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Cubn cubilin [ Rattus norvegicus (Norway rat) ]

Gene ID: 80848, updated on 9-Dec-2024

Summary

Official Symbol
Cubnprovided by RGD
Official Full Name
cubilinprovided by RGD
Primary source
RGD:68355
See related
EnsemblRapid:ENSRNOG00000029047 AllianceGenome:RGD:68355
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
IFCR; MGA1; GP280
Summary
Enables cargo receptor activity; hemoglobin binding activity; and identical protein binding activity. Involved in several processes, including cobalamin catabolic process; cobalamin transport; and endocytic hemoglobin import into cell. Located in several cellular components, including brush border membrane; cytoplasmic vesicle; and lysosomal lumen. Part of receptor complex. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human CUBN (cubilin). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward (RPKM 1569.8) See more
Orthologs
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Genomic context

See Cubn in Genome Data Viewer
Location:
17q12.3
Exon count:
67
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (81293619..81501694, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (76385046..76593133, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (80584921..80807181, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482609 Neighboring gene Ras suppressor protein 1 Neighboring gene uncharacterized LOC134482610 Neighboring gene uncharacterized LOC102550536 Neighboring gene tRNA aspartic acid methyltransferase 1 Neighboring gene vimentin

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding  
enables cargo receptor activity  
enables cargo receptor activity PubMed 
enables cargo receptor activity  
enables cobalamin binding  
enables hemoglobin binding PubMed 
enables identical protein binding PubMed 
enables protein binding PubMed 
enables protein homodimerization activity  
enables protein homodimerization activity  
Process Evidence Code Pubs
involved_in cholesterol metabolic process  
involved_in cobalamin catabolic process PubMed 
involved_in cobalamin metabolic process  
involved_in cobalamin metabolic process  
involved_in cobalamin transport  
involved_in cobalamin transport PubMed 
involved_in cobalamin transport  
involved_in endocytic hemoglobin import into cell PubMed 
involved_in establishment of localization in cell  
acts_upstream_of_or_within establishment of localization in cell  
involved_in in utero embryonic development PubMed 
involved_in lipoprotein transport  
acts_upstream_of_or_within lipoprotein transport  
involved_in receptor-mediated endocytosis PubMed 
involved_in receptor-mediated endocytosis  
involved_in receptor-mediated endocytosis PubMed 
acts_upstream_of_or_within receptor-mediated endocytosis  
involved_in response to bacterium  
acts_upstream_of_or_within response to bacterium  
involved_in response to nutrient PubMed 
Items 1 - 20 of 35
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in Golgi apparatus  
located_in Golgi-associated vesicle PubMed 
located_in apical part of cell  
located_in apical plasma membrane PubMed 
located_in apical plasma membrane  
located_in apical plasma membrane  
located_in brush border  
located_in brush border  
located_in brush border membrane PubMed 
located_in clathrin-coated pit PubMed 
located_in clathrin-coated pit  
located_in clathrin-coated pit  
located_in coated vesicle PubMed 
located_in cytoplasm  
located_in endocytic vesicle  
located_in endocytic vesicle  
located_in endocytic vesicle membrane PubMed 
located_in endoplasmic reticulum  
located_in endoplasmic reticulum  
located_in endosome  
located_in endosome  
located_in endosome membrane  
located_in extracellular exosome  
located_in extracellular exosome  
located_in lysosomal lumen PubMed 
located_in lysosomal membrane  
located_in membrane  
located_in microvillus membrane  
is_active_in microvillus membrane  
is_active_in plasma membrane  
part_of protein-containing complex PubMed 
part_of receptor complex PubMed 
part_of receptor complex  
part_of receptor complex  
Items 1 - 20 of 35

General protein information

Preferred Names
cubilin
Names
460 kDa receptor
glycoprotein 280
intrinsic factor-cobalamin receptor
intrinsic factor-vitamin B12 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053332.4 → NP_445784.3  cubilin precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A0G2K9R4, A6JM40
    Related
    ENSRNOP00000075097.2, ENSRNOT00000090064.3
    Conserved Domains (6) summary
    smart00179
    Location:260 → 301
    EGF_CA; Calcium-binding EGF-like domain
    cd00041
    Location:1620 → 1733
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00054
    Location:432 → 468
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00431
    Location:1048 → 1157
    CUB; CUB domain
    pfam12947
    Location:350 → 387
    EGF_3; EGF domain
    cd22201
    Location:38 → 132
    cubilin_NTD; N-terminal domain of cubilin and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    81293619..81501694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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