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PF3D7_0112200 multidrug resistance-associated protein 1 [ Plasmodium falciparum 3D7 ]

Gene ID: 813255, updated on 23-Nov-2023

Summary

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Gene symbol
PF3D7_0112200
Gene description
multidrug resistance-associated protein 1
Locus tag
PF3D7_0112200
Gene type
protein coding
RNA name
multidrug resistance-associated protein 1
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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Location:
chromosome: 1
Exon count:
1
Sequence:
Chromosome: 1; NC_004325.2 (464726..470194)

Chromosome 1 - NC_004325.2Genomic Context describing neighboring genes Neighboring gene TatD-like deoxyribonuclease Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene 18S ribosomal RNA Neighboring gene ribosomal RNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004325.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Disruption of a Plasmodium falciparum multidrug resistance-associated protein (PfMRP) alters its fitness and transport of antimalarial drugs and glutathione. Raj DK, et al. J Biol Chem, 2009 Mar 20. PMID 19117944, Free PMC Article
  2. Plasmodium falciparum expresses a multidrug resistance-associated protein. Klokouzas A, et al. Biochem Biophys Res Commun, 2004 Aug 13. PMID 15358235
  3. Absence of association between piperaquine in vitro responses and polymorphisms in the pfcrt, pfmdr1, pfmrp, and pfnhe genes in Plasmodium falciparum. Briolant S, et al. Antimicrob Agents Chemother, 2010 Sep. PMID 20547801, Free PMC Article
  4. A network-based approach reveals novel invasion and Maurer's clefts-related proteins in Plasmodium falciparum. Das D, et al. Mol Omics, 2019 Dec 2. PMID 31631203
  5. Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, et al. Nature, 2002 Oct 3. PMID 12368867

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. There was an absence of cross-resistance with quinolines, and the IC(50)s for PPQ and DHA were found to be unrelated to mutations in the pfcrt, pfmdr1, pfmrp, and pfnhe-1 transport protein genes.
    Title: Absence of association between piperaquine in vitro responses and polymorphisms in the pfcrt, pfmdr1, pfmrp, and pfnhe genes in Plasmodium falciparum.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables glutathione binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Maurer's cleft RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
multidrug resistance-associated protein 1
XP_001351050.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004325.2 Reference assembly

    Range
    464726..470194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001351014.1 → XP_001351050.1  multidrug resistance-associated protein 1 [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001351050.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A024WFC3, A0A024WXC2, A0A024XEW3, A0A076PXU8, A0A076Q439, A0A0L7KE24, D0QEV0, D0QEV4, D0QEV8, D0QEW0, Q9U0N4, W4J8S2, W7FK44, W7GD98, W7JKD6, W7K2N3
    Conserved Domains (3) summary
    PLN03232
    Location:655 → 1799
    PLN03232; ABC transporter C family member; Provisional
    cl38913
    Location:304 → 501
    ABC_6TM_exporters; Six-transmembrane helical domain of the ATP-binding cassette transporters
    cl38936
    Location:655 → 912
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
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