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Abo ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase [ Mus musculus (house mouse) ]

Gene ID: 80908, updated on 4-Jan-2025

Summary

Official Symbol
Aboprovided by MGI
Official Full Name
ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferaseprovided by MGI
Primary source
MGI:MGI:2135738
See related
Ensembl:ENSMUSG00000015787 AllianceGenome:MGI:2135738
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NAGAT
Summary
Enables fucosylgalactoside 3-alpha-galactosyltransferase activity and glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity. Involved in oligosaccharide biosynthetic process. Predicted to be located in Golgi cisterna membrane. Predicted to be active in Golgi apparatus; extracellular region; and vesicle. Is expressed in alimentary system; male reproductive gland or organ; and spleen. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; graft-versus-host disease; leukemia (multiple); lung disease (multiple); and severe acute respiratory syndrome. Orthologous to human ABO (ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in genital fat pad adult (RPKM 4.6), colon adult (RPKM 3.3) and 2 other tissues See more
Orthologs
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Genomic context

See Abo in Genome Data Viewer
Location:
2 A3; 2 19.06 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26732508..26754973, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26842496..26864995, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39773 Neighboring gene predicted gene, 39774 Neighboring gene STARR-seq mESC enhancer starr_03995 Neighboring gene STARR-seq mESC enhancer starr_03996 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:26758332-26758621 Neighboring gene surfeit gene 6 Neighboring gene mediator complex subunit 22

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in lipid glycosylation  
involved_in oligosaccharide biosynthetic process PubMed 
involved_in protein glycosylation  
Component Evidence Code Pubs
is_active_in Golgi apparatus  
is_active_in Golgi apparatus PubMed 
located_in Golgi cisterna membrane  
is_active_in extracellular region PubMed 
is_active_in vesicle  

General protein information

Preferred Names
histo-blood group ABO system transferase
Names
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase)
cis-AB transferase
fucosylglycoprotein 3-alpha-galactosyltransferase
fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase
glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase
glycoprotein-fucosylgalactoside alpha-galactosyltransferase
histo-blood group A transferase
histo-blood group B transferase
NP_001277373.1
NP_109643.3
XP_006498519.1
XP_006498521.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290444.2NP_001277373.1  histo-blood group ABO system transferase isoform b

    Status: VALIDATED

    Source sequence(s)
    AL773563
    UniProtKB/TrEMBL
    Z4YLB0
    Conserved Domains (1) summary
    cl11394
    Location:60287
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
  2. NM_030718.6NP_109643.3  histo-blood group ABO system transferase isoform a

    See identical proteins and their annotated locations for NP_109643.3

    Status: VALIDATED

    Source sequence(s)
    AL773563
    Consensus CDS
    CCDS15811.1
    UniProtKB/Swiss-Prot
    A2AL98, P38649, Q8BZH3, Q8BZQ6, Q9EQW2, Q9EQW3
    UniProtKB/TrEMBL
    Z4YLB0
    Related
    ENSMUSP00000099964.2, ENSMUST00000102900.2
    Conserved Domains (1) summary
    pfam03414
    Location:45332
    Glyco_transf_6; Glycosyltransferase family 6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    26732508..26754973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498456.4XP_006498519.1  histo-blood group ABO system transferase isoform X1

    UniProtKB/TrEMBL
    Z4YLB0
    Conserved Domains (1) summary
    cl11394
    Location:102389
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
  2. XM_006498458.4XP_006498521.1  histo-blood group ABO system transferase isoform X2

    Conserved Domains (1) summary
    cl11394
    Location:16246
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
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