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selp selectin P [ Danio rerio (zebrafish) ]

Gene ID: 796481, updated on 27-Mar-2024

Summary

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Official Symbol
selpprovided by ZNC
Official Full Name
selectin Pprovided by ZNC
Primary source
ZFIN:ZDB-GENE-110107-2
See related
Ensembl:ENSDARG00000042138 AllianceGenome:ZFIN:ZDB-GENE-110107-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-260g14.4
Summary
Predicted to enable oligosaccharide binding activity and sialic acid binding activity. Acts upstream of or within hematopoietic stem cell migration to bone marrow and hemopoiesis. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in head; trunk; and vascular cord. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; atopic dermatitis; cerebrovascular disease (multiple); and coronary artery disease (multiple). Orthologous to several human genes including SELP (selectin P). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 20
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (33948640..33961697, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (34045761..34058818, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene retinoid X receptor, gamma b Neighboring gene LIM homeobox transcription factor 1, alpha Neighboring gene si:dkey-51e6.1 Neighboring gene selectin E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular cloning and expression analysis of P-selectin from Zebrafish (Danio rerio). Sun G, et al. Int J Mol Sci, 2010 Nov 17. PMID 21151460, Free PMC Article
  2. Exogenous melatonin inhibits neutrophil migration through suppression of ERK activation. Ren DL, et al. J Endocrinol, 2015 Oct. PMID 26303298
  3. Testicular transcriptome alterations in zebrafish (Danio rerio) exposure to 17β-estradiol. Zheng Y, et al. Chemosphere, 2019 Mar. PMID 30465971
  4. Molecular insights into 4-nitrophenol-induced hepatotoxicity in zebrafish: transcriptomic, histological and targeted gene expression analyses. Lam SH, et al. Biochim Biophys Acta, 2013 Oct. PMID 23791553
  5. Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via Prostaglandin E2 and P-Selectin Activity. Esain V, et al. Stem Cells, 2015 Aug. PMID 25931248, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via Prostaglandin E2 and P-Selectin Activity.
    Title: Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via Prostaglandin E2 and P-Selectin Activity.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oligosaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sialic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hematopoietic stem cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hematopoietic stem cell migration to bone marrow IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in leukocyte tethering or rolling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to cytokine IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
P-selectin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243323.1 → NP_001230252.1  P-selectin

    See identical proteins and their annotated locations for NP_001230252.1

    Status: PROVISIONAL

    Source sequence(s)
    GU566727
    UniProtKB/TrEMBL
    A0A8M9P2S1, E5DV48, F1Q625
    Related
    ENSDARP00000061764.4, ENSDART00000061765.5
    Conserved Domains (4) summary
    cd00033
    Location:751 → 806
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03592
    Location:26 → 144
    CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
    cd00054
    Location:153 → 178
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cl27761
    Location:324 → 489
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    33948640..33961697 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021468527.1 → XP_021324202.1  P-selectin isoform X1

    UniProtKB/TrEMBL
    A0A8M9P2S1, E5DV48, F1Q625
    Related
    ENSDARP00000115465.1, ENSDART00000133081.3
    Conserved Domains (4) summary
    cd00033
    Location:751 → 806
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd03592
    Location:26 → 144
    CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
    cd00054
    Location:153 → 178
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cl27761
    Location:324 → 489
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
Nucleotide Protein Strain
Heading Accession and Version

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