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PF3D7_1324900 L-lactate dehydrogenase [ Plasmodium falciparum 3D7 ]

Gene ID: 814112, updated on 16-Oct-2023

Summary

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Gene symbol
PF3D7_1324900
Gene description
L-lactate dehydrogenase
Locus tag
PF3D7_1324900
Gene type
protein coding
RNA name
L-lactate dehydrogenase
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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Location:
chromosome: 13
Exon count:
1
Sequence:
Chromosome: 13; NC_004331.3 (1041157..1042107)

Chromosome 13 - NC_004331.3Genomic Context describing neighboring genes Neighboring gene SNARE protein, putative Neighboring gene dihydrofolate synthase/folylpolyglutamate synthase Neighboring gene U6 snRNA-associated Sm-like protein LSm6, putative Neighboring gene phosphoribosylpyrophosphate synthetase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004331.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparum in vitro. Correa R, et al. Sci Rep, 2019 Mar 25. PMID 30911042, Free PMC Article
  2. Structural basis for discriminatory recognition of Plasmodium lactate dehydrogenase by a DNA aptamer. Cheung YW, et al. Proc Natl Acad Sci U S A, 2013 Oct 1. PMID 24043813, Free PMC Article
  3. HRP2 and pLDH-Based Rapid Diagnostic Tests, Expert Microscopy, and PCR for Detection of Malaria Infection during Pregnancy and at Delivery in Areas of Varied Transmission: A Prospective Cohort Study in Burkina Faso and Uganda. Kyabayinze DJ, et al. PLoS One, 2016. PMID 27380525, Free PMC Article
  4. The interactome of 2-Cys peroxiredoxins in Plasmodium falciparum. Brandstaedter C, et al. Sci Rep, 2019 Sep 19. PMID 31537845, Free PMC Article
  5. A secretory multifunctional serine protease, DegP of Plasmodium falciparum, plays an important role in thermo-oxidative stress, parasite growth and development. Sharma S, et al. FEBS J, 2014 Mar. PMID 24494818

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparum in vitro.
    Title: Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparum in vitro.
  2. Data suggest that HRP2/pan pLDH rapid diagnostic tests (RDTs), with specificity greater than 96%, are the most appropriate point-of-care test currently available for use during pregnancy especially for symptomatic women.
    Title: HRP2 and pLDH-Based Rapid Diagnostic Tests, Expert Microscopy, and PCR for Detection of Malaria Infection during Pregnancy and at Delivery in Areas of Varied Transmission: A Prospective Cohort Study in Burkina Faso and Uganda.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in extracellular vesicle HDA PubMed 
located_in extracellular vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in food vacuole HDA PubMed 
located_in intracellular anatomical structure ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in mitochondrion RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
L-lactate dehydrogenase
XP_001349989.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004331.3 Reference assembly

    Range
    1041157..1042107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001349953.1 → XP_001349989.1  L-lactate dehydrogenase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001349989.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q27743
    UniProtKB/TrEMBL
    A0A024V3C8, A0A024VEG1, A0A024W2N3, A0A024WJS8, A0A024X283, A0A0L1I581, A0A0L7K810, A0A0L7LZH7, A0A2S0BC21, A0A2S0BC37, A0A2S0BC44, A0A2S0BF37, A0A2S0D660, A0A4Y5WWV5, Q71T02, Q76NM3, W4IC99, W4IX97, W7EW58, W7FQH8, W7J807, W7KAW6
    Conserved Domains (1) summary
    PTZ00082
    Location:1 → 316
    PTZ00082; L-lactate dehydrogenase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
3ZH2_A.1
3ZH2_B.1
3ZH2_C.1
3ZH2_D.1

Gene LinkOut

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