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PF3D7_0513300 purine nucleoside phosphorylase [ Plasmodium falciparum 3D7 ]

Gene ID: 812947, updated on 16-Oct-2023

Summary

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Gene symbol
PF3D7_0513300
Gene description
purine nucleoside phosphorylase
Locus tag
PF3D7_0513300
Gene type
protein coding
RNA name
purine nucleoside phosphorylase
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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Location:
chromosome: 5
Exon count:
1
Sequence:
Chromosome: 5; NC_004326.2 (569182..569919, complement)

Chromosome 5 - NC_004326.2Genomic Context describing neighboring genes Neighboring gene conserved protein, unknown function Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene GTP-binding protein, putative Neighboring gene mitochondrial import inner membrane translocase subunit TIM16, putative

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004326.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay. Dziekan JM, et al. Sci Transl Med, 2019 Jan 2. PMID 30602534
  2. Identification of a novel putative inhibitor of the Plasmodium falciparum purine nucleoside phosphorylase: exploring the purine salvage pathway to design new antimalarial drugs. Kagami LP, et al. Mol Divers, 2017 Aug. PMID 28523625
  3. Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function. Shi W, et al. J Biol Chem, 2004 Apr 30. PMID 14982926
  4. A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, et al. Nature, 2005 Nov 3. PMID 16267556
  5. Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, et al. Nature, 2002 Oct 3. PMID 12368867

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables purine-nucleoside phosphorylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within inosine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within purine nucleoside catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
purine nucleoside phosphorylase
XP_001351690.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004326.2 Reference assembly

    Range
    569182..569919 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001351654.1 → XP_001351690.1  purine nucleoside phosphorylase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001351690.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q8I3X4, Q8T9Z7
    UniProtKB/TrEMBL
    A0A024VCE7, A0A024VTV3, A0A024WUP1, A0A024XBX4, A0A0L1I561, A0A0L7K5U1, A0A0L7M7R1, W4ILI6, W4IVZ2, W7F6C4, W7GAS3, W7JSY1, W7KKX8
    Conserved Domains (1) summary
    cd17767
    Location:7 → 238
    UP_EcUdp-like; uridine phosphorylases similar to Escherichia coli Udp and related phosphorylases
Nucleotide Protein
Heading Accession and Version

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