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PF3D7_1327600 nicotinamide/nicotinic acid mononucleotide adenylyltransferase [ Plasmodium falciparum 3D7 ]

Gene ID: 814129, updated on 16-Oct-2023

Summary

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Gene symbol
PF3D7_1327600
Gene description
nicotinamide/nicotinic acid mononucleotide adenylyltransferase
Locus tag
PF3D7_1327600
Gene type
protein coding
RNA name
nicotinamide/nicotinic acid mononucleotide adenylyltransferase
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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Genomic context

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Location:
chromosome: 13
Exon count:
1
Sequence:
Chromosome: 13; NC_004331.3 (1159366..1159980)

Chromosome 13 - NC_004331.3Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene conserved protein, unknown function Neighboring gene regulator of nonsense transcripts 3B, putative Neighboring gene ribose-phosphate pyrophosphokinase, putative

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004331.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Localization and phosphorylation of Plasmodium falciparum nicotinamide/nicotinate mononucleotide adenylyltransferase (PfNMNAT) in intraerythrocytic stages. Nieto CA, et al. Malar J, 2018 Apr 11. PMID 29642910, Free PMC Article
  2. Structural and Functional Characterization of Plasmodium falciparum Nicotinic Acid Mononucleotide Adenylyltransferase. Bathke J, et al. J Mol Biol, 2016 Dec 4. PMID 27984041
  3. Targeting NAD+ metabolism in the human malaria parasite Plasmodium falciparum. O'Hara JK, et al. PLoS One, 2014. PMID 24747974, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These experiments confirmed that the parasite is situated in the cytoplasm, fulfilling the required functions of NAD+ in this compartment, the PfNMNAT is regulated in post-transcription processes, and can be regulated by phosphorylation in its residues.
    Title: Localization and phosphorylation of Plasmodium falciparum nicotinamide/nicotinate mononucleotide adenylyltransferase (PfNMNAT) in intraerythrocytic stages.
  2. Furthermore, nicotinic acid mononucleotide adenylyltransferase (NaMNAT) possesses two cysteine residues within the active site that have not been described for any other NaMNATase so far and are likely to be involved in redox regulation of NaMNAT activity.
    Title: Structural and Functional Characterization of Plasmodium falciparum Nicotinic Acid Mononucleotide Adenylyltransferase.
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General gene information

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Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables nicotinamide-nucleotide adenylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nicotinate-nucleotide adenylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nicotinamide/nicotinic acid mononucleotide adenylyltransferase
XP_001350021.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004331.3 Reference assembly

    Range
    1159366..1159980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001349985.1 → XP_001350021.1  nicotinamide/nicotinic acid mononucleotide adenylyltransferase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001350021.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A024V2T4, A0A024VLZ8, A0A024W2L8, A0A024WJV7, A0A024X3D4, A0A0L7KII8, Q8IE38, W4I6D0, W4IZ16, W7EW85, W7FUD4, W7JIS4, W7JPX8
    Conserved Domains (1) summary
    cl00015
    Location:1 → 201
    nt_trans; nucleotidyl transferase superfamily
Nucleotide Protein
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