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Dnajc5 DnaJ heat shock protein family (Hsp40) member C5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 79130, updated on 30-Mar-2024

Summary

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Official Symbol
Dnajc5provided by RGD
Official Full Name
DnaJ heat shock protein family (Hsp40) member C5provided by RGD
Primary source
RGD:620516
See related
Ensembl:ENSRNOG00000015202 AllianceGenome:RGD:620516
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Csp
Summary
Enables ATP-dependent protein binding activity. Predicted to be involved in chaperone-mediated protein folding and regulation of synaptic vesicle cycle. Predicted to act upstream of or within negative regulation of neuron apoptotic process. Located in terminal bouton. Is anchored component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 4B. Orthologous to human DNAJC5 (DnaJ heat shock protein family (Hsp40) member C5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 594.8), Thymus (RPKM 269.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q43
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (188999508..189033455)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168621905..168656570)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (177012714..177047787)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548047 Neighboring gene abhydrolase domain containing 16B Neighboring gene TPD52 like 2 Neighboring gene ribosomal protein L34-like2 Neighboring gene uridine-cytidine kinase 1-like 1 Neighboring gene zinc finger protein 512B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phosphomimetic mutation of cysteine string protein-α increases the rate of regulated exocytosis by modulating fusion pore dynamics in PC12 cells. Chiang N, et al. PLoS One, 2014. PMID 24956274, Free PMC Article
  2. Characterization of cysteine string protein in rat parotid acinar cells. Shimomura H, et al. Arch Biochem Biophys, 2013 Oct 1. PMID 23942053
  3. Functional role of J domain of cysteine string protein in Ca2+-dependent secretion from acinar cells. Weng N, et al. Am J Physiol Gastrointest Liver Physiol, 2009 May. PMID 19282376, Free PMC Article
  4. The CSPalpha/G protein complex in PC12 cells. Bai L, et al. Biochem Biophys Res Commun, 2007 Jan 5. PMID 17113038
  5. Phosphorylation of cysteine string protein in the brain: developmental, regional and synaptic specificity. Evans GJ, et al. Eur J Neurosci, 2005 May. PMID 15926915

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CSPalpha may modulate fusion pore dynamics in a phosphorylation-dependent manner.
    Title: Phosphomimetic mutation of cysteine string protein-α increases the rate of regulated exocytosis by modulating fusion pore dynamics in PC12 cells.
  2. both the J-domain and the linker domain of CSP1 are necessary to function in an important role in acinar cell exocytosis
    Title: Characterization of cysteine string protein in rat parotid acinar cells.
  3. a biochemical link between Hsp40 expression and Abeta(42) proteostasis that is cell specific
    Title: Cell line specific modulation of extracellular aβ42 by Hsp40.
  4. Establish a role for CSP-alpha in regulating digestive enzyme secretion and suggest that CSP-alpha and Hsc70 modulate specific soluble N-ethylmaleimide-sensitive attachment receptor interactions necessary for exocytosis.
    Title: Functional role of J domain of cysteine string protein in Ca2+-dependent secretion from acinar cells.
  5. palmitoylation of CSP is enhanced specifically by co-expression of the Golgi-localized palmitoyl transferases DHHC3, DHHC7, DHHC15, or DHHC17
    Title: Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein.
  6. CSPalpha activity is subject to regulation by factors that alter Hsc70 distribution and translocation within the cell
    Title: The CSPalpha/G protein complex in PC12 cells.
  7. cysteine string protein binds to a brain-specific isoform of small glutamine-rich tetratricopeptide repeat-containing protein
    Title: A brain-specific isoform of small glutamine-rich tetratricopeptide repeat-containing protein binds to Hsc70 and the cysteine string protein.
  8. phosphorylation-dependent interaction with synaptotagmin I
    Title: Phosphorylation-dependent interaction of the synaptic vesicle proteins cysteine string protein and synaptotagmin I.
  9. A novel alphaGDI complex from synaptic membranes contains three chaperone components: Hsp90, Hsc70 and cysteine string protein (CSP). The complex is dissociated in response to Ca(2+)-induced neurotransmitter release.
    Title: Rab-alphaGDI activity is regulated by a Hsp90 chaperone complex.
  10. Proportion of the phosphorylated protein varies between distinct brain regions and also exhibits developmental regulation.
    Title: Phosphorylation of cysteine string protein in the brain: developmental, regional and synaptic specificity.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP-dependent protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chaperone-mediated protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chaperone-mediated protein folding ISO
Inferred from Sequence Orthology
more info
  
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic vesicle cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synaptic vesicle cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in chromaffin granule membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in melanosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in presynapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in terminal bouton HDA PubMed 

General protein information

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Preferred Names
dnaJ homolog subfamily C member 5
Names
DnaJ (Hsp40) homolog, subfamily C, member 5
cysteine string protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024161.3 → NP_077075.1  dnaJ homolog subfamily C member 5

    See identical proteins and their annotated locations for NP_077075.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    P60905
    UniProtKB/TrEMBL
    A0A8I6A9F3, A6KLZ8
    Conserved Domains (1) summary
    COG0484
    Location:15 → 84
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    188999508..189033455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008762544.4 → XP_008760766.1  dnaJ homolog subfamily C member 5 isoform X1

    See identical proteins and their annotated locations for XP_008760766.1

    UniProtKB/Swiss-Prot
    P60905
    UniProtKB/TrEMBL
    A0A8I6A9F3, A6KLZ8
    Conserved Domains (1) summary
    COG0484
    Location:15 → 84
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

  2. XM_008762545.4 → XP_008760767.1  dnaJ homolog subfamily C member 5 isoform X1

    See identical proteins and their annotated locations for XP_008760767.1

    UniProtKB/Swiss-Prot
    P60905
    UniProtKB/TrEMBL
    A0A8I6A9F3, A6KLZ8
    Related
    ENSRNOP00000020581.1
    Conserved Domains (1) summary
    COG0484
    Location:15 → 84
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

RNA

  1. XR_352967.5 RNA Sequence

  2. XR_352968.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P60905.1 GenPept UniProtKB/Swiss-Prot:P60905

Gene LinkOut

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