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Myoc myocilin [ Rattus norvegicus (Norway rat) ]

Gene ID: 81523, updated on 4-Jan-2025

Summary

Official Symbol
Myocprovided by RGD
Official Full Name
myocilinprovided by RGD
Primary source
RGD:620430
See related
EnsemblRapid:ENSRNOG00000003221 AllianceGenome:RGD:620430
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tigr
Summary
Predicted to enable fibronectin binding activity; myosin light chain binding activity; and signaling receptor binding activity. Involved in cellular response to nerve growth factor stimulus and nerve development. Located in Schmidt-Lanterman incisure; mesaxon; and myelin sheath abaxonal region. Biomarker of membranoproliferative glomerulonephritis and ocular hypertension. Human ortholog(s) of this gene implicated in juvenile glaucoma; low tension glaucoma; ocular hypertension; open-angle glaucoma; and primary open angle glaucoma. Orthologous to human MYOC (myocilin). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Muscle (RPKM 306.7), Heart (RPKM 55.9) and 2 other tissues See more
Orthologs
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Genomic context

See Myoc in Genome Data Viewer
Location:
13q22
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (77509963..77520361)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (74976730..74987128)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (80517531..80527928)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096299 Neighboring gene vesicle-associated membrane protein 4 Neighboring gene proline-rich coiled-coil 2C Neighboring gene uncharacterized LOC134481577 Neighboring gene uncharacterized LOC102555487 Neighboring gene flavin containing dimethylaniline monoxygenase 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables fibronectin binding  
enables fibronectin binding  
enables frizzled binding  
enables frizzled binding  
enables metal ion binding  
enables myosin light chain binding  
enables myosin light chain binding  
enables receptor tyrosine kinase binding  
enables receptor tyrosine kinase binding  
Items 1 - 25 of 59
Process Evidence Code Pubs
involved_in ERBB2-ERBB3 signaling pathway  
involved_in ERBB2-ERBB3 signaling pathway  
involved_in ERBB2-ERBB3 signaling pathway  
involved_in bone development  
involved_in bone development  
involved_in bone development  
involved_in cellular response to nerve growth factor stimulus PubMed 
involved_in clustering of voltage-gated sodium channels  
involved_in clustering of voltage-gated sodium channels  
involved_in clustering of voltage-gated sodium channels  
involved_in myelination in peripheral nervous system  
involved_in myelination in peripheral nervous system  
involved_in myelination in peripheral nervous system  
involved_in negative regulation of Rho protein signal transduction  
involved_in negative regulation of Rho protein signal transduction  
involved_in negative regulation of Rho protein signal transduction  
involved_in negative regulation of cell-matrix adhesion  
involved_in negative regulation of cell-matrix adhesion  
involved_in negative regulation of cell-matrix adhesion  
involved_in negative regulation of stress fiber assembly  
involved_in negative regulation of stress fiber assembly  
involved_in negative regulation of stress fiber assembly  
involved_in nerve development PubMed 
involved_in neuron projection development  
involved_in neuron projection development  
involved_in neuron projection development  
involved_in non-canonical Wnt signaling pathway  
involved_in non-canonical Wnt signaling pathway  
involved_in non-canonical Wnt signaling pathway  
involved_in osteoblast differentiation  
involved_in osteoblast differentiation  
involved_in osteoblast differentiation  
involved_in osteoblast differentiation  
involved_in positive regulation of JNK cascade  
involved_in positive regulation of JNK cascade  
involved_in positive regulation of cell migration  
involved_in positive regulation of cell migration  
involved_in positive regulation of cell migration  
involved_in positive regulation of focal adhesion assembly  
involved_in positive regulation of focal adhesion assembly  
involved_in positive regulation of focal adhesion assembly  
involved_in positive regulation of mitochondrial depolarization  
involved_in positive regulation of mitochondrial depolarization  
involved_in positive regulation of mitochondrial depolarization  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in positive regulation of stress fiber assembly  
involved_in positive regulation of stress fiber assembly  
involved_in positive regulation of stress fiber assembly  
involved_in positive regulation of substrate adhesion-dependent cell spreading  
involved_in positive regulation of substrate adhesion-dependent cell spreading  
involved_in positive regulation of substrate adhesion-dependent cell spreading  
involved_in regulation of MAPK cascade  
involved_in regulation of MAPK cascade  
involved_in signal transduction  
involved_in skeletal muscle hypertrophy  
involved_in skeletal muscle hypertrophy  
involved_in skeletal muscle hypertrophy  
Items 1 - 25 of 59
Items 1 - 20 of 33
Component Evidence Code Pubs
is_active_in Golgi apparatus  
located_in Golgi apparatus  
located_in Golgi apparatus  
located_in Golgi apparatus  
located_in Schmidt-Lanterman incisure PubMed 
located_in cilium  
located_in collagen-containing extracellular matrix  
located_in collagen-containing extracellular matrix  
located_in collagen-containing extracellular matrix  
located_in cytoplasmic vesicle  
located_in cytoplasmic vesicle  
located_in cytoplasmic vesicle  
located_in endoplasmic reticulum  
located_in endoplasmic reticulum  
located_in extracellular exosome  
is_active_in extracellular space  
located_in extracellular space  
located_in extracellular space  
located_in mesaxon PubMed 
located_in mitochondrial inner membrane  
located_in mitochondrial inner membrane  
located_in mitochondrial inner membrane  
located_in mitochondrial intermembrane space  
located_in mitochondrial intermembrane space  
located_in mitochondrial intermembrane space  
located_in mitochondrial outer membrane  
located_in mitochondrial outer membrane  
located_in mitochondrial outer membrane  
located_in myelin sheath abaxonal region PubMed 
located_in node of Ranvier  
located_in node of Ranvier  
located_in node of Ranvier  
located_in rough endoplasmic reticulum  
Items 1 - 20 of 33

General protein information

Preferred Names
myocilin
Names
myocilin, trabecular meshwork inducible glucocorticoid response
trabecular meshwork-induced glucocorticoid response protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030865.2NP_110492.2  myocilin precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    Q9R1J4, Q9Z2Y4
    UniProtKB/TrEMBL
    A6ID98, G3V6E8
    Related
    ENSRNOP00000004386.2, ENSRNOT00000004386.6
    Conserved Domains (2) summary
    smart00284
    Location:244501
    OLF; Olfactomedin-like domains
    NF033777
    Location:68201
    M_group_A_cterm; M protein C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    77509963..77520361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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