Crh corticotropin releasing hormone [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Crhprovided by RGD
Official Full Name: corticotropin releasing hormoneprovided by RGD
Primary source: RGD:620505
See related: Ensembl:ENSRNOG00000012703 AllianceGenome:RGD:620505
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CRF
Summary: Enables corticotropin-releasing hormone receptor 1 binding activity and corticotropin-releasing hormone receptor 2 binding activity. Involved in several processes, including regulation of ion transport; regulation of secretion by cell; and response to glucocorticoid. Located in several cellular components, including extracellular space; perikaryon; and varicosity. Used to study hypoglycemia and obesity. Biomarker of several diseases, including alcohol use disorder; cerebrovascular disease (multiple); extrahepatic cholestasis; sciatic neuropathy; and withdrawal disorder. Human ortholog(s) of this gene implicated in obesity and panic disorder. Orthologous to human CRH (corticotropin releasing hormone). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 20.2), Heart (RPKM 11.8) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 2q24

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (104059184..104061048, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (102143055..102144919, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (104459999..104461863, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Two Adverse Early Life Events Induce Differential Changes in Brain CRH and Serotonin Systems in Rats along with Hyperphagia and Depression.
Title: Two Adverse Early Life Events Induce Differential Changes in Brain CRH and Serotonin Systems in Rats along with Hyperphagia and Depression.
Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension.
Title: Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension.
Corticotropin Releasing Factor Mediates KCa3.1 Inhibition, Hyperexcitability, and Seizures in Acquired Epilepsy.
Title: Corticotropin Releasing Factor Mediates K(Ca)3.1 Inhibition, Hyperexcitability, and Seizures in Acquired Epilepsy.
Early life stress induces a transient increase in hippocampal corticotropin-releasing hormone in rat neonates that precedes the effects on hypothalamic neuropeptides.
Title: Early life stress induces a transient increase in hippocampal corticotropin-releasing hormone in rat neonates that precedes the effects on hypothalamic neuropeptides.
Stress and corticotropin releasing factor (CRF) promote necrotizing enterocolitis in a formula-fed neonatal rat model.
Title: Stress and corticotropin releasing factor (CRF) promote necrotizing enterocolitis in a formula-fed neonatal rat model.
Cytokines in the colon, central nervous system and serum of irritable bowel syndrome rats.
Title: Cytokines in the colon, central nervous system and serum of irritable bowel syndrome rats.
Overexpression of corticotropin-releasing factor in the nucleus accumbens enhances the reinforcing effects of nicotine in intact female versus male and ovariectomized female rats.
Title: Overexpression of corticotropin-releasing factor in the nucleus accumbens enhances the reinforcing effects of nicotine in intact female versus male and ovariectomized female rats.
CRF2 plays an important role in gastric hyperalgesia produced by stress; CRF2 signaling may be a useful therapeutic target for functional dyspepsia
Title: The role of peripheral corticotropin-releasing factor signaling in a rat model of stress-induced gastric hyperalgesia.
central amygdala neurons that release the stress neuropeptide corticotropin-releasing factor drive anxiety-like behaviors in rats via a pathway to dorsal bed nucleus of the stria terminalis
Title: A Corticotropin Releasing Factor Network in the Extended Amygdala for Anxiety.
mediates stress-induced visceral allodynia and increased colonic permeability
Title: Altered colonic sensory and barrier functions by CRF: roles of TLR4 and IL-1.

Submit: New GeneRIF Correction See all GeneRIFs (211)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables corticotropin-releasing hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables corticotropin-releasing hormone receptor 1 binding	IDA Inferred from Direct Assay more info	PubMed
enables corticotropin-releasing hormone receptor 1 binding	IPI Inferred from Physical Interaction more info	PubMed
enables corticotropin-releasing hormone receptor 2 binding	IDA Inferred from Direct Assay more info	PubMed
enables corticotropin-releasing hormone receptor 2 binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adrenal gland development	ISO Inferred from Sequence Orthology more info
involved_in associative learning	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to cocaine	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in diterpenoid metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in female pregnancy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucocorticoid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in hypothalamus development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory exploration behavior	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic potentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion homeostasis	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of epinephrine secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of epinephrine secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glucagon secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of glucagon secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of luteinizing hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of norepinephrine secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of systemic arterial blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of behavioral fear response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cAMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of calcium ion import	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of corticosterone secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of corticosterone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of corticotropin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of corticotropin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of corticotropin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cortisol secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cortisol secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of digestive system process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of serotonin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to alcohol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to aldosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to corticosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ether	IEP Inferred from Expression Pattern more info	PubMed
NOT involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to pain	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in steroid metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in synaptic transmission, dopaminergic	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic transmission, dopaminergic	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	TAS Traceable Author Statement more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in neuronal dense core vesicle lumen	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in varicosity	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: corticoliberin

Names: corticotropin-releasing factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.