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PF3D7_0512700 orotate phosphoribosyltransferase [ Plasmodium falciparum 3D7 ]

Gene ID: 812941, updated on 16-Oct-2023

Summary

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Gene symbol
PF3D7_0512700
Gene description
orotate phosphoribosyltransferase
Locus tag
PF3D7_0512700
Gene type
protein coding
RNA name
orotate phosphoribosyltransferase
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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Location:
chromosome: 5
Exon count:
1
Sequence:
Chromosome: 5; NC_004326.2 (546734..547579, complement)

Chromosome 5 - NC_004326.2Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene ras-related protein Rab-1B Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene AKAP-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004326.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of Plasmodium falciparum orotate phosphoribosyltransferase with autologous inhibitory protein-protein interactions. Kumar S, et al. Acta Crystallogr F Struct Biol Commun, 2015 May. PMID 25945715, Free PMC Article
  2. A unique insertion of low complexity amino acid sequence underlies protein-protein interaction in human malaria parasite orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase. Imprasittichail W, et al. Asian Pac J Trop Med, 2014 Mar. PMID 24507637
  3. Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases. Zhang Y, et al. J Biol Chem, 2013 Nov 29. PMID 24158442, Free PMC Article
  4. Kinetic benefits and thermal stability of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase enzyme complex in human malaria parasite Plasmodium falciparum. Kanchanaphum P, et al. Biochem Biophys Res Commun, 2009 Dec 11. PMID 19800871
  5. A novel enzyme complex of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase in human malaria parasite Plasmodium falciparum: physical association, kinetics, and inhibition characterization. Krungkrai SR, et al. Biochemistry, 2005 Feb 8. PMID 15683248

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Unique amino acids were revealed in the PfOPRTase active sites and specific protein-protein interactions.
    Title: Structure of Plasmodium falciparum orotate phosphoribosyltransferase with autologous inhibitory protein-protein interactions.
  2. Studied the multienzyme complex formation of human malaria parasite Plasmodium falciparum (P. falciparum) orotate phosphoribosyltransferase (OPRT) and orotidine 5'-monophosphate decarboxylase (OMPDC).
    Title: A unique insertion of low complexity amino acid sequence underlies protein-protein interaction in human malaria parasite orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase.
  3. OPRT transition state analogues identify crucial components of potent inhibitors targeting OPRT enzymes. Despite their tight binding to the targets, the inhibitors did not kill cultured P. falciparum
    Title: Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases.
  4. The result suggests that the OPRT-OMPDC enzyme complex might have kinetic benefits and thermal stability significantly different from the monofunctional enzyme.
    Title: Kinetic benefits and thermal stability of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase enzyme complex in human malaria parasite Plasmodium falciparum.
  5. cloning and expression analysis of dihydroorotase, orotate phosphoribosyltransferase, and OMP decarboxylase
    Title: Cloning and expression of malarial pyrimidine enzymes.
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General gene information

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Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
orotate phosphoribosyltransferase
XP_001351684.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004326.2 Reference assembly

    Range
    546734..547579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001351648.1 → XP_001351684.1  orotate phosphoribosyltransferase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001351684.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A024VAT2, A0A024VU88, A0A024WC47, A0A024XE47, A0A0L7K5S5, A0A2I0BUC2, Q8I3Y0, Q8N0R1, W4ILL1, W4IU50, W7FST1, W7G2V6, W7K2N6
    Conserved Domains (1) summary
    cl00309
    Location:79 → 275
    PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain
Nucleotide Protein
Heading Accession and Version

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