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PF3D7_1229100 multidrug resistance-associated protein 2 [ Plasmodium falciparum 3D7 ]

Gene ID: 811334, updated on 23-Nov-2023

Summary

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Gene symbol
PF3D7_1229100
Gene description
multidrug resistance-associated protein 2
Locus tag
PF3D7_1229100
Gene type
protein coding
RNA name
multidrug resistance-associated protein 2
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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Location:
chromosome: 12
Exon count:
1
Sequence:
Chromosome: 12; NC_037284.1 (1192888..1199214, complement)

Chromosome 12 - NC_037284.1Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved Plasmodium membrane protein, unknown function Neighboring gene ncRNA Neighboring gene conserved Plasmodium protein, unknown function

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037284.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Plasmodium falciparum ATP-binding cassette transporter is essential for liver stage entry into schizogony. Goswami D, et al. iScience, 2022 May 20. PMID 35521513, Free PMC Article
  2. Structural polymorphism in the promoter of pfmrp2 confers Plasmodium falciparum tolerance to quinoline drugs. Mok S, et al. Mol Microbiol, 2014 Mar. PMID 24372851, Free PMC Article
  3. Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Nature, 2002 Oct 3. PMID 12368864, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by GeneDB

Process Evidence Code Pubs
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within schizogony IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
multidrug resistance-associated protein 2
XP_001350688.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_037284.1 Reference assembly

    Range
    1192888..1199214 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001350652.1 → XP_001350688.1  multidrug resistance-associated protein 2 [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001350688.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I0BYJ5, D5L5S7, Q8I5C7
    Conserved Domains (3) summary
    COG1132
    Location:1388 → 2084
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
    cl38913
    Location:386 → 582
    ABC_6TM_exporters; Six-transmembrane helical domain of the ATP-binding cassette transporters
    cl38936
    Location:758 → 903
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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