U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PF3D7_1316600 choline-phosphate cytidylyltransferase [ Plasmodium falciparum 3D7 ]

Gene ID: 813977, updated on 16-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
PF3D7_1316600
Gene description
choline-phosphate cytidylyltransferase
Locus tag
PF3D7_1316600
Gene type
protein coding
RNA name
choline-phosphate cytidylyltransferase
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 13
Exon count:
3
Sequence:
Chromosome: 13; NC_004331.3 (691014..694125)

Chromosome 13 - NC_004331.3Genomic Context describing neighboring genes Neighboring gene SAS6-like protein, putative Neighboring gene pre-mRNA-processing factor 40, putative Neighboring gene conserved protein, unknown function Neighboring gene protein transport protein SEC20, putative

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_004331.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of a nuclear localization signal in the Plasmodium falciparum CTP: phosphocholine cytidylyltransferase enzyme. Izrael R, et al. Sci Rep, 2020 Nov 12. PMID 33184408, Free PMC Article
  2. Molecular Mechanism for the Thermo-Sensitive Phenotype of CHO-MT58 Cell Line Harbouring a Mutant CTP:Phosphocholine Cytidylyltransferase. Marton L, et al. PLoS One, 2015. PMID 26083347, Free PMC Article
  3. Plasmodium falciparum CTP:phosphocholine cytidylyltransferase possesses two functional catalytic domains and is inhibited by a CDP-choline analog selected from a virtual screening. Contet A, et al. FEBS Lett, 2015 Apr 13. PMID 25771858
  4. Evolutionary and mechanistic insights into substrate and product accommodation of CTP:phosphocholine cytidylyltransferase from Plasmodium falciparum. Nagy GN, et al. FEBS J, 2013 Jul. PMID 23578277
  5. PG12, a phospholipid analog with potent antimalarial activity, inhibits Plasmodium falciparum CTP:phosphocholine cytidylyltransferase activity. González-Bulnes P, et al. J Biol Chem, 2011 Aug 19. PMID 21705805, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mechanism for the Thermo-Sensitive Phenotype of CHO-MT58 Cell Line Harbouring a Mutant CTP:Phosphocholine Cytidylyltransferase
    Title: Molecular Mechanism for the Thermo-Sensitive Phenotype of CHO-MT58 Cell Line Harbouring a Mutant CTP:Phosphocholine Cytidylyltransferase.
  2. Data indicate CTP:phosphocholine cytidylyltransferase (PfCCT) is the rate-limiting enzyme of the phosphatidylcholine biosynthesis pathway and thus considered as a potential antimalarial target.
    Title: Plasmodium falciparum CTP:phosphocholine cytidylyltransferase possesses two functional catalytic domains and is inhibited by a CDP-choline analog selected from a virtual screening.
  3. Data suggest that catalytic mechanism of CCT may involve conformational changes at active site affecting binding of choline at subsite within the enzyme; studies include amino acid sequence alignment/homology and consideration of molecular evolution.
    Title: Evolutionary and mechanistic insights into substrate and product accommodation of CTP:phosphocholine cytidylyltransferase from Plasmodium falciparum.
  4. PG12, a phospholipid analog with potent antimalarial activity, inhibits Plasmodium falciparum
    Title: PG12, a phospholipid analog with potent antimalarial activity, inhibits Plasmodium falciparum CTP:phosphocholine cytidylyltransferase activity.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables choline-phosphate cytidylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within phosphatidylcholine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
choline-phosphate cytidylyltransferase
XP_001349902.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004331.3 Reference assembly

    Range
    691014..694125
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001349866.1 → XP_001349902.1  choline-phosphate cytidylyltransferase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001349902.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0L1I915, A0A0L7KIH7, A0A2I0BVS0, Q8IEE9
    Conserved Domains (1) summary
    cd02174
    Location:616 → 783
    CCT; CTP:phosphocholine cytidylyltransferase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous