U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ATF7IP2 activating transcription factor 7 interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 80063, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
ATF7IP2provided by HGNC
Official Full Name
activating transcription factor 7 interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:20397
See related
Ensembl:ENSG00000166669 MIM:613645; AllianceGenome:HGNC:20397
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCAF2
Summary
Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 6.9), lymph node (RPKM 2.0) and 24 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
16p13.2-p13.13
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (10386061..10483638)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (10421735..10519259)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (10479918..10577495)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371078 Neighboring gene VISTA enhancer hs1242 Neighboring gene RNA, 7SL, cytoplasmic 493, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10377 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10378 Neighboring gene MPRA-validated peak2497 silencer Neighboring gene CRISPRi-validated cis-regulatory element chr16.1137 Neighboring gene Sharpr-MPRA regulatory region 5183 Neighboring gene MPRA-validated peak2499 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10379 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7191 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7192 Neighboring gene uncharacterized LOC107984877 Neighboring gene CRISPRi-validated cis-regulatory element chr16.1145 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:10597803-10598610 Neighboring gene RNA, U6 small nuclear 633, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10380 Neighboring gene long intergenic non-protein coding RNA 1290

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins. Ichimura T, et al. J Biol Chem, 2005 Apr 8. PMID 15691849
  2. Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. Adkins DE, et al. Mol Psychiatry, 2011 Mar. PMID 20195266, Free PMC Article
  3. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Yao Z, et al. Mol Cell, 2017 Jan 19. PMID 28065597, Free PMC Article
  4. Proteome-scale mapping of binding sites in the unstructured regions of the human proteome. Benz C, et al. Mol Syst Biol, 2022 Jan. PMID 35044719, Free PMC Article
  5. RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation. Wu SF, et al. Proc Natl Acad Sci U S A, 2020 Jun 23. PMID 32513696, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ12668

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA methylation-dependent heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
activating transcription factor 7-interacting protein 2
Names
ATF7-interacting protein 2
MBD1-containing chromatin associated factor 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256160.3 → NP_001243089.1  activating transcription factor 7-interacting protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001243089.1

    Status: VALIDATED

    Source sequence(s)
    AC131649, AK093414, AL832987, BC144468
    Consensus CDS
    CCDS58422.1
    UniProtKB/Swiss-Prot
    Q5U623
    Related
    ENSP00000379807.1, ENST00000396559.5
    Conserved Domains (1) summary
    pfam16788
    Location:291 → 496
    ATF7IP_BD; ATF-interacting protein binding domain

  2. NM_001352120.2 → NP_001339049.1  activating transcription factor 7-interacting protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131649
    Consensus CDS
    CCDS10540.1
    UniProtKB/Swiss-Prot
    B2RNR2, Q53EZ7, Q5U623, Q658U2, Q6IS97, Q8N9X8, Q9H9L6
    Conserved Domains (2) summary
    pfam16788
    Location:292 → 496
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:574 → 673
    fn3_4; Fibronectin-III type domain

  3. NM_001393719.1 → NP_001380648.1  activating transcription factor 7-interacting protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131649
    Consensus CDS
    CCDS10540.1
    UniProtKB/Swiss-Prot
    B2RNR2, Q53EZ7, Q5U623, Q658U2, Q6IS97, Q8N9X8, Q9H9L6
    Related
    ENSP00000457731.2, ENST00000562102.6
    Conserved Domains (2) summary
    pfam16788
    Location:292 → 496
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:574 → 673
    fn3_4; Fibronectin-III type domain

  4. NM_024997.5 → NP_079273.2  activating transcription factor 7-interacting protein 2 isoform 1

    See identical proteins and their annotated locations for NP_079273.2

    Status: VALIDATED

    Source sequence(s)
    AC131649, AL832987, BC033891, BC137079
    Consensus CDS
    CCDS10540.1
    UniProtKB/Swiss-Prot
    B2RNR2, Q53EZ7, Q5U623, Q658U2, Q6IS97, Q8N9X8, Q9H9L6
    Related
    ENSP00000379808.2, ENST00000396560.6
    Conserved Domains (2) summary
    pfam16788
    Location:292 → 496
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:574 → 673
    fn3_4; Fibronectin-III type domain

RNA

  1. NR_045815.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC131649
    Related
    ENST00000568027.5

  2. NR_045816.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC131649, AK299040, AL832987, BC144468

  3. NR_147927.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC131649

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    10386061..10483638
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434683.1 → XP_047290639.1  activating transcription factor 7-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RNR2, Q53EZ7, Q5U623, Q658U2, Q6IS97, Q8N9X8, Q9H9L6

  2. XM_047434684.1 → XP_047290640.1  activating transcription factor 7-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B2RNR2, Q53EZ7, Q5U623, Q658U2, Q6IS97, Q8N9X8, Q9H9L6

  3. XM_017023707.3 → XP_016879196.1  activating transcription factor 7-interacting protein 2 isoform X3

    UniProtKB/TrEMBL
    H3BPC9
    Related
    ENSP00000440791.1, ENST00000535850.5

  4. XM_006720954.5 → XP_006721017.1  activating transcription factor 7-interacting protein 2 isoform X5

    UniProtKB/TrEMBL
    H3BPC9
    Conserved Domains (1) summary
    pfam16788
    Location:291 → 366
    ATF7IP_BD; ATF-interacting protein binding domain

  5. XM_006720953.4 → XP_006721016.1  activating transcription factor 7-interacting protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006721016.1

    UniProtKB/Swiss-Prot
    B2RNR2, Q53EZ7, Q5U623, Q658U2, Q6IS97, Q8N9X8, Q9H9L6
    Related
    ENSP00000348799.2, ENST00000356427.2
    Conserved Domains (2) summary
    pfam16788
    Location:292 → 496
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:574 → 673
    fn3_4; Fibronectin-III type domain

  6. XM_047434685.1 → XP_047290641.1  activating transcription factor 7-interacting protein 2 isoform X2

    Related
    ENSP00000322811.5, ENST00000324570.9

  7. XM_017023708.2 → XP_016879197.1  activating transcription factor 7-interacting protein 2 isoform X4

  8. XM_011522666.3 → XP_011520968.1  activating transcription factor 7-interacting protein 2 isoform X6

    Conserved Domains (2) summary
    pfam16788
    Location:7 → 108
    ATF7IP_BD; ATF-interacting protein binding domain
    pfam16794
    Location:186 → 285
    fn3_4; Fibronectin-III type domain

RNA

  1. XR_007064920.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    10421735..10519259
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313990.1 → XP_054169965.1  activating transcription factor 7-interacting protein 2 isoform X1

  2. XM_054313991.1 → XP_054169966.1  activating transcription factor 7-interacting protein 2 isoform X1

  3. XM_054313994.1 → XP_054169969.1  activating transcription factor 7-interacting protein 2 isoform X3

  4. XM_054313996.1 → XP_054169971.1  activating transcription factor 7-interacting protein 2 isoform X5

  5. XM_054313992.1 → XP_054169967.1  activating transcription factor 7-interacting protein 2 isoform X1

  6. XM_054313993.1 → XP_054169968.1  activating transcription factor 7-interacting protein 2 isoform X2

  7. XM_054313995.1 → XP_054169970.1  activating transcription factor 7-interacting protein 2 isoform X4

  8. XM_054313997.1 → XP_054169972.1  activating transcription factor 7-interacting protein 2 isoform X6

RNA

  1. XR_008484739.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U623.2 GenPept UniProtKB/Swiss-Prot:Q5U623

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous