Dck deoxycytidine kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dckprovided by RGD
Official Full Name: deoxycytidine kinaseprovided by RGD
Primary source: RGD:620667
See related: Ensembl:ENSRNOG00000003296 AllianceGenome:RGD:620667
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including ATP binding activity; deoxycytidine kinase activity; and magnesium ion binding activity. Involved in deoxycytidine metabolic process and nucleotide phosphorylation. Located in cytosol. Orthologous to human DCK (deoxycytidine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 541.5), Spleen (RPKM 193.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (19589298..19610326, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (19305218..19326247, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (20935442..20952939, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A cytosolic form of TK2 was identified in all tested tissues in addition to mitochondrial TK2. TK1 was detected in liver and spleen cytosolic extracts while dCK was found in liver, spleen and lung cytosolic extracts.
Title: Tissue specific distribution of pyrimidine deoxynucleoside salvage enzymes shed light on the mechanism of mitochondrial DNA depletion.

Submit: New GeneRIF Correction

General gene information

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Markers

AI176044 (e-PCR)
- UniSTS:260613

GDB:437189 (e-PCR)
- UniSTS:157241

AI231703 (e-PCR)
- UniSTS:260963

RH141381 (e-PCR)
- UniSTS:223377

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cytidine kinase activity	IEA Inferred from Electronic Annotation more info
enables cytidine kinase activity	ISO Inferred from Sequence Orthology more info
enables deoxyadenosine kinase activity	IEA Inferred from Electronic Annotation more info
enables deoxyadenosine kinase activity	ISO Inferred from Sequence Orthology more info
enables deoxycytidine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deoxycytidine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables deoxycytidine kinase activity	IEA Inferred from Electronic Annotation more info
enables deoxycytidine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables deoxycytidine kinase activity	ISO Inferred from Sequence Orthology more info
enables deoxyguanosine kinase activity	IEA Inferred from Electronic Annotation more info
enables deoxyguanosine kinase activity	ISO Inferred from Sequence Orthology more info
enables deoxyribonucleoside binding	IPI Inferred from Physical Interaction more info	PubMed
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables pyrimidine deoxyribonucleoside binding	IDA Inferred from Direct Assay more info	PubMed
enables pyrimidine deoxyribonucleoside binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in CMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in dAMP salvage	IEA Inferred from Electronic Annotation more info
involved_in dAMP salvage	ISO Inferred from Sequence Orthology more info
involved_in deoxycytidine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in deoxycytidine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleoside phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine nucleotide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine nucleotide metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: deoxycytidine kinase

Names: deoxyadenosine kinase; deoxyguanosine kinase

NP_077072.2

EC 2.7.1.113

EC 2.7.1.74

EC 2.7.1.76

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024158.2 → NP_077072.2 deoxycytidine kinase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

P48769

UniProtKB/TrEMBL

A6KKI1, G3V6E9

Related

ENSRNOP00000004440.5, ENSRNOT00000004440.8

Conserved Domains (1) summary

pfam01712
Location:24 → 258

dNK; Deoxynucleoside kinase