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Gabrg3 gamma-aminobutyric acid type A receptor subunit gamma 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 79211, updated on 2-May-2024

Summary

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Official Symbol
Gabrg3provided by RGD
Official Full Name
gamma-aminobutyric acid type A receptor subunit gamma 3provided by RGD
Primary source
RGD:621735
See related
Ensembl:ENSRNOG00000014862 AllianceGenome:RGD:621735
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables GABA-A receptor activity and chloride channel activity. Involved in response to xenobiotic stimulus. Predicted to be located in postsynaptic membrane. Predicted to be part of GABA-A receptor complex. Predicted to be active in GABA-ergic synapse; dendrite membrane; and postsynapse. Predicted to be integral component of synaptic membrane. Orthologous to human GABRG3 (gamma-aminobutyric acid type A receptor subunit gamma3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 41.2) See more
Orthologs
human mouse all
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Genomic context

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See Gabrg3 in Genome Data Viewer
Location:
1q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (116763332..117386770, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (107627450..108247483, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (112158525..112812267, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene DNA methyltransferase 3 alpha, pseudogene 3 Neighboring gene OCA2 melanosomal transmembrane protein Neighboring gene DNA polymerase epsilon 3, accessory subunit, pseudogene 1 Neighboring gene ribosomal protein L6, pseudogene 17 Neighboring gene inactive serine/threonine-protein kinase VRK3-like Neighboring gene uncharacterized LOC120099822 Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha 5 Neighboring gene SAP domain containing ribonucleoprotein, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The gamma 3-subunit of the GABAA-receptor confers sensitivity to benzodiazepine receptor ligands. Knoflach F, et al. FEBS Lett, 1991 Nov 18. PMID 1660002
  2. The third gamma subunit of the gamma-aminobutyric acid type A receptor family. Herb A, et al. Proc Natl Acad Sci U S A, 1992 Feb 15. PMID 1311098, Free PMC Article
  3. Antagonism of fenfluramine-induced hyperthermia: a measure of central serotonin inhibition. Sulpizio A, et al. Life Sci, 1978 Apr 24. PMID 27681
  4. Postsynaptic clustering of gamma-aminobutyric acid type A receptors by the gamma3 subunit in vivo. Baer K, et al. Proc Natl Acad Sci U S A, 1999 Oct 26. PMID 10536013, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GABA-A receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GABA-A receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables GABA-gated chloride ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GABA-gated chloride ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to benzodiazepine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
  
involved_in gamma-aminobutyric acid signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gamma-aminobutyric acid signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in gamma-aminobutyric acid signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in inhibitory synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic transmission, GABAergic IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of GABA-A receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendrite membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
  
part_of transmembrane transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
gamma-aminobutyric acid receptor subunit gamma-3
Names
GABA(A) receptor subunit gamma-3
GABA-alpha receptor gamma-3 subunit
gamma-aminobutyric acid (GABA) A receptor, gamma 3
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3
gamma-aminobutyric acid A receptor, gamma 3
gamma-aminobutyric acid type A receptor gamma 3 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024370.3 → NP_077346.3  gamma-aminobutyric acid receptor subunit gamma-3 precursor

    See identical proteins and their annotated locations for NP_077346.3

    Status: VALIDATED

    Source sequence(s)
    M81142, X63324
    UniProtKB/Swiss-Prot
    P28473
    UniProtKB/TrEMBL
    A0A0A0MXX6, A6KD36
    Related
    ENSRNOP00000076184.1, ENSRNOT00000093339.2
    Conserved Domains (3) summary
    TIGR00860
    Location:50 → 464
    LIC; Cation transporter family protein
    pfam02931
    Location:48 → 253
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:260 → 461
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    116763332..117386770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017589765.3 → XP_017445254.1  gamma-aminobutyric acid receptor subunit gamma-3 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28473.1 GenPept UniProtKB/Swiss-Prot:P28473

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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