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Inpp4a inositol polyphosphate-4-phosphatase type I A [ Rattus norvegicus (Norway rat) ]

Gene ID: 80849, updated on 25-Apr-2024

Summary

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Official Symbol
Inpp4aprovided by RGD
Official Full Name
inositol polyphosphate-4-phosphatase type I Aprovided by RGD
Primary source
RGD:68386
See related
Ensembl:ENSRNOG00000017660 AllianceGenome:RGD:68386
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity. Predicted to be involved in dephosphorylation and phosphatidylinositol-3-phosphate biosynthetic process. Predicted to be located in nuclear membrane; nucleoplasm; and postsynaptic density. Predicted to be active in cytoplasm. Orthologous to human INPP4A (inositol polyphosphate-4-phosphatase type I A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 219.4), Thymus (RPKM 113.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Inpp4a in Genome Data Viewer
Location:
9q21
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (47024064..47142391)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (39528245..39650574)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (43889887..44006593)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene cyclic nucleotide gated channel subunit alpha 3 Neighboring gene CB1 cannabinoid receptor-interacting protein 1-like Neighboring gene cytochrome C oxidase assembly factor 5 Neighboring gene unc-50 inner nuclear membrane RNA binding protein Neighboring gene uncharacterized LOC120094669 Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Novel nuclear translocation of inositol polyphosphate 4-phosphatase is associated with cell cycle, proliferation and survival. Chaudhuri R, et al. Biochim Biophys Acta Mol Cell Res, 2018 Jul 30. PMID 30071275
  2. The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death. Sasaki J, et al. Nature, 2010 May 27. PMID 20463662
  3. The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase. Norris FA, et al. J Biol Chem, 1995 Jul 7. PMID 7608176
  4. Structural Analysis of Hippocampal Kinase Signal Transduction. McClatchy DB, et al. ACS Chem Neurosci, 2018 Dec 19. PMID 30053369, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables inositol-1,3,4-trisphosphate 4-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol-3,4-bisphosphate 4-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
inositol polyphosphate-4-phosphatase type I A
Names
inositol polyphosphate 4-phosphatase type I
inositol polyphosphate-4-phosphatase, type 1
inositol polyphosphate-4-phosphatase, type I, 107kD
type I inositol 3,4-bisphosphate 4-phosphatase
NP_112264.4
XP_038940152.1
XP_038940153.1
XP_038940154.1
XP_038940156.1
XP_038940157.1
XP_038940158.1
XP_038940161.1
XP_038940162.1
XP_038940164.1
XP_038940166.1
XP_038940168.1
XP_038940169.1
XP_063123836.1
XP_063123838.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031002.4 → NP_112264.4  inositol polyphosphate-4-phosphatase type I A

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q62784
    Related
    ENSRNOP00000083933.1, ENSRNOT00000110836.1
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    47024064..47142391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084233.2 → XP_038940161.1  inositol polyphosphate-4-phosphatase type I A isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZYR7, A0A8I6ACW4
    Related
    ENSRNOP00000085223.1
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  2. XM_063267766.1 → XP_063123836.1  inositol polyphosphate-4-phosphatase type I A isoform X7

  3. XM_039084241.2 → XP_038940169.1  inositol polyphosphate-4-phosphatase type I A isoform X12

    UniProtKB/TrEMBL
    A0A8I6A0Y3
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  4. XM_039084224.2 → XP_038940152.1  inositol polyphosphate-4-phosphatase type I A isoform X1

    UniProtKB/TrEMBL
    A0A8I6ACW4
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  5. XM_063267768.1 → XP_063123838.1  inositol polyphosphate-4-phosphatase type I A isoform X11

  6. XM_039084225.2 → XP_038940153.1  inositol polyphosphate-4-phosphatase type I A isoform X1

    UniProtKB/TrEMBL
    A0A8I6ACW4
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  7. XM_039084230.2 → XP_038940158.1  inositol polyphosphate-4-phosphatase type I A isoform X4

    UniProtKB/TrEMBL
    A0A8I6ACW4
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  8. XM_039084238.2 → XP_038940166.1  inositol polyphosphate-4-phosphatase type I A isoform X9

    UniProtKB/Swiss-Prot
    Q62784
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  9. XM_039084240.2 → XP_038940168.1  inositol polyphosphate-4-phosphatase type I A isoform X10

    UniProtKB/Swiss-Prot
    Q62784
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  10. XM_039084226.2 → XP_038940154.1  inositol polyphosphate-4-phosphatase type I A isoform X1

    UniProtKB/TrEMBL
    A0A8I6ACW4
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  11. XM_039084229.2 → XP_038940157.1  inositol polyphosphate-4-phosphatase type I A isoform X3

    UniProtKB/TrEMBL
    A0A8I6ACW4
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  12. XM_039084234.2 → XP_038940162.1  inositol polyphosphate-4-phosphatase type I A isoform X6

    UniProtKB/Swiss-Prot
    Q62784
    UniProtKB/TrEMBL
    D3ZBL5
    Related
    ENSRNOP00000024330.8
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  13. XM_039084236.2 → XP_038940164.1  inositol polyphosphate-4-phosphatase type I A isoform X8

    UniProtKB/TrEMBL
    A0A8I6A0Y3
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

  14. XM_039084228.2 → XP_038940156.1  inositol polyphosphate-4-phosphatase type I A isoform X2

    UniProtKB/TrEMBL
    A0A8I6ACW4
    Conserved Domains (1) summary
    cd04048
    Location:44 → 157
    C2A_Copine; C2 domain first repeat in Copine

RNA

  1. XR_005488970.2 RNA Sequence

  2. XR_005488971.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62784.1 GenPept UniProtKB/Swiss-Prot:Q62784

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