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PF3D7_1138400 guanylyl cyclase [ Plasmodium falciparum 3D7 ]

Gene ID: 810941, updated on 23-Nov-2023

Summary

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Gene symbol
PF3D7_1138400
Gene description
guanylyl cyclase
Locus tag
PF3D7_1138400
Gene type
protein coding
RNA name
guanylyl cyclase
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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Location:
chromosome: 11
Exon count:
1
Sequence:
Chromosome: 11; NC_037282.1 (1501011..1513691, complement)

Chromosome 11 - NC_037282.1Genomic Context describing neighboring genes Neighboring gene conserved protein, unknown function Neighboring gene conserved Plasmodium membrane protein, unknown function Neighboring gene protein phosphatase 2C Neighboring gene beta-catenin-like protein 1, putative

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037282.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Plasmodium falciparum Guanylyl Cyclase-Alpha and the Activity of Its Appended P4-ATPase Domain Are Essential for cGMP Synthesis and Blood-Stage Egress. Nofal SD, et al. mBio, 2021 Jan 26. PMID 33500341, Free PMC Article
  2. Guanylyl cyclase activity associated with putative bifunctional integral membrane proteins in Plasmodium falciparum. Carucci DJ, et al. J Biol Chem, 2000 Jul 21. PMID 10747978
  3. Disruption of a Plasmodium falciparum cyclic nucleotide phosphodiesterase gene causes aberrant gametogenesis. Taylor CJ, et al. Mol Microbiol, 2008 Jul. PMID 18452584, Free PMC Article
  4. CDC50 Orthologues in Plasmodium falciparum Have Distinct Roles in Merozoite Egress and Trophozoite Maturation. Patel A, et al. mBio, 2022 Aug 30. PMID 35862778, Free PMC Article
  5. Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Nature, 2002 Oct 3. PMID 12368864, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Decreased GC activity in parasites had no significant effect on gametogenesis.
    Title: Disruption of a Plasmodium falciparum cyclic nucleotide phosphodiesterase gene causes aberrant gametogenesis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cGMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within exit from host cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
guanylyl cyclase
XP_001348065.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_037282.1 Reference assembly

    Range
    1501011..1513691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001348029.1 → XP_001348065.1  guanylyl cyclase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001348065.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q8IHY1, Q9N9H5
    UniProtKB/TrEMBL
    A0A2I0BZY6, W7JS88
    Conserved Domains (5) summary
    cd07302
    Location:3968 → 4150
    CHD; cyclase homology domain
    TIGR01652
    Location:1811 → 2313
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam13246
    Location:1611 → 1663
    Cation_ATPase; Cation transport ATPase (P-type)
    cl11967
    Location:3004 → 3316
    Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
    cl21460
    Location:83 → 441
    HAD_like; Haloacid Dehalogenase-like Hydrolases
Nucleotide Protein
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