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PF3D7_1023200 orotidine 5'-phosphate decarboxylase [ Plasmodium falciparum 3D7 ]

Gene ID: 810382, updated on 16-Oct-2023

Summary

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Gene symbol
PF3D7_1023200
Gene description
orotidine 5'-phosphate decarboxylase
Locus tag
PF3D7_1023200
Gene type
protein coding
RNA name
orotidine 5'-phosphate decarboxylase
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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Location:
chromosome: 10
Exon count:
1
Sequence:
Chromosome: 10; NC_037281.1 (982231..983202)

Chromosome 10 - NC_037281.1Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium membrane protein, unknown function Neighboring gene dynein heavy chain, putative Neighboring gene conserved protein, unknown function Neighboring gene HORMA domain protein, putative

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037281.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Re-refinement of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase provides a clearer picture of an important malarial drug target. Novak WRP, et al. Acta Crystallogr F Struct Biol Commun, 2018 Oct 1. PMID 30279319, Free PMC Article
  2. Structure and inhibition of orotidine 5'-monophosphate decarboxylase from Plasmodium falciparum. Langley DB, et al. Biochemistry, 2008 Mar 25. PMID 18303855
  3. A unique insertion of low complexity amino acid sequence underlies protein-protein interaction in human malaria parasite orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase. Imprasittichail W, et al. Asian Pac J Trop Med, 2014 Mar. PMID 24507637
  4. Kinetic benefits and thermal stability of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase enzyme complex in human malaria parasite Plasmodium falciparum. Kanchanaphum P, et al. Biochem Biophys Res Commun, 2009 Dec 11. PMID 19800871
  5. A novel enzyme complex of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase in human malaria parasite Plasmodium falciparum: physical association, kinetics, and inhibition characterization. Krungkrai SR, et al. Biochemistry, 2005 Feb 8. PMID 15683248

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Re-refinement of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase as an important antimalarial drug target has been reported.
    Title: Re-refinement of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase provides a clearer picture of an important malarial drug target.
  2. Studied the multienzyme complex formation of human malaria parasite Plasmodium falciparum (P. falciparum) orotate phosphoribosyltransferase (OPRT) and orotidine 5'-monophosphate decarboxylase (OMPDC).
    Title: A unique insertion of low complexity amino acid sequence underlies protein-protein interaction in human malaria parasite orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase.
  3. The result suggests that the OPRT-OMPDC enzyme complex might have kinetic benefits and thermal stability significantly different from the monofunctional enzyme.
    Title: Kinetic benefits and thermal stability of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase enzyme complex in human malaria parasite Plasmodium falciparum.
  4. The structure of PfODCase displays classic TIM-barrel fold characteristic of the enzyme. Both the phosphate-binding loop & the betaalpha5-loop have conformational flexibility, which may be associated with substrate capture & product release.
    Title: Structure and inhibition of orotidine 5'-monophosphate decarboxylase from Plasmodium falciparum.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables orotidine-5'-phosphate decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within 'de novo' pyrimidine nucleobase biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
orotidine 5'-phosphate decarboxylase
XP_001347509.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_037281.1 Reference assembly

    Range
    982231..983202
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001347473.1 → XP_001347509.1  orotidine 5'-phosphate decarboxylase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001347509.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A024V766, A0A024VK62, A0A024WI90, A0A024X6V7, A0A0L7KKV5, Q8IJH3, Q8T6J6, W4IFC0, W4J4X9, W7F0Y5, W7FY21, W7JM29, W7JXM3
    Conserved Domains (1) summary
    cd04725
    Location:90 → 309
    OMP_decarboxylase_like; Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
2F84_A.1
2Q8L_A.1

Gene LinkOut

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