsible.
    Title: Kaposi's sarcoma-associated herpesvirus transactivator RTA promotes degradation of the repressors to regulate viral lytic replication.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC2663

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 426
Names
CTC-543D15.7
KSHV RTA binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300883.3 → NP_001287812.1  zinc finger protein 426 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AB209837, AC008567, BP245135
    Consensus CDS
    CCDS74279.1
    UniProtKB/TrEMBL
    K7ER43
    Related
    ENSP00000468100.1, ENST00000593003.5
    Conserved Domains (6) summary
    smart00349
    Location:4 → 60
    KRAB; krueppel associated box
    COG5048
    Location:296 → 448
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:412 → 432
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:186 → 208
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:424 → 449
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001318055.2 → NP_001304984.1  zinc finger protein 426 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC008567, BC001791, BP245135
    UniProtKB/Swiss-Prot
    Q9BUY5
    Conserved Domains (4) summary
    COG5048
    Location:223 → 375
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:339 → 359
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:113 → 135
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:351 → 376
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001318056.2 → NP_001304985.1  zinc finger protein 426 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 3' coding region compared to variant 1, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC008567, BC001791, BE315219, BP245135
    Consensus CDS
    CCDS82285.1
    UniProtKB/TrEMBL
    K7EME3
    Related
    ENSP00000466469.1, ENST00000589289.1
    Conserved Domains (1) summary
    smart00349
    Location:42 → 98
    KRAB; krueppel associated box

  4. NM_024106.3 → NP_077011.1  zinc finger protein 426 isoform 1

    See identical proteins and their annotated locations for NP_077011.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC008567, BC001791, BP245135
    Consensus CDS
    CCDS12215.1
    UniProtKB/Swiss-Prot
    B3KTL2, Q9BUY5
    Related
    ENSP00000253115.1, ENST00000253115.7
    Conserved Domains (5) summary
    smart00349
    Location:42 → 98
    KRAB; krueppel associated box
    COG5048
    Location:334 → 486
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:450 → 470
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:224 → 246
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:294 → 319
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    9523223..9538645 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    9649415..9664832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BUY5.1 GenPept UniProtKB/Swiss-Prot:Q9BUY5

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