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pde8a phosphodiesterase 8A [ Danio rerio (zebrafish) ]

Gene ID: 791145, updated on 27-Mar-2024

Summary

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Official Symbol
pde8aprovided by ZNC
Official Full Name
phosphodiesterase 8Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070112-622
See related
Ensembl:ENSDARG00000087941 AllianceGenome:ZFIN:ZDB-GENE-070112-622
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:158458
Summary
Predicted to enable 3',5'-cyclic-nucleotide phosphodiesterase activity and metal ion binding activity. Predicted to be involved in cAMP catabolic process. Predicted to act upstream of or within phosphorelay signal transduction system and regulation of transcription, DNA-templated. Orthologous to human PDE8A (phosphodiesterase 8A). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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Location:
chromosome: 18
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (16378..33817, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (16378..33817, complement)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene homer scaffold protein 2 Neighboring gene WAS protein homolog associated with actin, golgi membranes and microtubules Neighboring gene fibronectin type III and SPRY domain containing 2 Neighboring gene glycine amidinotransferase (L-arginine:glycine amidinotransferase) Neighboring gene zgc:158482

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
NP_001074096.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080627.1 → NP_001074096.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

    See identical proteins and their annotated locations for NP_001074096.1

    Status: PROVISIONAL

    Source sequence(s)
    BC129238
    UniProtKB/TrEMBL
    A1L1W3
    Related
    ENSDARP00000107237.3, ENSDART00000129125.3
    Conserved Domains (5) summary
    COG0745
    Location:67 → 158
    OmpR; DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription]
    cd00130
    Location:215 → 311
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    cd00156
    Location:68 → 155
    REC; Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; ...
    pfam00233
    Location:541 → 792
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:211 → 307
    PAS_9; PAS domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    16378..33817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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