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Pls3 plastin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81748, updated on 11-Apr-2024

Summary

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Official Symbol
Pls3provided by RGD
Official Full Name
plastin 3provided by RGD
Primary source
RGD:621409
See related
Ensembl:ENSRNOG00000027520 AllianceGenome:RGD:621409
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin filament binding activity. Predicted to be a structural constituent of presynaptic actin cytoskeleton. Involved in inner ear auditory receptor cell differentiation. Located in stereocilium. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human PLS3 (plastin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 442.8), Liver (RPKM 227.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pls3 in Genome Data Viewer
Location:
Xq34
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (116401247..116495898)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (111589193..111683908)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (119030311..119124268)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene nucleophosmin 1, pseudogene 9 Neighboring gene small nucleolar RNA SNORA40 Neighboring gene uncharacterized LOC134484073 Neighboring gene uncharacterized LOC120099378

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transient expression of the t-isoform of plastins/fimbrin in the stereocilia of developing auditory hair cells. Daudet N, et al. Cell Motil Cytoskeleton, 2002 Dec. PMID 12378542
  2. PLS3 mutations in X-linked osteoporosis with fractures. van Dijk FS, et al. N Engl J Med, 2013 Oct 17. PMID 24088043
  3. Plastin 3 ameliorates spinal muscular atrophy via delayed axon pruning and improves neuromuscular junction functionality. Ackermann B, et al. Hum Mol Genet, 2013 Apr 1. PMID 23263861
  4. Sequential expression and differential localization of I-, L-, and T-fimbrin during differentiation of the mouse intestine and yolk sac. Chafel MM, et al. Dev Dyn, 1995 Jun. PMID 7655078
  5. Review series: The cell biology of hearing. Schwander M, et al. J Cell Biol, 2010 Jul 12. PMID 20624897, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of presynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament bundle assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in actin filament network formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bone development IEA
Inferred from Electronic Annotation
more info
  
involved_in bone development ISO
Inferred from Sequence Orthology
more info
  
involved_in inner ear auditory receptor cell differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in presynaptic actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic vesicle cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in actin filament bundle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in stereocilium IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
plastin-3
Names
T-plastin
plastin 3 (T-isoform)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031084.1 → NP_112346.1  plastin-3

    See identical proteins and their annotated locations for NP_112346.1

    Status: VALIDATED

    Source sequence(s)
    BC092611, CB557206, CB798973
    UniProtKB/Swiss-Prot
    Q63598
    UniProtKB/TrEMBL
    A6KGB3
    Related
    ENSRNOP00000056912.4, ENSRNOT00000060168.3
    Conserved Domains (5) summary
    cd00051
    Location:16 → 82
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd21292
    Location:101 → 245
    CH_PLS_rpt1; first calponin homology (CH) domain found in the plastin family
    cd21328
    Location:254 → 375
    CH_PLS3_rpt2; second calponin homology (CH) domain found in plastin-3
    cd21331
    Location:377 → 510
    CH_PLS3_rpt3; third calponin homology (CH) domain found in plastin-3
    cd21334
    Location:519 → 630
    CH_PLS3_rpt4; fourth calponin homology (CH) domain found in plastin-3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    116401247..116495898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006257434.3 → XP_006257496.1  plastin-3 isoform X1

    UniProtKB/Swiss-Prot
    Q63598
    Conserved Domains (5) summary
    cd00051
    Location:16 → 82
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd21292
    Location:101 → 245
    CH_PLS_rpt1; first calponin homology (CH) domain found in the plastin family
    cd21331
    Location:386 → 519
    CH_PLS3_rpt3; third calponin homology (CH) domain found in plastin-3
    cd21334
    Location:528 → 639
    CH_PLS3_rpt4; fourth calponin homology (CH) domain found in plastin-3
    cl00030
    Location:254 → 384
    CH_SF; calponin homology (CH) domain superfamily

  2. XM_063280326.1 → XP_063136396.1  plastin-3 isoform X2

  3. XM_063280325.1 → XP_063136395.1  plastin-3 isoform X1

  4. XM_017602163.3 → XP_017457652.1  plastin-3 isoform X1

    UniProtKB/Swiss-Prot
    Q63598
    Conserved Domains (5) summary
    cd00051
    Location:16 → 82
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd21292
    Location:101 → 245
    CH_PLS_rpt1; first calponin homology (CH) domain found in the plastin family
    cd21331
    Location:386 → 519
    CH_PLS3_rpt3; third calponin homology (CH) domain found in plastin-3
    cd21334
    Location:528 → 639
    CH_PLS3_rpt4; fourth calponin homology (CH) domain found in plastin-3
    cl00030
    Location:254 → 384
    CH_SF; calponin homology (CH) domain superfamily

  5. XM_006257438.5 → XP_006257500.1  plastin-3 isoform X3

    See identical proteins and their annotated locations for XP_006257500.1

    UniProtKB/Swiss-Prot
    Q63598
    UniProtKB/TrEMBL
    A6KGB3
    Conserved Domains (5) summary
    cd00051
    Location:16 → 82
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd21292
    Location:101 → 245
    CH_PLS_rpt1; first calponin homology (CH) domain found in the plastin family
    cd21328
    Location:254 → 375
    CH_PLS3_rpt2; second calponin homology (CH) domain found in plastin-3
    cd21331
    Location:377 → 510
    CH_PLS3_rpt3; third calponin homology (CH) domain found in plastin-3
    cd21334
    Location:519 → 630
    CH_PLS3_rpt4; fourth calponin homology (CH) domain found in plastin-3

  6. XM_017602164.3 → XP_017457653.1  plastin-3 isoform X1

    UniProtKB/Swiss-Prot
    Q63598
    Conserved Domains (5) summary
    cd00051
    Location:16 → 82
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd21292
    Location:101 → 245
    CH_PLS_rpt1; first calponin homology (CH) domain found in the plastin family
    cd21331
    Location:386 → 519
    CH_PLS3_rpt3; third calponin homology (CH) domain found in plastin-3
    cd21334
    Location:528 → 639
    CH_PLS3_rpt4; fourth calponin homology (CH) domain found in plastin-3
    cl00030
    Location:254 → 384
    CH_SF; calponin homology (CH) domain superfamily

  7. XM_063280327.1 → XP_063136397.1  plastin-3 isoform X3

    UniProtKB/TrEMBL
    A6KGB3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63598.2 GenPept UniProtKB/Swiss-Prot:Q63598

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